Abstract: A flexure carriage assembly (24) has a carriage (25) formed of a substantially rigid material. The carriage has four elongate columns (32A, 32B, 32C, 32D) arranged spaced apart and parallel to one another. Each of the elongate columns has first and second ends. The flexure carriage (25) has four first cross members disposed between adjacent pairs of elongate columns and arranged to interconnect the first ends. The flexure carriage also includes four second cross members (38A-D) arranged between adjacent pairs of elongate columns and arranged to interconnect the bottom ends. The elongate columns and first and second cross members define a three-dimensional rectangular structure. The flexure carriage also has disposed centrally between the four elongate columns a translating section (29) spaced equidistant between the first and second ends of the columns.

Abstract: A broadcast control apparatus for visual data includes a touch screen (32, 34) display panel operable to receive and display visual data simultaneously in real time from a plurality of visual sources. It also includes a touch screen graphical panel for the retrieval of control functions from a control function register. The visual data from at least one of the visual sources is selectable for use by finger pressure on the associated portion of the touch screen (32, 34) display panel and the selected data is modifiable in accordance with the retrieved control function.

Abstract: A multistage optical amplifier is controlled to compensate for the effect of amplified spontaneous emission (ASE) by a method comprising the following steps. Optical input and output signals to a first gain stage are detected, and the drive current to the first gain stage is controlled in dependence on the optical input signal to the first gain stage. Optical input and output signals to a last gain stage are detected, and the drive current to the last gain stage is controlled to maintain the output power of the last gain stage substantially constant. The effect of ASE in the first gain stage is compensated for by applying a correction factor based on the ASE of the first gain stage and the output power of the first gain stage.

Abstract: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

Abstract: An interferometry method includes: imaging test light reflected from at least a first portion of a test surface to interfere with reference light on a camera and form an interference pattern, wherein the imaging defines a depth of focus for the light reflected from the test surface, and wherein the test light and reference light are derived from a common source; varying an optical path length difference between the test light and reference light over a range larger than the depth of focus, wherein the optical path length difference corresponds to a difference between a first optical path between the common source and the camera for the test light and a second optical path between the common source and the camera for the reference light; and maintaining the first portion of the test surface within the depth of focus as the optical path length difference is varied.

Abstract: A flexure carriage assembly (24) has a carriage (25) formed of a substantially rigid material. The carriage has four elongate columns (32A, 32B, 32C, 32D) arranged spaced apart and parallel to one another. Each of the elongate columns has first and second ends. The flexure carriage (25) has four first cross members disposed between adjacent pairs of elongate columns and arranged to interconnect the first ends. The flexure carriage also includes four second cross members (38A-D) arranged between adjacent pairs of elongate columns and arranged to interconnect the bottom ends. The elongate columns and first and second cross members define a three-dimensional rectangular structure. The flexure carriage also has disposed centrally between the four elongate columns a translating section (29) spaced equidistant between the first and second ends of the columns.

Abstract: A flexure carriage assembly (24) has a carriage (25) formed of a substantially rigid material. The carriage has four elongate columns (32A, 32B, 32C, 32D) arranged spaced apart and parallel to one another. Each of the elongate columns has first and second ends. The flexure carriage (25) has four first cross members disposed between adjacent pairs of elongate columns and arranged to interconnect the first ends. The flexure carriage also includes four second cross members (38A–D) arranged between adjacent pairs of elongate columns and arranged to interconnect the bottom ends. The elongate columns and first and second cross members define a three-dimensional rectangular structure. The flexure carriage also has disposed centrally between the four elongate columns a translating section (29) spaced equidistant between the first and second ends of the columns.

Abstract: This invention relates to an ink jet printing method comprising the steps of: A) providing an ink jet printer that is responsive to digital data signals; B) providing an ink jet printhead comprising a nozzle array comprising a plurality of nozzles, said nozzle array being dedicated to ejecting a given ink jet ink composition, wherein said nozzles are 20 microns or less in diameter; C) supplying said printhead with said given ink jet ink composition, said ink jet ink composition comprising particles wherein at least 90% by weight of said particles have a diameter that is less than 1/120th of the diameter of said nozzles; and D) printing using said given ink jet ink composition in response to said digital data signals.

Abstract: An interferometry method includes: imaging test light reflected from at least a first portion of a test surface to interfere with reference light on a camera and form an interference pattern, wherein the imaging defines a depth of focus for the li ght reflected from the test surface, and wherein the test light and reference light are derived from a common source; varying an optical path length difference between the test light and reference light over a range larger than the depth of focus, wherein the optical path length difference corresponds to a difference between a first optical path between the common source and the camera for the test light and a second optical path between the common source and the camera for the reference light; and maintaining the first portion of the test surface within the depth of focus as the optical path length difference is varied.

Abstract: The invention features a method for determining a geometric property of a test object, the method including: interferometrically profiling a first surface of the test object in a first coordinate system; interferometrically profiling a second surface of the test object in a second coordinate system different from the first coordinate system; providing a relationship between the first and second coordinate system; and calculating the geometric property based on the interferometrically profiled surfaces and the relationship between the first and second coordinate system. In some embodiments, the relationship may be determined by using calibrated gage blocks or by using a displacement measuring interferometer. Corresponding system are also described.

Abstract: A flexure carriage assembly (24) has a carriage (25) formed of a substantially rigid material. The carriage has four elongate columns (32A, 32B, 32C, 32D) arranged spaced apart and parallel to one another. Each of the elongate columns has first and second ends. The flexure carriage (25) has four first cross members disposed between adjacent pairs of elongate columns and arranged to interconnect the first ends. The flexure carriage also includes four second cross members (38A-D) arranged between adjacent pairs of elongate columns and arranged to interconnect the bottom ends. The elongate columns and first and second cross members define a three-dimensional rectangular structure. The flexure carriage also has disposed centrally between the four elongate columns a translating section (29) spaced equidistant between the first and second ends of the columns.

Abstract: The invention relates a nucleic acid and its encoded polypeptide ESM-1, whose expression is modulated in angiogenesis and oncogenesis. The invention also relates to antibodies having specificity for said polypeptide. The present invention also relates to antisense molecules. The invention further relates to methods useful for treating or modulating angiogenesis in mammals in need of such biological effect.

Abstract: A flexure carriage assembly (24) has a carriage (25) formed of a substantially rigid material. The carriage has four elongate columns (32A, 32B, 32C, 32D) arranged spaced apart and parallel to one another. Each of the elongate columns has first and second ends. The flexure carriage (25) has four first cross members disposed between adjacent pairs of elongate columns and arranged to interconnect the first ends. The flexure carriage also includes four second cross members (38A-D) arranged between adjacent pairs of elongate columns and arranged to interconnect the bottom ends. The elongate columns and first and second cross members define a three-dimensional rectangular structure. The flexure carriage also has disposed centrally between the four elongate columns a translating section (29) spaced equidistant between the first and second ends of the columns.

Abstract: The invention relates generally to the identification of nucleic acids and their encoded polypeptides, particularly VCC1, whose expression is modulated in angiogenesis. These nucleic acids and proteins have not previously been identified as having a biological role in angiogenesis. The invention further relates to compounds that modulate VCC1 expression and/or activity. Methods of using these compounds for modulation of VCC-1 expression and for treatment of diseases associated with expression of VCC-1 are provided. Also included are methods of diagnosis of VCC1 associated angiogenic disorders.

Abstract: A flexure carriage assembly (24) has a carriage (25) formed of a substantially rigid material. The carriage has four elongate columns (32A, 32B, 32C, 32D) arranged spaced apart and parallel to one another. Each of the elongate columns has first and second ends. The flexure carriage (25) has four first cross members disposed between adjacent pairs of elongate columns and arranged to interconnect the first ends. The flexure carriage also includes four second cross members (38A-D) arranged between adjacent pairs of elongate columns and arranged to interconnect the bottom ends. The elongate columns and first and second cross members define a three-dimensional rectangular structure. The flexure carriage also has disposed centrally between the four elongate columns a translating section (29) spaced equidistant between the first and second ends of the columns.

Abstract: A flexure carriage assembly has a carriage formed of a substantially rigid material. The carriage has four elongate columns arranged spaced apart and parallel to one another. Each of the elongate columns has first and second ends. The flexure carriage has four first cross members disposed between adjacent pairs of elongate columns and arranged to interconnect the first ends. The flexure carriage also includes four second cross members arranged between adjacent pairs of elongate columns and arranged to interconnect the bottom ends. The elongate columns and first and second cross members define a three-dimensional rectangular structure. The flexure carriage also has disposed centrally between the four elongate columns a translating section spaced equidistant between the first and second ends of the columns.

Abstract: A method of tuning or trimming a flexure stage to substantially constrain a workpiece carried by the flexure stage's free end from moving along an axis of motion that does not contain a desired path of free end travel. In the case of an XY flexure stage, measures are incorporated into the flexure stage to prevent simple out-of-plane motion (either linear or non-linear), rolling, pitching, or combinations of all three, as well as out-of-axis motion where desired. A preferred tuning technique begins with initially aligning the flexure stage's actuator so that its highest off-axis force component extends as much as possible within the plane of desired motion, followed by positioning the actuator on the flexure stage so as to eliminate as much as possible simple out-of-plane motion and accompanied if necessary by incorporating additional measures to eliminate as much as possible roll or pitch motion and residual simple out-of-plane motion.

Abstract: The bandwidth of a microactuator for a surface modification instrument or a surface measurement instrument is improved by inertially-balancing the microactuator to prevent the transfer of any net forces from the microactuator to its support structure by counteracting momentum generated upon operation of the microactuator, thereby inhibiting induced resonances in the support structure. Net force transfer prevention can be achieved using either 1) a multi-actuator assembly including a primary microactuator and a counteracting actuator operating substantially out-of-phase with respect to the primary microactuator, or 2) a single microactuator mounted on the microactuator's support structure so as to prevent momentum transfer to the support structure during microactuator operation. The instrument also preferably includes high internal damping to minimize the effect of any slight inertial misbalances on instrument operation.

Abstract: The invention features a method for determining a geometric property of a test object, the method including: interferometrically profiling a first surface of the test object in a first coordinate system; interferometrically profiling a second surface of the test object in a second coordinate system different from the first coordinate system; providing a relationship between the first and second coordinate system; and calculating the geometric property based on the interferometrically profiled surfaces and the relationship between the first and second coordinate system. In some embodiments, the relationship may be determined by using calibrated gage blocks or by using a displacement measuring interferometer. Corresponding system are also described.

Abstract: A flexure carriage assembly has a carriage formed of a substantially rigid material. The carriage has four elongate columns arranged spaced apart and parallel to one another. Each of the elongate columns has first and second ends. The flexure carriage has four first cross members disposed between adjacent pairs of elongate columns and arranged to interconnect the first ends. The flexure carriage also includes four second cross members arranged between adjacent pairs of elongate columns and arranged to interconnect the bottom ends. The elongate columns and first and second cross members define a three-dimensional rectangular structure. The flexure carriage also has disposed centrally between the four elongate columns a translating section spaced equidistant between the first and second ends of the columns.