Abstract: A filling system that supports a syringe with a drug and an implantable drug delivery system (IDDS), the filling system having: a filling fixture having a wall extending from a top to a bottom along a first axis and defining an outer wall surface and inner wall surface that are radially spaced from each other, wherein the inner wall surface defines a passage that includes: a top bore portion that is configured to seat the barrel bottom of the syringe; and a bottom bore portion configured to seat the ID DS such that the septum of the IDDS faces the syringe, wherein the top bore portion and the bottom bore portion are spaced apart from each other such that the needle of the syringe extends into the IDDS.

Abstract: A drug delivery assembly having: a housing having an outer wall, the outer wall having an outer surface and an inner surface, wherein the outer wall extends axially from a first end to a second end and defines a compartment configured to store a first drug; an opening in the housing, the opening positioned at the second end of the housing, with the opening in fluid communication with an area that is external to the housing; a first porous membrane positioned at the opening, wherein the outer wall and the first porous member define at least a part of an exterior of the assembly; and microprojections attached to the exterior of the assembly and configured to deliver a second drug to the area, wherein the second drug is the same as or different from the first drug.

Abstract: Disclosed herein are advantageous drug delivery assemblies, and related methods of fabrication and use thereof. The present disclosure provides improved drug delivery assemblies for extended drug delivery (e.g., via passive diffusion) and/or tunability, and improved systems/methods for utilizing and fabricating the drug delivery assemblies. More particularly, the present disclosure provides single or dual compartment, and dual porous membrane based (e.g., porous zinc membrane based) drug delivery assemblies for extended drug delivery (e.g., via passive diffusion) and/or tunability. The present disclosure also provides for a method for utilizing a drug delivery assembly. The assemblies can be utilized for the extended drug delivery of pharmaceuticals or the like, such as biologics, for the sustained release of medication for greater than six months to overcome difficulties with daily dosing regimes.