Patents by Inventor David Griffith

David Griffith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IN VITRO EVOLUTION IN MICROFLUIDIC SYSTEMS
    Publication number: 20170282133
    Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.
    Type: Application
    Filed: May 5, 2017
    Publication date: October 5, 2017
    Inventors: Andrew David Griffiths, David A. Weitz, Darren R. Link, Keunho Ahn, Jerome Bibette
  • CAPSULE DISPENSING CONTAINER
    Publication number: 20170239186
    Abstract: A package for delivering a single-dose product includes a softgel capsule which is comprised of at least one gelling agent selected from protein-based gelling agents and polysaccharide-based gelling agents. The capsule shell includes one or more areas of reduced thickness that are preferentially ruptured by exertion of a compressive force on the softgel capsule to create an opening in the capsule shell through which the fill composition can be delivered by spraying or squeezing. A method for manufacturing the softgel capsule having one or more areas of reduced shell thickness is also described.
    Type: Application
    Filed: May 5, 2017
    Publication date: August 24, 2017
    Applicant: R.P. Scherer Technologies, LLC
    Inventors: Laura Baruzzi, David Griffith Williams, SR., Arianna Provenza, Rodrigo Fuscelli Pytel
  • Method of treating a patient for pain by administering an anti-ion channel antibody
    Patent number: 9738710
    Abstract: An anti-E1 ion channel antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: August 22, 2017
    Assignee: UCB Biopharma SPRL
    Inventors: Karen Margrete Miller, Marc Roger De Ryck, Christian Gilbert J. Wolff, Alastair David Griffiths Lawson, Helene Margaret Finney, Terence Seward Baker
  • Anti-aging nutritional supplement compositions for animals
    Patent number: 9682150
    Abstract: Anti-aging nutritional supplements for animals contain, in a carrier oil base, a carbon-60 fullerene compound or complex, biologically active phenols or polyphenols, asthaxanthin, chlorophyll or a chlorophyll derivative, coenzyme Q10, and mixed tocopherols and tocotrienols.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: June 20, 2017
    Assignee: NextGen Research
    Inventors: Marcus Louis Gitterle, Bevan Craig Elliott, Jonathan David Griffith
  • COMPARTMENTALISED SCREENING BY MICROFLUIDIC CONTROL
    Publication number: 20170102381
    Abstract: The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
    Type: Application
    Filed: October 21, 2016
    Publication date: April 13, 2017
    Inventors: Andrew David Griffiths, David A. Weitz, Darren Roy Link, Keunho Ahn, Jerome Bibette
  • Antibody molecules having specificity for human OX40
    Publication number: 20160355598
    Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
    Type: Application
    Filed: August 19, 2016
    Publication date: December 8, 2016
    Inventors: Alastair David Griffiths Lawson, Andrew Malcolm Nesbitt, Andrew George Popplewell, Stevan Graham Shaw, Diana Shpektor, Yi Zhang
  • ANTIBODY MOLECULES HAVING BINDING SPECIFICITY FOR HUMAN IL-13
    Publication number: 20160289323
    Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
    Type: Application
    Filed: June 13, 2016
    Publication date: October 6, 2016
    Inventors: Neil Gozzard, Alastair David Griffiths Lawson, Daniel John Lightwood, Roger Thomas Palframan, Bryan John Smith, Kerry Louise Tyson
  • Selection by compartmentalised screening
    Patent number: 9448172
    Abstract: The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a.) compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsules; and b.) identifying the compound which binds to or modulates the activity of the target. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
    Type: Grant
    Filed: September 29, 2005
    Date of Patent: September 20, 2016
    Assignee: Medical Research Council
    Inventors: Andrew David Griffiths, Chris Abell, Florian Hollfelder, Enrico Mastrobattista
  • Antibody molecules having specificity for human OX40
    Patent number: 9428570
    Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: August 30, 2016
    Assignee: UCB Pharma S.A.
    Inventors: Alastair David Griffiths Lawson, Andrew Malcolm Nesbitt, Andrew George Popplewell, Stevan Graham Shaw, Diana Shpektor, Yi Zhang
  • METHODS OF TREATING PAIN USING FUNCTION MODIFYING NAv1.7 ANTIBODIES
    Publication number: 20160222107
    Abstract: A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.
    Type: Application
    Filed: February 3, 2016
    Publication date: August 4, 2016
    Inventors: Helene Margaret Finney, Terence Seward Baker, Alastair David Griffiths Lawson, Karen Margrete Miller, Marc Roger de Ryck, Christian Gilbert J. Wolff
  • Prone cart
    Patent number: 9402773
    Abstract: A prone cart for transporting a patient in a hospital or clinic setting is provided. The prone cart includes a frame having a pair of extension slides coupled thereto and first and second sets of wheels. An upper portion includes first and second moveably adjustable trays operably coupled to said extension slides. The second tray includes a plurality of apertures in at least one side rail and the first tray includes at least one locking spring pin operably receivable by one of said plurality of apertures. The prone cart also includes a patient support surface.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: August 2, 2016
    Assignee: GILLETTE CHILDREN'S SPECIALTY HEALTHCARE
    Inventors: Lynda Woodman, Gary J. Kroll, Karen Cepress, Amy Schulz, Kath Roske, Paula Braaten, David Griffith
  • Hybrid Force Sensitive Touch Devices
    Publication number: 20160216842
    Abstract: A hybrid touch-screen display that integrates force-based touch-screen technology with any one from among a group of projective capacitive, surface capacitive, resistive, digital resistive, SAW, IR, APR, DST, optical and electromagnetic touch-screen technologies to provide an ability to compensate for non-perfect force transfer. An alternate implementation is also disclosed that employs a single force sensor for relative force measurement in a system in which force is traditionally not measured, here a water dispenser unit. This allows compensation for varying static loads, run-time calibration, and filtering of extraneous loads through firmware.
    Type: Application
    Filed: April 6, 2016
    Publication date: July 28, 2016
    Inventors: Anders L. Mölne, David Griffith
  • Method for obtaining antibodies
    Patent number: 9394357
    Abstract: A method of obtaining at least one recombinant antibody with improved affinity for a selected antigen from a family of antibodies which bind the selected antigen comprising: a) obtaining a family of two or more antibodies which bind the same antigen in which the VH CDR3 amino acid sequence of each antibody in the family is the same length and greater than 60% identical at the amino acid level; b) re-pairing the VH region of an antibody obtained in step (a) with the VL region from a different antibody obtained in step (a) to produce a new recombinant antibody; and c) screening the recombinant antibody produced in step (b) and selecting said antibody if it has improved affinity for the selected antigen compared to any one of the antibodies obtained in step (a).
    Type: Grant
    Filed: April 4, 2006
    Date of Patent: July 19, 2016
    Assignee: UCB Biopharma SPRL
    Inventor: Alastair David Griffiths Lawson
  • Isolated DNA sequences encoding, and methods for making, antibody molecules having binding specificity for human IL-13
    Patent number: 9394361
    Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing antibody molecules.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: July 19, 2016
    Assignee: UCB BIOPHARMA SPRL
    Inventors: Neil Gozzard, Alastair David Griffiths Lawson, Daniel John Lightwood, Roger Thomas Palframan, Bryan John Smith, Kerry Louise Tyson
  • METHODS FOR THE PRODUCTION OF DIATOM BIOMASS
    Publication number: 20160201025
    Abstract: The invention relates to methods of producing a diatom biomass. More particularly, the invention relates to methods to produce a diatom biomass using a continuous culture to produce a volumetric production rate of biomass of at least 20 g dry weight/L/day, wherein the culture medium is designed to provide the essential nutrients to maintain the diatom in log phase growth. In a preferred embodiment the biomass comprises highly unsaturated fatty acid.
    Type: Application
    Filed: November 21, 2013
    Publication date: July 14, 2016
    Inventors: Mark Humphrey Dines, Hywel David Griffiths, Moreland David Gibbs
  • IN VITRO EVOLUTION IN MICROFLUIDIC SYSTEMS
    Publication number: 20160186256
    Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.
    Type: Application
    Filed: February 1, 2016
    Publication date: June 30, 2016
    Inventors: Andrew David Griffiths, David A. Weitz, Darren R. Link, Keunho Ahn, Jerome Bibette
  • SMOKED FOOD, METHOD FOR SMOKING FOOD AND APPARATUS THEREFOR
    Publication number: 20160143328
    Abstract: Food for human consumption is smoked by providing smoke, removing one or more polycyclic aromatic hydrocarbons (PAHs) from the smoke and contacting the food with the treated smoke, or smoking the food and then removing the PAHs from the smoked food. PAH removal is selective, to remove the PAHs that contain 4 or more benzene rings, in particular without significantly changing the volatile profile of the smoked food. A selective filter is provided, as is apparatus comprising a smoke generator, a chamber in which to smoke food, and the selective filter, disposed between the smoke generator and the chamber.
    Type: Application
    Filed: July 15, 2014
    Publication date: May 26, 2016
    Inventors: Huw David Griffiths, David Allan Baines, Jane Ker Parker-Gray
  • Obtaining an Improved Therapeutic Ligand
    Publication number: 20160125124
    Abstract: Methods and associated apparatus involving designing a ligand ab initio that will bind to a binding site of a macromolecular target, or of identifying a modification to a ligand for improving the affinity of the ligand to a binding site of a macromolecular target, comprising using information about non-bonding, intra-molecular or inter-molecular atom to atom contacts extracted from a database of biological macromolecules to identify favoured regions adjacent to the binding site for particular atom types and modifying a candidate ligand to increase the intersection between atoms of the candidate ligand and the favoured regions. One or more steps of the methods may be performed by a computer.
    Type: Application
    Filed: June 13, 2014
    Publication date: May 5, 2016
    Inventors: Jiye Shi, Terence Seward Baker, Alastair David Griffiths Lawson, Xiaofeng Liu
  • Hybrid force sensitive touch devices
    Patent number: 9329719
    Abstract: A hybrid touch-screen display that integrates force-based touch-screen technology with any one from among a group of projective capacitive, surface capacitive, resistive, digital resistive, SAW, IR, APR, DST, optical and electromagnetic touch-screen technologies to provide an ability to compensate for non-perfect force transfer. An alternate implementation is also disclosed that employs a single force sensor for relative force measurement in a system in which force is traditionally not measured, here a water dispenser unit. This allows compensation for varying static loads, run-time calibration, and filtering of extraneous loads through firmware.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: May 3, 2016
    Assignee: Apple Inc.
    Inventors: Anders L. Mölne, David Griffith
  • Methods of treating pain using function modifying NA1.7 antibodies
    Patent number: 9266953
    Abstract: A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: February 23, 2016
    Assignee: UCB BIOPHARMA SPRL
    Inventors: Helene Margaret Finney, Terence Seward Baker, Alastair David Griffiths Lawson, Karen Margrete Miller, Marc Roger de Ryck, Christian Gilbert J. Wolff