Abstract: A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.

Abstract: Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound described therein.

Abstract: The present invention is for an acidic cleaning composition which has excellent cleaning performance, low toxicity and good antimicrobial efficacy. The inventive acidic cleaning compositions are capable of sanitizing or disinfecting a variety of hard surfaces. The inventive acidic cleaning compositions can take a variety of forms, such as: disinfecting wipes, all-purpose disinfecting sprays, kitchen cleaners, bathroom cleaners, toilet cleaners, etc. The compositions may meet EPA DfE requirements, EPA category III or IV requirements, and/or be safe for use on food contact surfaces without rinsing. The compositions may include citric acid, an anionic surfactant, a non-volatile glycol solvent, a fatty acid, and water. The compositions may be free of other sanitizing acids, quaternary ammonium compounds, biguanides, peroxides, hypohalites, etc., and have a pH of less than 2.5. The composition may provide sanitization or disinfection against a target microbe within 5 minutes or less, or 4 minutes or less.

Abstract: Inverse temperature crystallization processes are provided to produce perovskite single crystals (PSCs), as well as surface passivation techniques for producing stabilizing the PSCs in the bulk region. Stable hybrid perovskite material include a bulk region comprising a single crystal perovskite material having a first bandgap and a smooth perovskite surface layer having a second bandgap greater than the first bandgap. Devices for detection and energy conversion are also contemplated, including for spectroscopic photon and elementary particle detection, such as radiation detectors. Crystallization chambers for forming the PSCs are also provided.

Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.

Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: Peroxide treatment compositions for use in laundry capable of providing sanitization through the wash e.g., for use with a detergent, where a peroxide activator is stabilized without the presence of phosphorus-containing compounds (e.g., phosphorus-containing stabilizers), through use of a nonionic surfactant (e.g., alkoxylated alcohol) with a cloud point above 45° C. Use of a single nonionic surfactant, or a surfactant package that may include a small fraction (e.g., less than 0.5%) of sodium lauryl sulfate or another anionic surfactant has been found to be surprisingly effective at stabilizing the peroxide/activator combination, even where water content may be 85% or greater. The composition can have a pH of 5 or less (e.g., 3 to 4). The composition may be free of other anionic surfactants, cationic surfactants, zwitterionic surfactants, amphoteric surfactants, magnesium salts, borates and boric acid, hydroxides, chelating agents, various amine oxides, ethoxylated amines, and the like.

Abstract: Compositions of P4HB with high purity have been developed. The compositions are prepared by washing P4HB biomass prior to solvent extraction, and precipitating P4HB from solution. The same solvent is preferably used to wash the P4HB biomass, and as a non-solvent to precipitate the polymer from a P4HB solvent solution. The highly pure P4HB compositions are suitable for preparing implants. The implants may be used for the repair of soft and hard tissues.

Abstract: The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of Aß plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.

Abstract: Technologies for data capture and data analysis include a system having a knowledge repository in which all input data is stored as objects and relationships between objects, and each object represents at least one container of one or more properties. The knowledge repository is capable of storing the input data according to more than one storage format. The system may also include a user interface providing an input mechanism to obtain the input data, object information that defines one or more of the properties, and relationship information that defines one or more of the relationships. The system includes a controller configured to receive the input data, the object information, and the relationship information from the user interface and to cause the input data to be stored in the knowledge repository as at least one object based on the object information and the relationship information.

Abstract: Biguanide compounds of formula where R1 comprises a cubanyl-substituted alkyl and R2 comprises a substituted or unsubstituted alkyl, and their use in the treatment of cancers and viral infections are described.

Abstract: To answer if a user is a transitive member of a group efficiently, a method to maintain each node's ancestors or descendants is disclosed. The system maintains each node's ancestor paths or descendant paths and update affected nodes when a child node is added to or removed from the parent node. The affected nodes are the child and the child's descendants in the case of ancestor paths. The affected nodes are the parent and the parent's ancestors in the case of descendant paths. The node's ancestors or descendants are the unique nodes in the ancestor paths or descendant paths. Hybrid approaches can be used to reduce change volumes by skipping users.

Abstract: The present disclosure provides a cartridge, a battery assembly and an electronic cigarette. The cartridge, includes: a liquid absorbing assembly, and a liquid container for supplying tobacco liquid to the liquid absorbing element, the liquid absorbing element is arranged below the liquid container, the liquid absorbing assembly is arranged in such a manner that the tobacco liquid is kept in the liquid container or the liquid absorbing element before the cartridge is assembled at an in-use state.

Abstract: The present disclosure provides a cartridge, a battery assembly and an electronic cigarette. The cartridge, includes: a liquid absorbing assembly, and a liquid container for supplying tobacco liquid to the liquid absorbing element, the liquid absorbing element is arranged below the liquid container, the liquid absorbing assembly is arranged in such a manner that the tobacco liquid is kept in the liquid container or the liquid absorbing element before the cartridge is assembled at an in-use state.

Abstract: The present disclosure provides a cartridge, a battery assembly and an electronic cigarette. The cartridge, includes: a liquid absorbing assembly, and a liquid container for supplying tobacco liquid to the liquid absorbing element, the liquid absorbing element is arranged below the liquid container, the liquid absorbing assembly is arranged in such a manner that the tobacco liquid is kept in the liquid container or the liquid absorbing element before the cartridge is assembled at an in-use state.

Abstract: Systems, methods, and apparatuses are presented for an e-cigarette device that atomizes the liquid through ultrasonic vibrations, thereby generating micro-droplets that can be absorbed through breathing, similar to breathing in a mist or vapor. No heating elements are involved, thereby leading to no burnt elements and reducing second-hand smoke effects.

Abstract: An atomizer for use with vaporizers and electronic cigarettes, the atomizer comprising an inhaler having a first end and a second end through both of which air flow passage partially extends; a chamber coupled to said second end of said inhaler; a heating element positioned within the chamber to be in contact with a liquid; a liquid absorber coupled to the heating element; and a receiver to receive the heating element, wherein the receiver has at least one conductive contact, and the receiver comprises a power connection connectable to a power supply.

Abstract: Systems, methods, and apparatuses are presented for an e-cigarette device that atomizes the liquid through ultrasonic vibrations, thereby generating micro-droplets that can be absorbed through breathing, similar to breathing in a mist or vapor. No heating elements are involved, thereby leading to no burnt elements and reducing second-hand smoke effects.