Patents by Inventor David Graham Brown

David Graham Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors
    Patent number: 9163021
    Abstract: The present invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as Trk antagonists.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: October 20, 2015
    Assignee: Pfizer Limited
    Inventors: Mark David Andrews, Sharanjeet Kaur Bagal, David Graham Brown, Karl Richard Gibson, Wolfgang Klute, Inaki Morao, Kiyoyuki Omoto, Thomas Ryckmans, Yogesh Sabnis, Sarah Elizabeth Skerratt, Paul Anthony Stupple
  • Pyrrolo[3,2-C]Pyridine Tropomyosin-Related Kinase Inhibitors
    Publication number: 20150246912
    Abstract: The present invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as Trk antagonists.
    Type: Application
    Filed: September 26, 2013
    Publication date: September 3, 2015
    Applicant: Pfizer Limited
    Inventors: Mark David Andrews, Sharanjeet Kaur Bagal, David Graham Brown, Karl Richard Gibson, Wolfgang Klute, Inaki Morao, Kiyoyuki Omoto, Thomas Ryckmans, Yogesh Sabnis, Sarah Elizabeth Skerratt, Paul Anthony Stupple
  • Pyrrolo[2,3-D]Pyrimidine Tropomyosin-Related Kinase Inhibitors
    Publication number: 20150218172
    Abstract: The present invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as Trk antagonists.
    Type: Application
    Filed: September 26, 2013
    Publication date: August 6, 2015
    Applicant: Pfizer Limited
    Inventors: Mark David Andrews, Sharanjeet Kaur Bagal, David Graham Brown, Karl Richard Gibson, Kiyoyuki Omoto, Thomas Ryckmans, Yogesh Sabnis, Sarah Elizabeth Skerratt, Paul Anthony Stupple
  • Pyrazolo[4,3-d]pyrimidines as phosphodiesterase inhibitors
    Patent number: 8097621
    Abstract: This invention relates to compounds of formula (I)
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: January 17, 2012
    Assignee: Pfizer Inc.
    Inventors: Andrew Simon Bell, David Graham Brown, Kevin Dack, David Nathan Abraham Fox, Ian Roger Marsh, Andrew Ian Morrell, Michael John Palmer, Carol Ann Winslow
  • Pyridine [3,4-b] pyrazinones
    Patent number: 7902195
    Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R2, R6A, R6B and R8 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: March 8, 2011
    Assignee: Pharmacia & Upjohn Company LLC
    Inventors: Robert O Hughes, Andrew Simon Bell, David Graham Brown, Dafydd Owen, Michael John Palmer, Christopher Phillips, David L. Brown, Yvette M. Fobian, John N. Freskos, Steven E. Heasley, E. Jon Jacobsen, Todd Maddux, Brent Mischke, John M. Molyneaux, Joseph B. Moon, D. Joseph Rogier, Jr., Michael B. Tollefson, John K. Walker
  • Novel Pharmaceuticals
    Publication number: 20090247539
    Abstract: This invention relates to compounds of formula (I)
    Type: Application
    Filed: June 10, 2009
    Publication date: October 1, 2009
    Inventors: Andrew Simon Bell, David Graham Brown, Kevin Dack, David Nathan Abraham Fox, Ian Roger Marsh, Andrew Ian Morrell, Michael John Palmer, Carol Ann Winslow
  • Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
    Patent number: 7572799
    Abstract: This invention relates to compounds of formula (I)
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: August 11, 2009
    Assignee: Pfizer Inc
    Inventors: Andrew Simon Bell, David Graham Brown, Kevin Dack, David Nathan Abraham Fox, Ian Roger Marsh, Andrew Ian Morrell, Michael John Palmer, Carol Ann Winslow
  • Pyrazolo[4,3-D]pyrimidines
    Patent number: 7569572
    Abstract: This invention relates to compounds of formula (I).
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: August 4, 2009
    Assignee: Pfizer Inc
    Inventors: Andrew Simon Bell, David Graham Brown, David Nathan Abraham Fox, Ian Roger Marsh, Andrew Ian Morrell, Dafydd Rhys Owen, Michael John Palmer, Carol Ann Winslow, Hwang Fun Lu, Thomas Edward Rogers
  • Pyrazolo[4,3-D]Pyrimidines
    Publication number: 20080293697
    Abstract: This invention relates to compounds of formula (I).
    Type: Application
    Filed: March 30, 2005
    Publication date: November 27, 2008
    Inventors: Andrew Simon Bell, David Graham Brown, David Nathan Abraham Fox, Ian Roger Marsh, Andrew Ian Morrell, Dafydd Rhys Owen, Michael John Palmer, Carol Ann Winslow, Hwang Fun Lu, Thomas Edward Rogers
  • Substituted pyrazolo[4,3-d]pyrimidines and their use as PDE-5 inhibitors
    Patent number: 7262192
    Abstract: The present invention comprises a class of 5,7-diaminopyrazolo[4,3-d]pyrimidine compounds. These compounds are useful as phosphodiesterase type 5 inhibitors. The present invention further comprises compositions containing the compounds use of the compounds and compositions to treat hypertension and other conditions, processes for the preparation of the compounds, and intermediates used in the preparation of the compounds.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: August 28, 2007
    Assignee: Pfizer Inc.
    Inventors: Andrew Simon Bell, David Graham Brown, David Nathan Abraham Fox, Ian Roger Marsh, Andrew Ian Morrell, Michael John Palmer, Carol Ann Winslow
  • Crystal structure
    Publication number: 20040082052
    Abstract: The present invention relates to the soakable crystal structures of a phosphodiesterase 5 (PDE5) and their uses in identifying PDE5 ligands, including PDE5 inhibitor compounds. The present invention also relates to methods of identifying such PDE5 inhibitor compounds and their medical use. The present invention additionally relates to crystals of PDE5 into which ligands may be soaked and crystals of PDE5 comprising PDE5 ligands that have been soaked into the crystal.
    Type: Application
    Filed: May 1, 2003
    Publication date: April 29, 2004
    Applicant: Pfizer Inc.
    Inventors: David Graham Brown, Colin Roger Groom, Andrew Lee Hopkins, Timothy Mark Jenkins, Sarah Helen Kamp, Margaret Mary O'Gara, Heather Joan Ringrose, Colin Mark Robinson, Wendy Elaine Taylor