Abstract: The present disclosure provides mutant vaccinia virus strains that can selectively replicate in tumor cells. The present disclosure also provides use of the mutant vaccinia virus strains for preventing and treating tumors.

Abstract: The disclosure provides mutant ribonucleotide reductase strains of poxviruses including for example vaccinia viruses. The disclosure also provides methods and for the use of these mutant ribonucleotide reductase strains of vaccinia viruses in oncolytic virotherapy. Also provided in the disclosure are vector constructs for generating mutant ribonucleotide reductase strains of poxviruses including for example vaccinia viruses. The disclosure also provides poxviruses comprising a functionally inactivated R2 gene.

Abstract: The present disclosure provides mutant vaccinia virus strains that can selectively replicate in tumor cells. The present disclosure also provides use of the mutant vaccinia virus strains for preventing and treating tumors.

Abstract: Embodiments of the present invention provide a system, method, and computer program product for updating software on an embedded computer device. According to one aspect of the present invention, a concurrent embedded application update is performed in which selected state information for one or both of an embedded virtual machine and a plurality of applets on an embedded computer device is securely exported to a host computer device. After software updates have been installed, the selected state information can be restored on the embedded computer device from which it was exported and/or it can be migrated to a second embedded computer device.

Abstract: The disclosure provides mutant ribonucleotide reductase strains of poxviruses including for example vaccinia viruses. The disclosure also provides methods and for the use of these mutant ribonucleotide reductase strains of vaccinia viruses in oncolytic virotherapy.

Abstract: The disclosure provides mutant ribonucleotide reductase strains of poxviruses including for example vaccinia viruses. The disclosure also provides methods and for the use of these mutant ribonucleotide reductase strains of vaccinia viruses in oncolytic virotherapy.

Abstract: Embodiments of the present invention provide a system, method, and computer program product for updating software on an embedded computer device. According to one aspect of the present invention, a concurrent embedded application update is performed in which selected state information for one or both of an embedded virtual machine and a plurality of applets on an embedded computer device is securely exported to a host computer device. After software updates have been installed, the selected state information can be restored on the embedded computer device from which it was exported and/or it can be migrated to a second embedded computer device.

Abstract: The disclosure provides mutant ribonucleotide reductase strains of poxviruses including for example vaccinia viruses. The disclosure also provides methods and for the use of these mutant ribonucleotide reductase strains of vaccinia viruses in oncolytic virotherapy.

Abstract: The present invention provides a method to directionally clone any linear template DNA molecule into any linearized vector. The vector ends may be generated from any restriction enzyme cleavage. The method does not require a ligation step nor the use of carefully controlled conditions as is required with methods involving specific exonucleases alone. It has been determined that specific DNA polymerases are able to efficiently join one or more linear DNA molecules sharing ends with appropriate complementation.

Abstract: A radio apparatus (400) comprises first and second antennas (42,44), a first transceiver (40) having a first transmitter (60) and a first receiver (61), a second receiver (62), a switching means (45, 46) arranged to provide selectable first and second states, and a control means (50) adapted to select between the first and second states for simultaneous transmission by the first transmitter (60) and reception by the second receiver (62). The switching means (45, 46) enables the first transmitter (60) to be coupled to either one of the first and second antennas (42, 44) and simultaneously the second receiver (62) to be coupled to the other of the antennas (42, 44), but prohibits coupling of both the first transmitter (60) and the second receiver (62) to a common antenna (42 or 44).

Abstract: A wireless local area network (LAN) comprises an access point which transmits a beacon signal at 0 dBm. The detection threshold of the mobile unit is ?65 dBm and thus the mobile unit is detected when located within 10 meters of the access point.

Abstract: In a radio communication system comprising a plurality of stations (100a,100b,100c) operating in a peer-to-peer mode, each station stores information relating to the transmission parameters of other stations. Such information may include the frequency offset and received signal strength of signals from the other stations. One station acts as central controller and allocates time slots for transmission from a first station (100a) to a second station (100b). Before the first station (100a) receives a signal from the second station (100b) it makes initial adjustments to its receiver circuitry depending on the stored information about previous signals received from that station (100b). This simplifies the task of adjusting the receiver circuitry during the preamble of the signal transmitted by the second station (100b).

Abstract: An improved source-level debugger for object-oriented application programs which may include linked native language dynamic load libraries. The debugger is compatible with the Java Platform Debugger Architecture (“JPDA”), and provides new capabilities such as patching of Java variables and reading and writing strings from and to the application under test and being run by a local or remote Java Virtual Machine.

Abstract: A method of selecting a combination of transmit antennas (TA1 to TA4) and receive antennas (RA1 to RA4) in a MIMO antenna system to give the best isolation from adjacent parallel signal streams comprises transmitting a first signal from one of the transmit antennas and measuring a quality metric, for example signal strength of the received signal at each of the receive antennas. The process is repeated using signals transmitted in turn by each the remaining transmit antennas. A channel matrix is compiled of the transmit antennas versus the receive antennas and a selection is made of a combination of transmit and receive antennas receiving acceptably a first signal and unacceptably a second signal and vice versa. The selected combination is used to send and receive MIMO signals. Switches (SW1, SW2) are provided for coupling the selected antennas to the respective transmitters (TX1, TX2) and receivers (RX1, RX2).

Abstract: An antenna diversity system includes at least two antennas. Each antenna may be connected via a common connection point to a receiver by a respective switch which presents a low impedance connection between the antenna and receiver in the on state and a substantially reactive load to the antenna in the off state. Selection of appropriate impedances for the off state load enables the antennas to function as an array with a variety of beam patterns depending on the state of the switches. Cycling through a sequence of switch states steers the antenna beam providing improved resistance to fading and multipath effects. Alternatively, the antennas may be connected to a hybrid coupler, which enables two beam patterns to be available simultaneously for signal quality measurement and comparison.

Abstract: The present invention relates to methods and kits for modifying viral genomes. The method involves introducing into a host cell containing a helper virus, two or more fragments of a first viral genome, the fragments having ends that are capable of being joined together comprising as little as basepair of overlapping sequence. The helper virus is able to facilitate recombination and reactivation of the DNA fragments into active infectious virions.

Abstract: The present invention provides a method to directionally clone any linear template DNA molecule into any linearized vector. The vector ends may be generated from any restriction enzyme cleavage. The method does not require a ligation step nor the use of carefully controlled conditions as is required with methods involving specific exonucleases alone. It has been determined that specific DNA polymerases are able to efficiently join one or more linear DNA molecules sharing ends with appropriate complementation.

Abstract: A wireless local area network system comprises an ATM switch (10) coupled to an access point (12) having a transceiver and a plurality of mobile terminals (14) each having a transceiver. The transceivers operate in accordance with an Orthogonal Frequency-Division Multiplexing (OFDM) transmission scheme having a plurality of channels. In response to the access point (12) polling the mobile terminals (14) enquiring if they want a time slot in the next down-link frame, those mobile terminals wanting a time slot transmit an E-burst on selected ones of the plurality of channels whose phases are selected to minimise the transmitted peak to mean envelope power. Optionally the E-burst can be modulated to provide a limited amount of signalling information.

Abstract: A method of selecting a combination of transmit antennas (TA1 to TA4) and receive antennas (RA1 to RA4) in a MIMO antenna system to give the best isolation from adjacent parallel signal streams comprises transmitting a first signal from one of the transmit antennas and measuring a quality metric, for example signal strength, of the received signal at each of the receive antennas. The process is repeated using signals transmitted in turn by each the remaining transmit antennas. A channel matrix is compiled of the transmit antennas versus the receive antennas and a selection is made of a combination of transmit and receive antennas receiving acceptably a first signal and unacceptably a second signal and vice versa. The selected combination is used to send and receive MIMO signals.

Abstract: A transmitter for transmitting orthogonal signals comprises a power amplifier (112) having a transfer characteristic in which gain is substantially independent of applied bias voltage. A digital signal for transmission is monitored by a level detector (116) which determines the peak output power required from the power amplifier (112). This information is used by a power supply controller (122) to control the DC bias voltage applied to the power amplifier (112) so that the applied voltage is reduced for low signal levels and increased for high signal levels, thereby increasing the efficiency with which supplied power is converted to radiated power. The applied voltage may be changed for each output symbol, or may be continuously adapted to track the peak envelope power. This method of controlling the amplifier (112) may be used in conjunction with coding schemes for reducing the peak to mean power ratio.