Abstract: The present disclosure describes a dosing regimen of an IL-10F129S expression construct for treating an inflammatory joint disease (e.g., osteoarthritis) in a subject. Methods are provided for treating an inflammatory joint disease in a subject by injecting a first dose and second dose of a composition comprising an IL-10F129S expression construct into an inflamed joint of the subject according to a dosing regimen wherein the two doses of the expression construct are administered to a subject approximately 150-360 days apart. The present disclosure also provides kits comprising a first and second dose of an IL-10F129S expression construct. The kits may be useful for treating an inflammatory joint disease in a subject.

Abstract: A user-assembled free weight includes a container made of a contiguous material and having at least one cavity. A heavy curable fill material is placed inside the at least one cavity. Together the heavy curable fill material and the container produce at least a target weight and the heavy curable fill material is non-removable from the container.

Abstract: A valve operator assembly may include a housing, a yoke, and one or more stoppers. The housing is mountable on a valve, and includes a body having a sidewall including a shaft bore, to receive a shaft rotatable within the housing, and a cover having a top member mountable on a top portion of the body and a side portion extending downwards adjacent to and partially overlapping the sidewall. The yoke is operably coupled by a yoke nut to the shaft to impart rotation to a valve stem of the valve when the shaft is rotated. The one or more stoppers are disposed within the housing to restrict the linear motion of the yoke nut.

Abstract: A user-assembled free weight includes a container made of a contiguous material and having at least one cavity. A heavy curable fill material is placed inside the at least one cavity. Together the heavy curable fill material and the container produce at least a target weight and the heavy curable fill material is non-removable from the container.

Abstract: A valve operator assembly may include a housing, a yoke, and one or more stoppers. The housing is mountable on a valve, and includes a body having a sidewall including a shaft bore, to receive a shaft rotatable within the housing, and a cover having a top member mountable on a top portion of the body and a side portion extending downwards adjacent to and partially overlapping the sidewall. The yoke is operably coupled by a yoke nut to the shaft to impart rotation to a valve stem of the valve when the shaft is rotated. The one or more stoppers are disposed within the housing to restrict the linear motion of the yoke nut.

Abstract: A luminaire system is provided that has directional light projection optics combined with a light distribution modifier to produce a non-uniform angular light intensity distribution from a single or array of light sources. The luminaire system provides for light intensity distribution with directional asymmetry meeting the specifications and requirements of aviation obstruction lights. The light distribution modifier component or subassembly redirects, scatters, refracts, diffracts and/or blocks part of the projection light in the distribution of the primary optics that would otherwise produce ground scatter. Unlike peripheral light shields at the marginal limits of the light distribution from the luminaire light system, the light distribution modifier is located near to the optical axis of the projection optics system.

Abstract: A luminaire system is provided that has directional light projection optics combined with a light distribution modifier to produce a non-uniform angular light intensity distribution from a single or array of light sources. The luminaire system provides for light intensity distribution with directional asymmetry meeting the specifications and requirements of aviation obstruction lights. The light distribution modifier component or subassembly redirects, scatters, refracts, diffracts and/or blocks part of the projection light in the distribution of the primary optics that would otherwise produce ground scatter. Unlike peripheral light shields at the marginal limits of the light distribution from the luminaire light system, the light distribution modifier is located near to the optical axis of the projection optics system.

Abstract: A luminaire system is provided that has directional light projection optics combined with a light distribution modifier to produce a non-uniform angular light intensity distribution from a single or array of light sources. The luminaire system provides for light intensity distribution with directional asymmetry meeting the specifications and requirements of aviation obstruction lights. The light distribution modifier component or subassembly redirects, scatters, refracts, diffracts and/or blocks part of the projection light in the distribution of the primary optics that would otherwise produce ground scatter. Unlike peripheral light shields at the marginal limits of the light distribution from the luminaire light system, the light distribution modifier is located near to the optical axis of the projection optics system.

Abstract: A luminaire system is provided that has directional light projection optics combined with a light distribution modifier to produce a non-uniform angular light intensity distribution from a single or array of light sources. The luminaire system provides for light intensity distribution with directional asymmetry meeting the specifications and requirements of aviation obstruction lights. The light distribution modifier component or subassembly redirects, scatters, refracts, diffracts and/or blocks part of the projection light in the distribution of the primary optics that would otherwise produce ground scatter. Unlike peripheral light shields at the marginal limits of the light distribution from the luminaire light system, the light distribution modifier is located near to the optical axis of the projection optics system.

Abstract: A light projector system, including a light projector device having a light source for producing a light beam, a light mask, an objective focal lens disposed within the path of the light beam, and a gate area. The light projector system also includes a diffusion element disposed within or forward of the gate area along the path of the light beam of the projector device. The diffusion element eliminates visible chromatic aberration from an illumination zone produced by the light projector system.

Abstract: A storage tray system which includes a rack and a plurality of storage trays. The rack includes a plurality of tray runners for supporting the trays in the rack, and which allow sliding movement of the storage trays between open and closed positions. The storage trays can be inclined downwards when in the open position to allow access to their contents.

Abstract: The adjustable design is defined by examining the current residential & commercial market. To provide beamspread* flexibility of a 12V, 24V, 120V, 240V and 277V AC 50-60 HZ and 12V & 24V DC recessed or surface mounted fixture per drawing FALF dated 13-MAY-2009 (attached to provisional application) which may include all or in part the following: A. Housing B. Light source C. Optical system of some or all glass or plastic lenses, all diffusers, all refractors and shaping diffusers (holographic or otherwise) D. All mechanical adjustment systems E. All plastic or aluminum reflector/refractor Beamspread is defined as the angle of light emitting from the end of the fixture. Previously a lighting fixture installation would require the use of three or four distinct fixtures, whether round, square, asymmetric or rectangular . . . one fixture each for a narrow, medium and flood beamspread.

Abstract: A storage tray system includes a rack (2) and a plurality of storage trays (4) that are constructed and arranged to be placed in or removed from the rack. The rack (2) includes a plurality of tray runners (30) for supporting the trays (4) in the rack, the tray runners being constructed and arranged to allow sliding movement of the storage trays between open and closed positions. At least one of the tray runners (30) includes a stop element (42) that is constructed and arranged to engage a respective storage tray (4) when in the open position so as to limit movement of the tray.

Abstract: A screen using RNAi methods was used to test the entire set of protein kinases in Drosophila for an effect on mitosis. Most kinases previously known to be involved in the cell cycle were identified, providing validation of the approach. A mitotic function was found for a number of kinases not previously known to be involved in the cell cycle. Materials and methods are therefore provided for control of the cell cycle using modulators of expression or activity of kinases not previously known to act in mitosis, including human orthologues thereof.

Abstract: Polynucleotides encoding a number of Drosophila gene products are provided. Polynucleotide probes derived from these nucleotide sequences, polypeptides encoded by the polynucleotides and antibodies that bind to the polypeptides are also provided.

Abstract: A magnet keeper-shield assembly adapted to hold and store a permanent magnet used to generate a high gradient magnetic field that, in one embodiment, may penetrate into deep targeted tumor sites in order to attract magnetically responsive micro-carriers. The magnet keeper-shield assembly includes a magnetically permeable keeper-shield with a bore dimensioned to hold the magnet. A lever mechanism is used to push the magnet partially out of the keeper-shield. The actuator is assisted by several springs extending through the base of the keeper-shield.

Abstract: A system for returning a mailpiece to a sender without a human readable return address on the mailpiece. The system includes a device adapted to generate a machine-readable code to be printed on the mailpiece. The machine-readable code includes a return address for the sender. A scanning device is used to interpret the machine-readable code when it is determined that the mailpiece is to be returned to the sender. A printing device can receive instructions from the scanning device to print the return address in a human readable form for return of the mailpiece to the sender.

Abstract: Polynucleotides encoding a number of Drosophila gene products are provided. Polynucleotide probes derived from these nucleotide sequences, polypeptides encoded by the polynucleotides and antibodies that bind to the polypeptides are also provided.

Abstract: The invention describes human genes involved in cell cycle progression, including mitosis and meiosis. The invention also relates to the use of these “cell cycle progression” genes and proteins in the modulation of cell cycle progression in cells and methods for identifying modulators of these genes or proteins and hence modulators of mitosis and meiosis.