Patents by Inventor David H. Combs

David H. Combs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12656364
    Abstract: A receptacle delivery system for an instrument includes a carriage, a puck rotatably supported by the carriage, a first electric motor, and a second electric motor. The puck comprises a plurality of spring-loaded fingers arranged around a vertical axis and configured to removably support a receptacle therebetween. The first electric motor is configured to move the carriage between a first location and a second location of the instrument. The second electric motor is configured to rotate the puck about the vertical axis.
    Type: Grant
    Filed: February 29, 2024
    Date of Patent: June 16, 2026
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Rolf Silbert, HongRan Peng, David Aaron Buse, David H. Combs
  • Patent number: 12656365
    Abstract: Delivering a receptacle to an instrument comprises supporting a receptacle in a carriage when the carriage is positioned at a first location of the instrument, activating a sensing system coupled to the carriage to confirm that the receptacle is supported by the carriage, moving the carriage, and the receptacle supported therein, to a second location of the instrument, applying a clamping force to the receptacle as the carriage moves from the first location to the second location, at the second location, extracting at least a portion of a fluid contained in the receptacle using a fluid extraction device of the instrument, moving the carriage, and the receptacle supported therein, from the second location to the first location, and releasing the clamping force from the receptacle as the carriage moves from the second location to the first location.
    Type: Grant
    Filed: May 7, 2024
    Date of Patent: June 16, 2026
    Assignees: Gen-Probe Incorporated, Grifols, S.A.
    Inventors: Rolf Silbert, HongRan Peng, David Aaron Buse, David H. Combs
  • Patent number: 12546794
    Abstract: Providing a fluid to an instrument comprises supporting a sample receptacle on a first carrier, transporting the first carrier on a conveyor adjacent a plurality of modules including at least one instrument, stopping the first carrier at the instrument, transporting the sample receptacle to a pick-up position of the instrument, transporting the sample receptacle from the pick-up position to a pipetting station within the instrument, aspirating fluid within the sample receptacle and transferring the aspirated fluid to a reaction receptacle, after aspirating fluid from the sample receptacle, transporting the sample receptacle to the pick-up position, transporting the sample receptacle from the pick-up position to a second carrier the conveyor, in the instrument, performing an assay to determine the presence or absence of an analyte in the aspirated fluid, and transporting the second carrier on the conveyor to one or more of the plurality of modules other than the analytical instrument.
    Type: Grant
    Filed: May 7, 2024
    Date of Patent: February 10, 2026
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Rolf Silbert, HongRan Peng, David Aaron Buse, David H. Combs
  • Publication number: 20250271457
    Abstract: A receptacle clamping mechanism of an instrument includes a carriage configured to move between a first location and a second location of the instrument. The carriage includes one or more support members configured to removably support a receptacle therebetween and a pair of opposed support pads configured to apply a clamping force to a receptacle supported by the carriage as the carriage moves from the first location to the second location and release the clamping force from the receptacle as the carriage moves from the second location to the first location. The clamping mechanism further includes a sensing system configured to determine whether a receptacle is supported by the carriage.
    Type: Application
    Filed: May 2, 2025
    Publication date: August 28, 2025
    Applicant: Gen-Probe Incorporated
    Inventors: Rolf SILBERT, HongRan PENG, David Aaron BUSE, David H. COMBS
  • Patent number: 12392791
    Abstract: A receptacle delivery system for an instrument includes a carriage, a puck supported by the carriage, and a first shelf. The carriage is configured to move from a first location of the instrument to a second location of the instrument. The puck is configured to removably support a receptacle such that a longitudinal axis of the receptacle is substantially coincident with a vertical axis of the puck. The first shelf comprises (a) a base extending substantially transverse to the vertical axis of the puck and (b) a first opening defined by the base, and when the carriage is positioned at the second location, the longitudinal axis of a receptacle seated in the puck extends through the first opening.
    Type: Grant
    Filed: January 31, 2024
    Date of Patent: August 19, 2025
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Rolf Silbert, HongRan Peng, David Aaron Buse, David H. Combs
  • Patent number: 12392792
    Abstract: A method of delivering a receptacle to an instrument includes the steps of supporting a receptacle in a carriage, activating an electric motor to move the carriage between a first location and a second location of the instrument while the receptacle is supported by the carriage, applying a clamping force to the receptacle as the carriage moves from the first location to the second location, and releasing the clamping force from the receptacle as the carriage moves from the second location to the first location.
    Type: Grant
    Filed: February 29, 2024
    Date of Patent: August 19, 2025
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Rolf Silbert, HongRan Peng, David Aaron Buse, David H. Combs
  • Publication number: 20250244352
    Abstract: After disposable pipette tips are used by an automated pipettor, they are released by the pipettor and fall into a waste container. When the waste container is removed to be emptied, the pipette tips are temporarily sequestered in a pipette tip holding station so that the automated pipettor may operate uninterrupted. After the waste container is replaced, the sequestered pipette tips are released by the holding station into the waste container.
    Type: Application
    Filed: March 13, 2025
    Publication date: July 31, 2025
    Applicant: Gen-Probe Incorporated
    Inventors: David H. COMBS, Norbert D. HAGEN, Ayra BAKER, Joseph Reed ELLIS
  • Publication number: 20250235873
    Abstract: An apparatus includes vertically spaced holding shelves, each including first and second shelf portions separated by an open area. A carrier configured to hold consumables is longer than the open area so that ends of the carrier can be supported on the first and second shelf portions. A transporter includes a support chassis laterally spaced from the holding shelves, a lift platform for carrying the carrier and having a length that is less than the length of the open area, a scissors actuator connecting the lift platform to the support chassis and configured to translate the lift platform laterally between a first position aligned with the support chassis and a second position laterally displaced from the support chassis and aligned with the open area of one of the holding shelves, and a transport elevator coupled to the support chassis for moving the support chassis in a vertical direction between the plurality of holding shelves.
    Type: Application
    Filed: April 8, 2025
    Publication date: July 24, 2025
    Applicant: GEN-PROBE INCORPORATED
    Inventors: David A. BUSE, Jin CHEN, David H. COMBS, Julian GROELI, Norbert D. HAGEN, David OPALSKY
  • Publication number: 20250208158
    Abstract: After disposable pipette tips are used by an automated pipettor, they are released by the pipettor and fall into a waste container. When the waste container is removed to be emptied, the pipette tips are temporarily sequestered in a pipette tip holding station so that the automated pipettor may operate uninterrupted. After the waste container is replaced, the sequestered pipette tips are released by the holding station into the waste container.
    Type: Application
    Filed: March 13, 2025
    Publication date: June 26, 2025
    Applicant: Gen-Probe Incorporated
    Inventors: David H. COMBS, Norbert D. HAGEN, Ayra BAKER, Joseph Reed ELLIS
  • Publication number: 20250199026
    Abstract: After disposable pipette tips are used by an automated pipettor, they are released by the pipettor and fall into a waste container. When the waste container is removed to be emptied, the pipette tips are temporarily sequestered in a pipette tip holding station so that the automated pipettor may operate uninterrupted. After the waste container is replaced, the sequestered pipette tips are released by the holding station into the waste container.
    Type: Application
    Filed: March 7, 2025
    Publication date: June 19, 2025
    Applicant: Gen-Probe Incorporated
    Inventors: David H. COMBS, Norbert D. HAGEN, Ayra BAKER, Joseph Reed ELLIS
  • Publication number: 20250123300
    Abstract: A receptacle delivery system for an instrument of a plurality of instruments comprises a carriage supporting a puck. The carriage is configured to move with the puck from a first location to a second location within the instrument. The first location is a location where a receptacle supported by a carrier is positioned to be transferred to the puck supported by the carriage, and the second location being a location where the receptacle seated in the puck is positioned so that fluid from the receptacle can be drawn into a tip associated with a fluid extraction device of the instrument.
    Type: Application
    Filed: December 20, 2024
    Publication date: April 17, 2025
    Applicant: Gen-Probe Incorporated
    Inventors: Rolf SILBERT, HongRan PENG, David Aaron BUSE, David H. COMBS
  • Patent number: 12216135
    Abstract: A receptacle delivery system that includes a rail extending between first and second locations of an instrument and a carriage configured to move on the rail between the first and second locations of the instrument. The carriage includes a bracket having opposed first and second sidewalls and a base extending between the first and second sidewalls, where the carriage is configured to support a receptacle. The carriage further includes a pair of opposed support pads, where the pair of support pads are configured to (a) move toward a receptacle supported by the carriage as the carriage moves from the first location toward the second location, and (b) move away from a receptacle supported by the carriage as the carriage moves from the second location toward the first location. The carriage also includes a pair of meshed cam gears rotatably coupled to the first sidewall, where each cam gear is coupled to a different one of the support pads.
    Type: Grant
    Filed: October 18, 2023
    Date of Patent: February 4, 2025
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Rolf Silbert, HongRan Peng, David Aaron Buse, David H. Combs
  • Patent number: 12210031
    Abstract: A receptacle-supporting puck includes spring-biased fingers arranged about a vertical axis, each finger having a contact surface to contact a receptacle seated in the puck. A supporting disc of the puck includes a disc sidewall projecting from a base and defining a pocket for seating a receptacle, first cavities in the base extending toward the vertical axis, and a puck passageway extending through opposed portions of the disc sidewall transversely to and offset from the vertical axis. Each finger is rotatably coupled to the supporting disc at a corresponding first cavity. A synchronization disc is positioned in the pocket, and each of the fingers is coupled to the synchronization disc such that the contact surfaces of the fingers move synchronously toward and away from the vertical axis. A retaining ring couples the fingers, the supporting disc, and the synchronization disc together.
    Type: Grant
    Filed: October 18, 2023
    Date of Patent: January 28, 2025
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Rolf Silbert, HongRan Peng, David Aaron Buse, David H. Combs
  • Patent number: 12210030
    Abstract: A method of delivering a receptacle to an instrument includes the steps of supporting a receptacle containing a fluid on a carrier, transporting the carrier supporting the receptacle on a conveyor extending adjacent to each of a plurality of instruments, transferring the receptacle from the carrier to a puck supported on a carriage when the carriage is positioned at a first location, moving the carriage with the receptacle seated in the puck from the first location to a second location within an instrument of the plurality of instruments, and drawing at least a portion of the fluid from the receptacle seated in the puck into a tip associated with a fluid extraction device of the instrument when the carriage is positioned at the second location.
    Type: Grant
    Filed: January 31, 2024
    Date of Patent: January 28, 2025
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Rolf Silbert, HongRan Peng, David Aaron Buse, David H. Combs
  • Patent number: 12210028
    Abstract: A receptacle delivery system includes a carriage configured to move from a first to a second location of an instrument. The carriage may be configured to removably support a receptacle and may include a receptacle clamping mechanism. The receptacle mechanism may be configured to apply a clamping force to the receptacle as the carriage moves from the first to the second location and release the clamping force as the carriage moves from the second to the first location.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: January 28, 2025
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Rolf Silbert, HongRan Peng, David Aaron Buse, David H. Combs
  • Publication number: 20240310399
    Abstract: Providing a fluid to an instrument comprises supporting a sample receptacle on a first carrier, transporting the first carrier on a conveyor adjacent a plurality of modules including at least one instrument, stopping the first carrier at the instrument, transporting the sample receptacle to a pick-up position of the instrument, transporting the sample receptacle from the pick-up position to a pipetting station within the instrument, aspirating fluid within the sample receptacle and transferring the aspirated fluid to a reaction receptacle, after aspirating fluid from the sample receptacle, transporting the sample receptacle to the pick-up position, transporting the sample receptacle from the pick-up position to a second carrier the conveyor, in the instrument, performing an assay to determine the presence or absence of an analyte in the aspirated fluid, and transporting the second carrier on the conveyor to one or more of the plurality of modules other than the analytical instrument.
    Type: Application
    Filed: May 7, 2024
    Publication date: September 19, 2024
    Applicant: Gen-Probe Incorporated
    Inventors: Rolf SILBERT, HongRan PENG, David Aaron BUSE, David H. COMBS
  • Publication number: 20240302400
    Abstract: Delivering a receptacle to an instrument comprises supporting a receptacle in a carriage when the carriage is positioned at a first location of the instrument, activating a sensing system coupled to the carriage to confirm that the receptacle is supported by the carriage, moving the carriage, and the receptacle supported therein, to a second location of the instrument, applying a clamping force to the receptacle as the carriage moves from the first location to the second location, at the second location, extracting at least a portion of a fluid contained in the receptacle using a fluid extraction device of the instrument, moving the carriage, and the receptacle supported therein, from the second location to the first location, and releasing the clamping force from the receptacle as the carriage moves from the second location to the first location.
    Type: Application
    Filed: May 7, 2024
    Publication date: September 12, 2024
    Applicant: Gen-Probe Incorporated
    Inventors: Rolf SILBERT, HongRan PENG, David Aaron BUSE, David H. COMBS
  • Publication number: 20240287981
    Abstract: A liquid container system having a liquid container, where the liquid container includes (i) an intermediate top wall, (ii) a liquid inlet tower extending above the intermediate top wall, (iii) a liquid inlet fluidly connected to the liquid inlet tower at a position above the intermediate top wall and through which the liquid container receives liquid from a liquid source, and (iv) a vacuum tower extending above the intermediate top wall and to which a pressure differential source can be fluidly connected at a position above the intermediate top wall to draw liquid into the liquid container through the liquid inlet.
    Type: Application
    Filed: May 3, 2024
    Publication date: August 29, 2024
    Inventors: David H. COMBS, Ayra A. BAKER, Norbert D. HAGEN, David A. BUSE
  • Publication number: 20240280096
    Abstract: A liquid container system including a transfer container for receiving liquid transferred to the transfer container by a liquid transfer pump, where the transfer container includes (i) a main body, (ii) a connector shelf extending laterally from the main body and including a horizontal portion and defining a bottom wall, and (iii) a liquid transfer connector fitting extending downwardly from the bottom wall of the horizontal portion of the connector shelf and configured for fluidly connecting the transfer container to the liquid transfer pump.
    Type: Application
    Filed: May 3, 2024
    Publication date: August 22, 2024
    Inventors: David H. COMBS, Ayra A. BAKER, Norbert D. HAGEN, David A. BUSE
  • Publication number: 20240201213
    Abstract: A receptacle delivery system for an instrument includes a carriage, a puck supported by the carriage, and a first shelf. The carriage is configured to move from a first location of the instrument to a second location of the instrument. The puck is configured to removably support a receptacle such that a longitudinal axis of the receptacle is substantially coincident with a vertical axis of the puck. The first shelf is positioned at the second location of the instrument and comprises (a) a base extending substantially transverse to the vertical axis of the puck and (b) a first opening defined by the base. When the carriage is positioned at the second location, the longitudinal axis of a receptacle seated in the puck extends through the first opening.
    Type: Application
    Filed: March 1, 2024
    Publication date: June 20, 2024
    Applicant: Gen-Probe Incorporated
    Inventors: Rolf SILBERT, HongRan PENG, David Aaron BUSE, David H. COMBS