Patents by Inventor David Glynn Smith

David Glynn Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazolopyridines and pyrazolopyridazines as antidiabetics
    Patent number: 7297792
    Abstract: The present invention includes compound of formula (I), or a derivative thereof, wherein Y is CH or N; R1 is unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted cycloalkenyl, unsubstituted or substituted aryl, aralkyl wherein the aryl and the alkyl moieties may each independently be unsubstituted or substituted, aralkenyl wherein the aryl, and alkenyl moieties may each independently be unsubstituted or substituted, unsubstituted or substituted heterocyclyl, or heterocyclylalkyl wherein the heterocyclcyl and the alkyl moieties may each inedepently be unsubstituted or substituted; and R2 is unsubstituted aryl or unsubstituted or substituted or substituted heteroaryl. Additionally the present invention inlcudes a process for preparing such a compound, a pharmaceutical composition containing such a compound, and the use of such a compound in medicine.
    Type: Grant
    Filed: June 6, 2006
    Date of Patent: November 20, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Stephen Garland, David Haigh, Deidre Mary Bernadette Hickey, John Liddle, David Glynn Smith, Robert William Ward, Jason Witherington
  • Pyrazolopyridines and pyrazolopyridazines as antidiabetics
    Patent number: 7109199
    Abstract: The present invention includes compound of formula (I), or a derivative thereof, wherein Y is CH or N; R1 is unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted cycloalkenyl, unsubstituted or substituted aryl, aralkyl wherein the aryl and the alkyl moieties may each independently be unsubstituted or substituted, aralkenyl wherein the aryl, and alkenyl moieties may each independently be unsubstituted or substituted, unsubstituted or substituted heterocyclyl, or heterocyclylalkyl wherein the heterocyclyl and the alkyl moieties may each independently be unsubstituted or substituted; and R2 is unsubstituted aryl or unsubstituted or substituted or substituted heteroaryl. Additionally the present invention includes a process for preparing such a compound, a pharmaceutical composition containing such a compound, and the use of such a compound in medicine.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: September 19, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Stephen Garland, David Haigh, Deidre Mary Bernadette Hickey, John Liddle, David Glynn Smith, Robert William Ward, Jason Witherington
  • Method and compounds
    Patent number: 6719520
    Abstract: A method for the treatment of conditions associated with a need for inhibition of GSK-3, such as diabetes, dementias such as Alzheimer's disease and manic depression which method comprises the administration of a pharmaceutically effective, non-toxic amount of a compound of formula (I): or a pharmaceutically acceptable derivative thereof, wherein: R is hydrogen, alkyl, aryl, or aralkyl; R1 is hydrogen, alkyl, aralkyl, hydroxyalkyl or alkoxyalkyl; R2 is substituted or unsubstituted aryl or substituted or unsubstituted heterocyclyl; R3 is hydrogen, substituted or unsubstituted alkyl, cycloalkyl, alkoxyalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl or aralkyl wherein the aryl moiety is substituted or unsubstituted; or, R1 and R3 together with the nitrogen to which they are attached form a single or fused, optionally substituted, saturated or unsaturated heterocylic ring; to a human or non-human mammal in need thereof, and compounds of formula I.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: April 13, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Matthew Paul Coghlan, Ashley Edward Fenwick, David Haigh, Julie Caroline Holder, Robert John Ife, Alastair David Reith, David Glynn Smith, Robert William Ward
  • Pyrazolopyridines and pyrazolopyridazines as antidabetics
    Publication number: 20040019052
    Abstract: The present invention includes compound of formula (I), 1
    Type: Application
    Filed: August 14, 2003
    Publication date: January 29, 2004
    Inventors: Stephen Garland, David Haigh, Deidre Mary Bernadette Hickey, John Liddle, David Glynn Smith, Robert William Ward, Jason Witherington
  • Novel method and compounds
    Publication number: 20040010031
    Abstract: A method for the treatment of conditions associated with a need for inhibition of GSK-3, such as diabetes, dementias such as Alzheimer's disease and manic depression which method comprises the administration of a pharmaceutically effective, non-toxic amount of a compound of formula (I): 1
    Type: Application
    Filed: May 28, 2003
    Publication date: January 15, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Matthew Paul Coghlan, Ashley Edward Fenwick, David Haigh, Julie Caroline Holder, Robert John Ife, Alastair David Reith, David Glynn Smith, Robert William Ward
  • Inhibitors of the production of S-CD23 and the secretion of TNF
    Patent number: 6235753
    Abstract: Inhibitors of the Production of s-CD23 and the secretion of TNF are provided.
    Type: Grant
    Filed: January 21, 1999
    Date of Patent: May 22, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Stuart Bailey, Andrew Faller, David Glynn Smith, Derek Richard Buckle
  • CD23 processing enzyme preparation
    Patent number: 6232089
    Abstract: The present invention is to the discovery of a novel CD23 processing enzyme which is of importance in the human immune response and regulation of IgE production, and is a protein expressed on the surface of a variety of cells.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: May 15, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Derek Richard Buckle, Gary Christie, Ariane Elizabeth Marolewski, Ruth Judik Mayer, David Glynn Smith