Abstract: A bi-directional clutch assembly equipped with a pair of laterally-spaced, selectable one-way clutches configured in a compact arrangement. The bi-directional clutch assembly establishes a LOCK-LOCK mode when both SOWC's are non-actuated, establishes a FREEWHEEL mode when both SOWC's are actuated, and establishes a pair of LOCK-RATCHET mode when one SOWC is actuated and the other is not actuated. Coils units of the SOWC's are energized to shift an actuator toward active struts of an outer race. The actuator is rotationally fixed to the outer race. The active struts are biased toward the deployed position, and the actuator is biased toward the non-actuated position. The actuator includes a strut engagement feature that contacts the active struts and causes pivotal movement of the active struts to the non-deployed position.

Abstract: A bi-directional clutch assembly equipped with a pair of laterally-spaced, selectable one-way clutches configured in a compact arrangement. The bi-directional clutch assembly establishes a LOCK-LOCK mode when both SOWC's are non-actuated, establishes a FREEWHEEL mode when both SOWC's are actuated, and establishes a pair of LOCK-RATCHET mode when one SOWC is actuated and the other is not actuated. Coils units of the SOWC's are energized to shift an actuator toward active struts of an outer race. The actuator is rotationally fixed to the outer race. The active struts are biased toward the deployed position, and the actuator is biased toward the non-actuated position. The actuator includes a strut engagement feature that contacts the active struts and causes pivotal movement of the active struts to the non-deployed position.

Abstract: A controllable one-way clutch assembly having an electromagnetic actuator module equipped with an energizeable coil assembly, a strut moveable in response to energization of the coil assembly from a released position to a locked position, and a latching mechanism operable to releaseably hold the strut in the released position when the coil assembly is not energized.

Abstract: A controllable one-way clutch assembly having an electromagnetic actuator module equipped with an energizeable coil assembly, a strut moveable in response to energization of the coil assembly from a released position to a locked position, and a latching mechanism operable to releaseably hold the strut in the released position when the coil assembly is not energized.

Abstract: The present invention is directed to an improved analysis procedure for the comparative sequencing of nucleic acids using multistage mass spectrometry. More precisely, the invention is directed to a method enabling the de-novo sequencing of nucleic acid molecules using multistage mass spectrometry.

Abstract: The present invention provides reaction mixtures that include blocked oligonucleotides comprising 2?-terminator nucleotides. The blocked oligonucleotides are rendered extendible when the 2?-terminator nucleotides are removed from the oligonucleotides, e.g., via pyrophosphorolysis. The reaction mixtures can be used in various nucleic acid polymerization and/or amplification assays, among many other applications. In addition to reaction mixtures, the invention also provides related methods and reaction mixtures.

Abstract: A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5? to 3? nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification, assay.

Abstract: A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5? to 3? nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification assay.

Abstract: A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5? to 3? nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification, assay.

Abstract: A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5? to 3? nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification assay.

Abstract: The invention provides compositions the comprise nucleotides and/or nucleosides having blocking groups at 2?-positions of sugar moieties. Methods of synthesizing these nucleic acids are also provided.

Abstract: The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2?-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention also provides computers and computer readable media.