Patents by Inventor David GLADE

David GLADE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11986299
    Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: May 21, 2024
    Assignee: Talis Biomedical Corporation
    Inventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon, David Glade, Hédia Maamar, Michael John McAdams, Dzam-Si Jesse Ng, David Alexander Rolfe
  • Publication number: 20230070234
    Abstract: Systems and methods for detection of a signal from droplets of an emulsion. An exemplary system may comprise a fluid transporter having a tube with an open end for aspirating droplets, a singulator to arrange the droplets in single file and to space the single-file droplets from one another, and a detection channel in optical communication with a detector configured to detect a signal from droplets. In some embodiments, the singulator may have a channel junction at which a stream of droplets in single file is combined with a stream of spacing fluid, and a tapered spacing channel extending downstream from the channel junction toward the detection channel. In some embodiments, the fluid transporter may suck droplet-containing fluid and spacing fluid through the detection channel from respective sources. In some embodiments, droplets may be subjected to a disaggregation routine before they are passed through the detection channel.
    Type: Application
    Filed: November 14, 2022
    Publication date: March 9, 2023
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: David P. STUMBO, George CARMAN, Steve HOBBS, Anthony J. MAKAREWICZ, JR., Dmitri SIMONIAN, David GLADE, Joshua OEN, Denis PRISTINSKI, John DZENITIS
  • Patent number: 11499183
    Abstract: Systems and methods for detection of a signal from droplets of an emulsion. An exemplary system may comprise a fluid transporter having a tube with an open end for aspirating droplets, a singulator to arrange the droplets in single file and to space the single-file droplets from one another, and a detection channel in optical communication with a detector configured to detect a signal from droplets. In some embodiments, the singulator may have a channel junction at which a stream of droplets in single file is combined with a stream of spacing fluid, and a tapered spacing channel extending downstream from the channel junction toward the detection channel. In some embodiments, the fluid transporter may suck droplet-containing fluid and spacing fluid through the detection channel from respective sources. In some embodiments, droplets may be subjected to a disaggregation routine before they are passed through the detection channel.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: November 15, 2022
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: David P. Stumbo, George Carman, Steve Hobbs, Anthony J. Makarewicz, Jr., Dmitri Simonian, David Glade, Joshua Oen, Denis Pristinski, John Dzenitis
  • Publication number: 20220280081
    Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.
    Type: Application
    Filed: August 17, 2020
    Publication date: September 8, 2022
    Inventors: Sayeed ANDESHMAND, Thomas H. CAULEY, III, John DIXON, David GLADE, Hédia MAAMAR, Michael John McADAMS, Dzam-Si Jesse NG, David Alexander ROLFE
  • Publication number: 20210369160
    Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.
    Type: Application
    Filed: April 14, 2021
    Publication date: December 2, 2021
    Inventors: Sayeed ANDESHMAND, Thomas H. CAULEY, III, John DIXON, David GLADE, Hédia MAAMAR, Michael John McADAMS, Dzam-Si Jesse NG, David Alexander ROLFE
  • Publication number: 20210251540
    Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.
    Type: Application
    Filed: November 2, 2020
    Publication date: August 19, 2021
    Inventors: Sayeed ANDESHMAND, Thomas H. CAULEY, III, John DIXON, David GLADE, Hédia MAAMAR, Michael John McADAMS, Dzam-Si Jesse NG, David Alexander ROLFE
  • Patent number: 11008627
    Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: May 18, 2021
    Assignee: Talis Biomedical Corporation
    Inventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon, David Glade, Hédia Maamar, Michael John McAdams, Dzam-Si Jesse Ng, David Alexander Rolfe
  • Publication number: 20210047678
    Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.
    Type: Application
    Filed: October 16, 2019
    Publication date: February 18, 2021
    Inventors: Sayeed ANDESHMAND, Thomas H. CAULEY, III, John DIXON, David GLADE, Hédia MAAMAR, Michael John McADAMS, Dzam-Si Jesse NG, David Alexander ROLFE
  • Patent number: 10820847
    Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: November 3, 2020
    Assignee: Talis Biomedical Corporation
    Inventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon, David Glade, Hédia Maamar, Michael John McAdams, Dzam-Si Jesse Ng, David Alexander Rolfe
  • Publication number: 20190002956
    Abstract: Systems and methods for detection of a signal from droplets of an emulsion. An exemplary system may comprise a fluid transporter having a tube with an open end for aspirating droplets, a singulator to arrange the droplets in single file and to space the single-file droplets from one another, and a detection channel in optical communication with a detector configured to detect a signal from droplets. In some embodiments, the singulator may have a channel junction at which a stream of droplets in single file is combined with a stream of spacing fluid, and a tapered spacing channel extending downstream from the channel junction toward the detection channel. In some embodiments, the fluid transporter may suck droplet-containing fluid and spacing fluid through the detection channel from respective sources. In some embodiments, droplets may be subjected to a disaggregation routine before they are passed through the detection channel.
    Type: Application
    Filed: June 28, 2018
    Publication date: January 3, 2019
    Inventors: David P. STUMBO, George CARMAN, Steve HOBBS, Anthony J. MAKAREWICZ, JR., Dmitri SIMONIAN, David GLADE, Joshua OEN, Denis PRISTINSKI, John DZENITIS