Abstract: The inventors have determined that increasing the expression level or activity of FKBP-L polypeptide in a subject, which can be provided by expression of nucleic acids encoding FKBP-L or by providing FKBP-L polypeptides to a subject is advantageous for use in the treatment of obesity and obesity-related disorders. In particular increased expression or activity of FKBP-L polypeptide in a subject may be used to treat excessive weight gain (which can be characterised as obesity), glucose intolerance, diabetes and metabolic syndrome, which are closely linked to obesity and insulin resistance. FKBP-L can also be used as a biomarker for obesity and obesity-related disorders.

Abstract: A swinging-sliding door for use in interior doorways of buildings. The door mechanism includes first and second upper swing arms each having opposite inner and outer ends. The inner ends are rotatably mountable to first and second ends of the upper jamb member in the door frame for rotation in a substantially common horizontal plane between a closed position flush along the upper jamb member and an open position substantially perpendicular to the upper jamb member. The inner end of the second upper swing arm is mountable into substantially a corresponding intersection between the upper jamb member and a vertical jamb member. A slide having first and second ends is mounted in the upper channel of the door and so as to be aligned parallel with the upper jamb member. The slide has a length corresponding to the length of the upper channel of the door. The outer ends of said first and second swing arms are rotatably mounted respectively to said first and second ends of said slide.

Abstract: A method of managing a computer network includes comparing a first configuration file representing a network device configuration at a point in time with a second configuration file representing a network device configuration at an earlier point in time; and indicating when a difference exists between the first configuration file and the second configuration file. A system for managing a computer network comprises a memory in which is stored configuration files corresponding to plural network devices at plural points in time; a database in which is stored a history of configuration file usage; and an agent that retrieves from a network device a configuration file and determines when the configuration file retrieved differs from a stored configuration file corresponding to a different point in time.