Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: A pneumatic tool for joining steel decking includes a pneumatic actuator assembly which drives a push rod. The push rod is coupled to a linkage assembly including a rocker link having one end coupled to the frame of the tool, a punch arm having one end coupled to the frame, and a coupler link rotatably coupled to both the rocker link and the punch arm. At the bottom of the tool, a punching mechanism is formed. A trigger mechanism releases a flow of pressurized air into the actuator assembly, thereby driving the push rod out of the housing of the actuator assembly. Movement of the push rod causes the rocker link to rotate about a joint link, thereby driving the coupler link toward the punch arm and causing the punch to rotate about the joint link and mate with the fixed die.

Abstract: A system comprises a storage system comprising one or more storage devices and a storage controller operatively coupled to the storage system, the storage controller comprising a processing device, the processing device to receive first raw data from a first tenant of the storage system to a first non-volatile memory express (NVMe) input/output (I/O) queue of the storage system. The processing device further to determine that the first NVMe I/O queue corresponds to a first key, wherein the first key corresponds to the first tenant. The processing device further to encrypt the first raw data using the first key to generate first encrypted data. The processing device further to store the first encrypted data on the storage system.

Abstract: A system and method for managing power consumption and storage in a power grid. Measurements are received from a plurality of geographically distributed energy management controllers. Each energy management controllers has energy storage units with stored energy. The measurements comprise the energy production and storage capacity of the energy management controllers and their associated energy storage units. The measurements are processed, e.g., aggregated, and displayed on a graphical user interface. Commands are transmitted to a first subset of the energy management controllers to command the units to discharge their stored energy into a power grid through an inverter. Commands are transmitted to a second subset of the plurality of energy management controllers to store energy in each unit's energy storage unit.

Abstract: A pneumatic tool for joining steel decking includes a pneumatic actuator assembly which drives a push rod. The push rod is coupled to a linkage assembly including a rocker link having one end coupled to the frame of the tool, a punch arm having one end coupled to the frame, and a coupler link rotatably coupled to both the rocker link and the punch arm. At the bottom of the tool, a punching mechanism is formed. A trigger mechanism releases a flow of pressurized air into the actuator assembly, thereby driving the push rod out of the housing of the actuator assembly. Movement of the push rod causes the rocker link to rotate about a joint link, thereby driving the coupler link toward the punch arm and causing the punch to rotate about the joint link and mate with the fixed die.

Abstract: Described herein are techniques optimizing queries on data in a data lake. The techniques involve ingesting data from multiple data lake sources, partitioning the data based on a key, and generating a partition index based on the key. The partition index can then be used to efficiently perform queries on data in the data lake.

Abstract: The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: A pneumatic tool for joining steel decking includes a pneumatic actuator assembly which drives a push rod. The push rod is coupled to a linkage assembly comprising a rocker link having one end rotatably coupled to the frame of the pneumatic tool, a punch arm having one end rotatably coupled to the frame, and a coupler link rotatably coupled to both the rocker link and the punch arm. At the bottom of the pneumatic tool, a punching mechanism is formed by a stationary die affixed to the frame and a movable jaw with a punch provided at the end of the punch arm. An operator may use a trigger mechanism to release a flow of pressurized air into the actuator assembly, thereby driving the push rod out of the housing of the actuator assembly. The end of the push rod is coupled to both the rocker link and the coupler link, so linear movement of the push rod out of the housing causes the rocker link to rotate about a joint link with the frame of the pneumatic tool, thereby driving the coupler link toward the punch arm.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilizing said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilizing said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates.

Abstract: A SAS expander or initiator places PHYs in a wide port into a persistent reduced power state by signaling to the connected SAS device that the SAS expander or initiator intends to route data traffic through other PHYs in the wide port. The SAS expander or initiator and connected SAS device agree to disuse certain PHYs so that the PHYs enter a reduced power state according to SAS standards.

Abstract: The present invention relates to a process for the manufacture of a compound of the Formula IIa: wherein R is a suitable sulphonate ester; from a (C1-C6)alkyl-4-piperidinecarboxylate compound of the Formula III:

Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.