Patents by Inventor David Guez
David Guez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240100326Abstract: A system and a method for increasing permeability of a brain barrier selected from a blood-brain barrier or a blood-cerebrospinal fluid barrier by controlled application of pulsed electric fields.Type: ApplicationFiled: November 30, 2023Publication date: March 28, 2024Inventors: Yael MARDOR, Shirley SHARABI, Itzik COOPER, David LAST, David GUEZ, Dianne DANIELS ELMAKIAS, Yael BRESLER
-
Patent number: 11931569Abstract: A system and a method for increasing permeability of a brain barrier selected from a blood-brain barrier or a blood-cerebrospinal fluid barrier by controlled application of pulsed electric fields.Type: GrantFiled: March 12, 2019Date of Patent: March 19, 2024Assignee: TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE & SERVICES LTD.Inventors: Yael Mardor, Shirley Sharabi, Itzik Cooper, David Last, David Guez, Dianne Daniels Elmakias, Yael Bresler
-
Patent number: 11933866Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.Type: GrantFiled: August 13, 2020Date of Patent: March 19, 2024Assignees: Tel Hashomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Yael Mardor, Leor Zach, David Guez, David Last, Dianne Daniels Elmakias
-
Patent number: 11892530Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.Type: GrantFiled: August 13, 2020Date of Patent: February 6, 2024Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Yael Mardor, Leor Zach, David Guez, David Last, Dianne Daniels Elmakias
-
Patent number: 10970594Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.Type: GrantFiled: February 20, 2019Date of Patent: April 6, 2021Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Leor Zach, David Guez, David Last, Dianne Daniels Elmakias, Yael Mardor, Shirley Sharabi, Noam Nissan, Miriam Sklair-Levy
-
Publication number: 20210016084Abstract: A system and a method for increasing permeability of a brain barrier selected from a blood-brain barrier or a blood-cerebrospinal fluid barrier by controlled application of pulsed electric fields.Type: ApplicationFiled: March 12, 2019Publication date: January 21, 2021Inventors: Yael MARDOR, Shirley SHARABI, Itzik COOPER, David LAST, David Guez, Dianne DANIELS ELMAKIAS, Yael BRESLER
-
Publication number: 20200371174Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.Type: ApplicationFiled: August 13, 2020Publication date: November 26, 2020Applicants: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Yael MARDOR, Leor ZACH, David GUEZ, David LAST, Dianne DANIELS ELMAKIAS
-
Publication number: 20200371173Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.Type: ApplicationFiled: August 13, 2020Publication date: November 26, 2020Applicants: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Yael MARDOR, Leor ZACH, David GUEZ, David LAST, Dianne DANIELS ELMAKIAS
-
Patent number: 10809323Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.Type: GrantFiled: April 24, 2014Date of Patent: October 20, 2020Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Remot at Tel-Aviv University Ltd.Inventors: Yael Mardor, Leor Zach, David Guez, David Last, Dianne Daniels
-
Publication number: 20190180139Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.Type: ApplicationFiled: February 20, 2019Publication date: June 13, 2019Applicants: Tel HaShomer Medical Research Infrastructure and S ervices Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Leor ZACH, David GUEZ, David LAST, Dianne DANIELS ELMAKIAS, Yael MARDOR
-
Patent number: 10275680Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.Type: GrantFiled: October 18, 2012Date of Patent: April 30, 2019Assignees: Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Leor Zach, David Guez, David Last, Dianne Daniels, Yael Mardor
-
Publication number: 20170247429Abstract: The present invention relates to blood-brain barrier disrupting agents containing a modified serum albumin comprising serum albumin. The present invention further relates to pharmaceutical compositions comprising said agents and use thereof for the treatment of brain diseases and disorders.Type: ApplicationFiled: September 16, 2015Publication date: August 31, 2017Inventors: Itzik Cooper, David Guez, David Last, Yoram Shechter, Matityahu Fridkin, Yael Mardor
-
Publication number: 20160109539Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.Type: ApplicationFiled: April 24, 2014Publication date: April 21, 2016Applicants: Tel HaShomer Medical Research Infrasture and Services Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Yael MARDOR, Leor ZACH, David GUEZ, David LAST, Dianne DANIELS
-
Publication number: 20140270451Abstract: Apparatus for analyzing brain MRI, is disclosed. The apparatus comprises an input for receiving a first and a second MRI scans at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from said first and said second MRI scans by analyzing said scans to distinguish between two primary populations, a slow population, in which contrast clearance from the tissue is slower than contrast accumulation, and a fast population in which clearance is faster than accumulation; and an output to provide an indication of distribution of said two primary populations, wherein said predetermined time period is at least twenty minutes.Type: ApplicationFiled: October 18, 2012Publication date: September 18, 2014Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.Inventors: Leor Zach, David Guez, David Last, Dianne Daniels, Yael Mardor
-
Patent number: 6653336Abstract: The present invention relates to the use of a combination of an antiotensin-converting enzyme inhibitor (CEI) and of a diuretic for the treatment of arteriolo-capillary microcirculatory disorders and to pharmaceutical compositions containing the same.Type: GrantFiled: May 18, 2000Date of Patent: November 25, 2003Assignee: Les Laboratoires ServierInventors: David Guez, Pierre Schiavi, Bernard Levy
-
Patent number: 5334392Abstract: The invention relates to a matrix tablet for the sustained release of indapamide which ensures a continuous and uniform release of the active principle after oral administration.Type: GrantFiled: June 9, 1992Date of Patent: August 2, 1994Assignee: Adir et CompagnieInventors: Alain Cuine, Bruno H. de Barochez, David Guez