Abstract: A bipod for supporting a firearm above a surface is provided, comprising a pair of opposed bipod legs which are pivotally mounted for rotation about respective inclined intersecting axes. The bipod comprises a spigot for connecting the bipod to the firearm, or to an fitting mounted on the firearm, the spigot being mounted on, or integral with, a pivotable element which is arranged to pivot about an axis extending within a triangular area defined by the inclined intersecting axes about which the bipod legs pivot and a plane defined by corresponding upper surfaces of the opposed legs when depending from the bipod in a nominal upright condition.

Abstract: The disclosure relates to the field of supporting devices and objects with tripods. In particular though not exclusively the invention relates to a tripod assembly comprising a tripod chassis body which is supportable above a surface by a plurality of tripod legs which are arranged, in use, below the chassis body, the chassis body defining a central aperture between the tripod legs, a functional module which fits in the central aperture, and locking means for locking the functional module, which has been located in the central aperture. In this way a number of functional modules can be used with a tripod to support a variety of objects such as firearms, photographic devices, or payloads. The disclosure also relates to a tripod central column according to the preceding claim including means for containing a plurality of tool components.

Abstract: The invention relates to the field of firearms and in particular but not exclusively to supporting firearms, such as rifles. A support device for supporting a firearm above a surface, the support comprising a support body for connection to the firearm and including, or for connection to, at least one support leg, the support body comprising a curved element which engages a correspondingly-shaped fixture mounted on, or integral with the firearm, the inter-engagement of the curved element and fixture permitting panning of the connected firearm, and a detent means which retains the curved element and the correspondingly-shaped fixture in engagement.

Abstract: This invention relates to the field of firearms, and in particular, though not exclusively to a support for a firearm. One aspect provides a support for a firearm for supporting the firearm above a surface, the support comprising a support body and at least two surface-engaging support legs, the support further comprising a projection which is received within a recess defined by a connection element attached to or integral with the firearm to longitudinally restrain the firearm with respect to the support, in which the support further comprises a ball detent mechanism, the ball detent mechanism including at least one ball which is biased to engage a further recess defined by the connection element attached to or integral with the firearm, the ball detent mechanism being operated by a release mechanism to withdraw the said at least one ball from the further recess, and in which the release mechanism comprises a user grippable element which extends below the projection.

Abstract: A rest system for supporting an object in relation to a surface, wherein the system comprises a rest which comprises a head unit to which the object is in use attached, the head unit comprising a support body, an object coupling to which the object is in use attached and at least one leg coupling to which a respective at least one leg is removably attached, and at least one trekking pole which provides the at least one leg.

Abstract: A method of preparing an antibody suitable for use in an equine is provided. Also provided are equinised antibodies which specifically bind to equine neuronal growth factor (NGF) and neutralise the ability of equine NGF to bind to the p75 or TrkA equine NGF receptor. The invention extends to nucleic acids encoding same and to methods of treating pain and arthritis in an equine using said antibodies and/or nucleic acids.

Abstract: A method of preparing an antibody suitable for use in a canine is provided. Also provided are caninised antibodies which specifically bind to canine neuronal growth factor (NGF) and neutralise the ability of canine NGF to bind to the p75 or TrkA canine NGF receptor. The invention extends to nucleic acids encoding same and to methods of treating pain and arthritis in a canine using said antibodies and/or nucleic acids.

Abstract: A method of preparing an antibody suitable for use in a canine is provided. Also provided are caninized antibodies which specifically bind to canine neuronal growth factor (NGF) and neutralize the ability of canine NGF to bind to the p75 or TrkA canine NGF receptor. The invention extends to nucleic acids encoding same and to methods of treating pain and arthritis in a canine using said antibodies and/or nucleic acids.

Abstract: Provided herein is an isolated tumour necrosis factor receptor (TNFR) polypeptide capable of binding to TNF, or a TNF-binding fragment thereof, wherein the polypeptide comprises an amino acid sequence of SEQ ID NO:1, or an amino acid sequence that has at least 60% identity thereto and wherein the polypeptide or TNF-binding fragment comprises an N-terminal VPAQV motif (SEQ ID NO: 68), with the proviso that the polypeptide is not mouse TNFR p80 isoform. Also provided is a fusion protein comprising said polypeptide, or a TNF-binding fragment thereof, linked to a fusion partner, such as the CH2 and CH3 domains of an immunoglobulin heavy chain constant region. The polypeptides and fusion proteins disclosed herein may be used for diagnostic purposes and in the treatment or prevention of conditions mediated by TNF, particularly in non-human animals such as feline and equine.

Abstract: A rest system for supporting an object in relation to a surface, wherein the system comprises a rest which comprises a head unit to which the object is in use attached, the head unit comprising a support body, an object coupling to which the object is in use attached and at least one leg coupling to which a respective at least one leg is removably attached, and at least one trekking pole which provides the at least one leg.

Abstract: A chimeric fusion polypeptide is provided comprising an extracellular domain of a canine TNF receptor p60 or p80 polypeptide conjoined to an Fc region of a canine IgG immunoglobulin heavy chain. The chimeric fusion polypeptide may be used in the treatment or prevention of conditions in canines mediated by TNF expression.

Abstract: A method of preparing a canine antibody suitable for use in the therapeutic treatment of a canine is provided. In particular, there is provided immunoglobulins which can be selected for the characteristic of whether they mediate downstream complement mediated immune activation when bound to a target antigen. Canine derived antibodies comprising specific heavy chain isotypes are provided. The invention extends to the use of the immunoglobulins of the invention in methods of treating conditions such as pain, inflammatory conditions and cancerous conditions in a canine.

Abstract: A chimeric fusion polypeptide is provided comprising an extracellular domain of a canine TNF receptor p60 or p80 polypeptide conjoined to an Fc region of a canine IgG immunoglobulin heavy chain. The chimeric fusion polypeptide may be used in the treatment or prevention of conditions in canines mediated by TNF expression.

Abstract: A method of preparing a canine antibody suitable for use in the therapeutic treatment of a canine is provided. In particular, there is provided immunoglobulins which can be selected for the characteristic of whether they mediate downstream complement mediated immune activation when bound to a target antigen. Canine derived antibodies comprising specific heavy chain isotypes are provided. The invention extends to the use of the immunoglobulins of the invention in methods of treating conditions such as pain, inflammatory conditions and cancerous conditions in a canine.

Abstract: A method of preparing an antibody suitable for use in a feline is provided. Also provided are chimeric and felinised antibodies which specifically bind to feline neuronal growth factor (NGF) and neutralise the ability of feline NGF to bind to the p75 or TrkA feline NGF receptor. The invention extends to nucleic acids encoding same and to methods of treating pain and arthritis in a feline using said antibodies and/or nucleic acids.

Abstract: A method of preparing an antibody suitable for use in a feline is provided. Also provided are chimeric and felinized antibodies which specifically bind to feline neuronal growth factor (NGF) and neutralize the ability of feline NGF to bind to the p75 or TrkA feline NGF receptor. The invention extends to nucleic acids encoding same and to methods of treating pain and arthritis in a feline using said antibodies and/or nucleic acids.

Abstract: A method of preparing a canine antibody suitable for use in the therapeutic treatment of a canine is provided. In particular, there is provided immunoglobulins which can be selected for the characteristic of whether they mediate downstream complement mediated immune activation when bound to a target antigen. Canine derived antibodies comprising specific heavy chain isotypes are provided. The invention extends to the use of the immunoglobulins of the invention in methods of treating conditions such as pain, inflammatory conditions and cancerous conditions in a canine.

Abstract: A chimeric fusion polypeptide is provided comprising an extracellular domain of a canine TNF receptor p60 or p80 polypeptide conjoined to an Fc region of a canine IgG immunoglobulin heavy chain. The chimeric fusion polypeptide may be used in the treatment or prevention of conditions in canines mediated by TNF expression.