Abstract: Rotary machines are disclosed that include, in one embodiment, a rotatable shaft defining a central axis A, the shaft having a first end and a second end. The shaft can have a first hub that defines a first gearbox disposed thereon with a plurality pivots. At least one contour also having pivots is connected to the first gearbox pivots by two linkages exterior to the first gearbox. The contour has a convex outer surface that cooperates with an inwardly facing curved surface of a housing to form a working volume. A gearbox mechanism including gears, crankshafts, bearings and connecting rods creates an oscillatory motion 2 times per revolution in the linkages such that the contour is forced to navigate about the arcuate cavity without contacting the cavity at a high rate of rotating speed.

Abstract: The disclosure provides rotary machines that include, in one embodiment, a rotatable shaft defining a central axis A, the shaft having a first end and a second end. The shaft can have a first hub that defines a first gearbox disposed thereon with a plurality pivots. At least one contour also having pivots is connected to the first gearbox pivots by two linkages exterior to the first gearbox. The contour has a convex outer surface that cooperates with an inwardly facing curved surface of a housing to form a working volume. A gearbox mechanism including gears, crankshafts, bearings and connecting rods creates an oscillatory motion 2 times per revolution in the linkages such that the contour is forced to navigate about the arcuate cavity without contacting the cavity at a high rate of rotating speed.

Abstract: The disclosure provides rotary machines that include, in one embodiment, a rotatable shaft defining a central axis A, the shaft having a first end and a second end. The shaft can have a first hub that defines a first gearbox disposed thereon with a plurality pivots. At least one contour also having pivots is connected to the first gearbox pivots by two linkages exterior to the first gearbox. The contour has a convex outer surface that cooperates with an inwardly facing curved surface of a housing to form a working volume. A gearbox mechanism including gears, crankshafts, bearings and connecting rods creates an oscillatory motion 2 times per revolution in the linkages such that the contour is forced to navigate about the arcuate cavity without contacting the cavity at a high rate of rotating speed.

Abstract: The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are benzazepine compounds. These compounds are serotonin receptor (5-HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).

Abstract: The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are benzazepine compounds. These compounds are serotonin receptor (5-HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).

Abstract: The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated autoimmune disease, ischemia, and other complications associated with these diseases and disorders.

Abstract: The invention relates to compounds, pharmaceutical compositions, and uses thereof, including therapeutic uses thereof, such as methods useful for treating cancer.

Abstract: The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.

Abstract: The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.

Abstract: In accordance with the present invention, a catalyst is described which comprises at least one metal selected from the group consisting of copper, zinc, iron, tungsten, molybdenum, and chromium distributed over a catalyst support comprising a material containing at least one of silicon, titanium, zirconium, magnesium, aluminum, and activated carbon. The catalyst is used to remove phosgene from a contaminated gas stream and/or reduce or eliminate phosgene from an effluent of a previously treated gas stream. At least one metal in the catalyst of the present invention is preferably present in an amount from about 0.001 wt % to about 15 wt %. When more than one metal is present, the combined metals preferably do not exceed 20 wt %. Catalysts in accordance with the present invention may be used as photocatalysts. Processes for using the catalysts and photocatalysts of the present invention are also described.

Abstract: In accordance with the present invention, a catalyst is described which comprises at least one metal selected from the group consisting of copper, zinc, iron, tungsten, molybdenum, and chromium distributed over a catalyst support comprising a material containing at least one of silicon, titanium, zirconium, magnesium, aluminum, and activated carbon. The catalyst is used to remove phosgene from a contaminated gas stream and/or reduce or eliminate phosgene from an effluent of a previously treated gas stream. At least one metal in the catalyst of the present invention is preferably present in an amount from about 0.001 wt % to about 15 wt %. When more than one metal is present, the combined metals preferably do not exceed 20 wt %. Catalysts in accordance with the present invention may be used as Photocatalysts. Processes for using the catalysts and Photocatalysts of the present invention are also described.

Abstract: In accordance with the present invention, a catalyst is described which comprises at least one metal selected from the group consisting of copper, zinc, iron, tungsten, molybdenum, and chromium distributed over a catalyst support comprising a material containing at least one of silicon, titanium, zirconium, magnesium, aluminum, and activated carbon. The catalyst is used to remove phosgene from a contaminated gas stream and/or reduce or eliminate phosgene from an effluent of a previously treated gas stream. At least one metal in the catalyst of the present invention is preferably present in an amount from about 0.001 wt % to about 15 wt %. When more than one metal is present, the combined metals preferably do not exceed 20 wt %. Catalysts in accordance with the present invention may be used as photocatalysts. Processes for using the catalysts and photocatalysts of the present invention are also described.

Abstract: A process and apparatus for the oxidation of gaseous contaminants for the control of air pollution, comprises a two stage process comprising a photolytic stage followed by a photocatalytic stage.