Abstract: Rotary machines are disclosed that include, in one embodiment, a rotatable shaft defining a central axis A, the shaft having a first end and a second end. The shaft can have a first hub that defines a first gearbox disposed thereon with a plurality pivots. At least one contour also having pivots is connected to the first gearbox pivots by two linkages exterior to the first gearbox. The contour has a convex outer surface that cooperates with an inwardly facing curved surface of a housing to form a working volume. A gearbox mechanism including gears, crankshafts, bearings and connecting rods creates an oscillatory motion 2 times per revolution in the linkages such that the contour is forced to navigate about the arcuate cavity without contacting the cavity at a high rate of rotating speed.

Abstract: The disclosure provides rotary machines that include, in one embodiment, a rotatable shaft defining a central axis A, the shaft having a first end and a second end. The shaft can have a first hub that defines a first gearbox disposed thereon with a plurality pivots. At least one contour also having pivots is connected to the first gearbox pivots by two linkages exterior to the first gearbox. The contour has a convex outer surface that cooperates with an inwardly facing curved surface of a housing to form a working volume. A gearbox mechanism including gears, crankshafts, bearings and connecting rods creates an oscillatory motion 2 times per revolution in the linkages such that the contour is forced to navigate about the arcuate cavity without contacting the cavity at a high rate of rotating speed.

Abstract: The disclosure provides rotary machines that include, in one embodiment, a rotatable shaft defining a central axis A, the shaft having a first end and a second end. The shaft can have a first hub that defines a first gearbox disposed thereon with a plurality pivots. At least one contour also having pivots is connected to the first gearbox pivots by two linkages exterior to the first gearbox. The contour has a convex outer surface that cooperates with an inwardly facing curved surface of a housing to form a working volume. A gearbox mechanism including gears, crankshafts, bearings and connecting rods creates an oscillatory motion 2 times per revolution in the linkages such that the contour is forced to navigate about the arcuate cavity without contacting the cavity at a high rate of rotating speed.

Abstract: The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are benzazepine compounds. These compounds are serotonin receptor (5-HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).

Abstract: The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are benzazepine compounds. These compounds are serotonin receptor (5-HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).

Abstract: The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.