Patents by Inventor David Griffiths
David Griffiths has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11942188Abstract: Methods and associated apparatus involving designing a ligand ab initio that will bind to a binding site of a macromolecular target, or of identifying a modification to a ligand for improving the affinity of the ligand to a binding site of a macromolecular target, comprising using information about non-bonding, intra-molecular or inter-molecular atom to atom contacts extracted from a database of biological macromolecules to identify favoured regions adjacent to the binding site for particular atom types and modifying a candidate ligand to increase the intersection between atoms of the candidate ligand and the favoured regions. One or more steps of the methods may be performed by a computer.Type: GrantFiled: March 18, 2020Date of Patent: March 26, 2024Assignee: UCB Biopharma SRLInventors: Jiye Shi, Terence Seward Baker, Alastair David Griffiths Lawson, Xiaofeng Liu
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Patent number: 11918407Abstract: Described is a method of providing an estimate of radiation dose received by a patient during an imaging scan performed by an imaging system. The method includes receiving patient information about the patient, receiving scan data generated during the imaging scan of the patient by the imaging system, creating a virtual dose model of the patient based upon the patient information and the scan data, receiving a selection of a region of interest of the patient, performing a dose simulation on the virtual dose model of the patient or a portion thereof, and determining, based upon an outcome of the dose simulation, an estimate of the radiation dose received within the region of interest. The imaging scan can be a partial imaging scan of a portion of the patient. Also provided is a system and software for carrying out this method.Type: GrantFiled: April 8, 2019Date of Patent: March 5, 2024Assignee: BAYER HEALTHCARE LLCInventors: David Griffiths, Arthur Uber, Jacob Agris, Ting Lu, Peter Thompson
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Patent number: 11919950Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.Type: GrantFiled: December 15, 2020Date of Patent: March 5, 2024Assignee: UCB BIOPHARMA SRLInventors: Ralph Adams, Terence Seward Baker, Alastair David Griffiths Lawson
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Publication number: 20240059679Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.Type: ApplicationFiled: October 9, 2023Publication date: February 22, 2024Applicant: Pfizer Inc.Inventors: Gary Erik Aspnes, Scott W. Bagley, John M. Curto, David James Edmonds, Mark E. Flanagan, Kentaro Futatsugi, David A. Griffith, Kim Huard, Yajing Lian, Chris Limberakis, Allyn T. Londregan, Alan M. Mathiowetz, David W. Piotrowski, Roger B. Ruggeri
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Publication number: 20240058437Abstract: The invention provides a human herpesvirus immunogenic peptide comprising a novel antigenic domain (AD) of glycoprotein B, termed AD-6. The invention also provides a nucleic acid sequence encoding said immunogenic peptide and an inhibitor that binds to said 5 immunogenic peptide. Also provided are an immunogenic composition, a pharmaceutical composition and a vaccine comprising said immunogenic peptide, nucleic acid sequence or inhibitor, and methods of treating or preventing a human herpesvirus infection.Type: ApplicationFiled: December 17, 2021Publication date: February 22, 2024Inventors: Matthew Bryan Reeves, Ilona Anna Baraniak, Paul David Griffiths
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Patent number: 11896352Abstract: A system and method for promoting and safeguarding the wellbeing of patients in relation to a fluid injection may obtain patient data; determine, based on the patient data, an initial risk prediction for a patient for a fluid injection to be administered to the patient, the initial risk prediction including a probability that the patient experiences at least one adverse event in response to the fluid injection; provide, to a user device, before the fluid injection is administered to the patient, the initial risk prediction; determine, after the fluid injection is started, sensor data associated with the patient; determine, based on the sensor data determined after the fluid injection is started, a current risk prediction including a probability that the patient experiences the at least one adverse event in response to the fluid injection; and provide, to the user device, the current risk prediction.Type: GrantFiled: April 30, 2021Date of Patent: February 13, 2024Assignee: BAYER HEALTHCARE LLCInventors: Johannes Anton Thuering, Arthur Uber, III, David Griffiths, Michael McDermott, Charles Lang, Linda Van Roosmalen, Barry Skirble, Adam Czibur, Daniel Moore, Vincenzo Caruso, Brandon Clarke
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Publication number: 20240034725Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.Type: ApplicationFiled: September 28, 2023Publication date: February 1, 2024Applicant: Pfizer Inc.Inventors: Gary Erik Aspnes, Scott W. Bagley, John M. Curto, Matthew S. Dowling, David Edmonds, Mark E. Flanagan, Kentaro Futatsugi, David A. Griffith, Kim Huard, Gajendra Ingle, Wenhua Jiao, Chris Limberakis, Alan M. Mathiowetz, David W. Piotrowski, Roger B. Ruggeri
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Publication number: 20240024520Abstract: The present disclosure relates to isolated fragments of antibodies, in particular to isolated knob domains of bovine ultralong CDR-H3 or portions thereof which bind to an antigen of interest, and formulations comprising the same. The disclosure further relates to the use of the isolated antibody fragments and formulations in therapy. The present disclosure also extends to methods of preparing said isolated antibody fragments.Type: ApplicationFiled: March 26, 2021Publication date: January 25, 2024Inventors: Alastair David Griffiths LAWSON, Alexander MACPHERSON, Anthony SCOTT-TUCKER, Anastasios SPILIOTOPOULOS
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Publication number: 20240027098Abstract: In one non-limiting embodiment, an apparatus is provided wherein the apparatus has a shell defining an interior volume, the shell having a first flange and a second flange. The apparatus may also be configured with an end cap having a connection flange, the end cap connected to the shell at the second flange. The apparatus may also be tunable to allow different heat amounts to be generated and exposed to fluid carried in tubes within the interior volume.Type: ApplicationFiled: December 3, 2020Publication date: January 25, 2024Inventors: David GRIFFITH, Lejun HE
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Patent number: 11873483Abstract: The disclosure provides methods and compositions useful for labeling of target molecules with origin-specific nucleic acid identifiers (for example, barcodes), which can be used subsequently to identify, quantify, or otherwise characterize a feature or activity of target molecules originating from a particular discreet volume. Such target molecules can include polypeptides expressed by cells, in which nucleic acid molecules encoding the polypeptides are labeled with the same, or matched, origin-specific nucleic acid identifiers.Type: GrantFiled: March 11, 2016Date of Patent: January 16, 2024Assignees: The Broad Institute, Inc., ÉCOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS (ESPCI PARIS TECH)Inventors: Robert Nicol, Andrew David Griffiths, Baptiste Saudemont, Timothy V. Kirk
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Patent number: 11858916Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.Type: GrantFiled: June 13, 2019Date of Patent: January 2, 2024Assignee: Pfizer Inc.Inventors: Gary Erik Aspnes, Scott W. Bagley, Edward L. Conn, John M. Curto, David J. Edmonds, Mark E. Flanagan, Kentaro Futatsugi, David A. Griffith, Kim Huard, Chris Limberakis, Alan M. Mathiowetz, David W. Piotrowski, Roger B. Ruggeri
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Patent number: 11826553Abstract: A fluid injector system for delivering a multi-phase fluid injection to a patient and methods of fluid delivery is disclosed. Methods of creating and using a multi-aspect fluid path impedance model of the injector system are used. Modeling and adjustment of factors that affect impedance and prevent or reduce backflow, reduce the likelihood of fluid flow rate spikes and provide more accurate flow rates and mixing ratios of fluids may be repeated or happen essentially continuously during an injection. The adjustments may be determined before the injection or determined and/or adjusted during the injection. The determination may include sensor feedback commonly used in injectors such as pressure and position feedback as well as other sensors. In all cases, the user can be notified of adjustments through on-screen notices and/or through the recordation of the injection data by a control device of the injector at the conclusion of the injection.Type: GrantFiled: September 28, 2021Date of Patent: November 28, 2023Assignee: BAYER HEALTHCARE LLCInventors: Arthur Uber, III, Chelsea Marsh, William Barone, Michael McDermott, Timothy Newing, Michael Spohn, Vince Delbrugge, Ralph Schriver, Kevin Cowan, David Griffiths
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Patent number: 11821109Abstract: The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.Type: GrantFiled: March 15, 2018Date of Patent: November 21, 2023Assignees: President and Fellows of Harvard College, United Kingdom Research and InnovationInventors: Andrew David Griffiths, David A. Weitz, Darren Roy Link, Keunho Ahn, Jerome Bibette
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Publication number: 20230366125Abstract: The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.Type: ApplicationFiled: April 24, 2023Publication date: November 16, 2023Inventors: Andrew David Griffiths, David A. Weitz, Darren Roy Link, Keunho Ahn, Jerome Bibette
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Publication number: 20230356734Abstract: Techniques for performing a sensor calibration using sequential data is disclosed. An example method includes receiving, from a first camera located on a vehicle, a first image comprising at least a portion of a road comprising lane markers, where the first image is obtained by the camera at a first time; obtaining a calculated value of a position of an inertial measurement (IM) device at the first time; obtaining an optimized first extrinsic matrix of the first camera by adjusting a function of a first actual pixel location of a location of a lane marker in the first image and an expected pixel location of the location of the lane marker; and performing autonomous operation of the vehicle using the optimized first extrinsic matrix of the first camera when the vehicle is operated on another road or at another time.Type: ApplicationFiled: July 10, 2023Publication date: November 9, 2023Inventors: Shane David GRIFFITH, Chenghao GONG, Chenzhe QIAN
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Patent number: 11802121Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.Type: GrantFiled: October 24, 2022Date of Patent: October 31, 2023Assignee: Pfizer Inc.Inventors: Gary Erik Aspnes, Scott W. Bagley, John M. Curto, Matthew S. Dowling, David Edmonds, Mark E. Flanagan, Kentaro Futatsugi, David A. Griffith, Kim Huard, Gajendra Ingle, Wenhua Jiao, Chris Limberakis, Alan M. Mathiowetz, David W. Piotrowski, Roger B. Ruggeri
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Patent number: 11786872Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.Type: GrantFiled: May 1, 2020Date of Patent: October 17, 2023Assignees: UNITED KINGDOM RESEARCH AND INNOVATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Andrew David Griffiths, David A. Weitz, Darren Roy Link, Keunho Ahn, Jerome Bibette
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Publication number: 20230287873Abstract: A pumping assembly includes at least one removable unit barrel pumping assembly coupled to a housing of the pumping assembly. The pumping assembly further includes a drive member having a roller configured to engage a portion of the unit barrel pumping assembly during operation of the pumping assembly. The roller is configured to include a plurality of geometric shapes to distribute load forces during operation of the pumping assembly.Type: ApplicationFiled: May 17, 2023Publication date: September 14, 2023Inventors: Donald J. Benson, Eric A. Benham, Ahmad M. Sabri, Samuel David Griffith Magnuson
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Publication number: 20230262169Abstract: A system and method provide audio processing for on-line communications, including the elimination of unwanted and disruptive noises, enhancing the clarity of the participants voices, and further processing to establish an immersive 3D spatial audio experience. The combination of the three main processing components which make up the Core and the processes of how audio streams and related data are manipulated leveraging machine learning algorithms and finely tuned component configurations to establish a clear, immersive on-line audio communication listening experience for each participant is a primarily unique feature of the present invention.Type: ApplicationFiled: February 14, 2023Publication date: August 17, 2023Applicant: Immersitech, Inc.Inventors: Isaac Weston Mosebrook, David Frederick Horan, Ian David Griffith Lawson
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Publication number: 20230235729Abstract: The present disclosure provides a high-pressure fuel pump having barrel sets comprising offset, opposing barrel units within the same plane and having plungers disposed therein. The high-pressure fuel pump further includes a camshaft having at least one offset lobe and a cam ring encircling the lobe and in contact with the plungers, which translate the rotational movement of the camshaft to longitudinal movement of the plungers, controlling inflow, compression, and outflow of fuel within the pump.Type: ApplicationFiled: March 11, 2020Publication date: July 27, 2023Inventors: Eric A. Benham, Mustafa Utku Unal, Donald J. Benson, Samuel David Griffith Magnuson, Benjamin Scott Myser