Abstract: A composition, device, and method for treating sexual dysfunction via inhalation is provided which comprises inhaling a dose of a powder composition, the powder composition comprising apomorphine or pharmaceutically acceptable salts thereof. Preferably, the powder composition further includes a carrier material, the carrier material has an average particle size of from about 40 to about 70 microns, and at least 90 percent of said apomorphine has a particle size of 5 microns or less.

Abstract: In a solution composition for use in an aerosol inhaler which comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility m compound the use of a mixture of HFA 134a and HFA 227 allows to modulate the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler to target specific regions of the respiratory tract. Moreover the fine particle dose (FPD) of the active ingredient in the composition increases by reducing the metering chamber volume.

Abstract: The present invention relates to a medicinal aerosol solution formulation product with improved chemical stability, comprising a pressurized metered dose inhaler, comprising an aerosol canister equipped with a metering valve and containing a medicinal aerosol solution formulation containing an active ingredient subject to a degradation by means of peroxides or other leachables, a hydrofluorocarbon propellant, a co-solvent and optionally a low-volatility component, wherein optionally part or all of the internal surfaces of said inhaler consists of stainless steel, anodized aluminum or are lined with an inert organic coating, and wherein the canister has a rim with rounded edges which avoids contact of a sharp edge with the rubber materials used as valve gaskets.

Abstract: The invention relates to the use of pressurised metered dose inhalers (MDIs) having part or all of their internal surfaces consisting of stainless steel, anodised aluminium or lined with an inert organic coating; and to compositions to be delivered with said MDIs.

Abstract: An aerosol solution composition for use in an aerosol inhaler comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility component to increase the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler. The composition is stabilized by using a small amount of mineral acid and a suitable can having part or all of its internal metallic surfaces made of stainless steel, anodized aluminium or lined with an inert organic coating.

Abstract: In a solution composition for use in an aerosol inhaler which comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility compound the use of a mixture of HFA 134a and HFA 227 allows to modulate the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler to target specific regions of the respiratory tract. Moreover the fine particle dose (FPD) of the active ingredient in the composition increases by reducing the metering chamber volume.

Abstract: An aerosol solution composition for use in an aerosol inhaler comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility component to increase the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler.

Abstract: The invention discloses formulations for administration through pressurized metered dose inhalers containing as active ingredient a glucocorticoid, in particular the (22R) epimer of budesonide, in solution in a hydrofluorocarbon propellant, a cosolvent and a suitable additive, and their use in the treatment of asthma and other bronchopulmonary disorders.

Abstract: A powder for use in a dry powder inhaler comprises an active material and an indicator material that is capable of indicating to a patient that a dose of the active material has been administered. The powder for use in an inhaler device and/or an inhaler device containing the powder may be such that a fine particle fraction of at least 35% is generated.

Abstract: The present invention relates to pressurized metered dose inhaler (pMDI) actuators having with laser-drilled orifices of novel dimensions, and to medicinal aerosol solution formulation products comprising these actuators. In particular, the present invention relates to the optimisation of the output characteristics of drug solution formulations in hydrofluoroalkanes (HFAs) by use of pMDIs with actuators with laser-drilled orifices of specific dimensions. Moreover, the actuators of the present invention allow the use of solution formulations with a high ethanol content and a high ratio of ethanol to active ingredients and thus, the use of poorly soluble active ingredients in solution formulations and allow the use of solution formulations which are substantially free of low volatility components.

Abstract: Formulations for the administration through pressurized metered dose aerosol inhalers containing an anticholineric drug in solution in a hydrofluorocarbon propellant, a cosolvent and a low volatility component, and the use thereof in chronic obstructive pulmonary disease.

Abstract: The invention provides a vacuum cleaner (10) comprising a main body (12) and a cleaner head (22) movably mounted theon, the cleaner head (22) having a downwardly directed suction opening (24), characterised in that the cleaner head (22) is mounted on the main body (12) by means of at least one articulating member (120), the or each articulating member (120) having a first end which is pivotably connected to the cleaner head (22) and a second end which is pivotably connected to the main body (12).

Abstract: The invention relates to the use of pressurised metered dose inhalers (MDIs) having part or all of their internal surfaces consisting of stainless steel, anodised aluminium or lined with an inert organic coating; and to compositions to be delivered with said MDIs.

Abstract: The invention relates to the use of pressurized metered dose inhalers (MDIs) having part or all of their internal surfaces consisting of stainless steel, anodized aluminum or lined with an inert organic coating; and to compositions to be delivered with said MDIs.

Abstract: A cuff (10) for joining together an inner and outer pipe (16, 14), the cuff being slideable along at least part of the inner pipe to allow nesting of the pipes. The cuff (10) comprises a housing (12) and an interlocking member (28). The interlocking member (28) lies, in use, in a plane extending transversely to the longitudinal axis of the pipes. The interlocking member has an actuator and an interengaging portion for interengaging with the inner pipe (16). In use, the interengaging portion lies on the side of inner pipe (16) remote from the actuator portion (30) so that, when the interlocking member (28) is translated within the plane on actuation, the interengaging portion is released from the inner pipe. A pair of diametrically opposed lugs (not shown) are located on the interlocking member (28) and a compression spring (not shown) acts between each lug and the housing (12) so as to bias the interengaging portion into engagement with the inner pipe.

Abstract: An aerosol solution composition for use in an aerosol inhaler comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility component to increase the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler. The composition is stabilized by using a small amount of mineral acid and a suitable can having part or all of its internal metallic surfaces made of stainless steel, anodized aluminium or lined with an inert organic coating.

Abstract: The invention provides an apparatus for carrying a fluid flow having at least one fluid inlet, at least one fluid outlet, a plurality of alternative fluid flow paths therebetween and valve for selecting one of the said fluid flow paths to carry a fluid flow from the or a fluid inlet to the or a fluid outlet, wherein the said valve (14) and at least part of the said alternative fluid flow paths (26, 70) are housed within a removable portion (10) of the apparatus to facilitate maintenance. Preferably, seals (32) are provided between the removable portion (10) and the remainder of the apparatus, the seals (32) being either carried by the removable portion (10) or exposed for access by removal of the removable portion (10). This arrangement facilitates removal of blockages and replacement of seals.

Abstract: A dry powder inhaler is provided which comprises a reservoir of medicament powder, a dispensing chamber for receiving a charge of powder to be dispensed having a floor upon which the powder charge lies prior to inhalation, an inlet passage having at its outlet end a nozzle protruding into the dispensing chamber directed toward the floor thereof and an inhalation passage exiting from the chamber through which the powder may be inhaled entrained in air drawn into the inhaler through the air inlet passage. The inhalation passage has an inlet at the dispensing chamber and an outlet through which the powder may be inhaled and comprises a first upstream portion having a roof and a floor both of which rise progressively with respect to a straight line drawn form the center of the inlet to the center of the outlet ad a second portion having a roof and a floor both of which fall progressively with respect to the line in the downstream direction.