Patents by Inventor David H. Ingbar

David H. Ingbar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING PULMONARY EDEMA OR LUNG INFLAMMATION
    Publication number: 20240350406
    Abstract: A pharmaceutical composition for administering directly to the pulmonary tract of a subject includes a salt of triiodothyronine and a pharmaceutically acceptable buffer, adjusted to a pH of 5.5-8.5. The composition can be administered prophylactically or therapeutically to a subject to treat lung inflammation or pulmonary edema.
    Type: Application
    Filed: December 14, 2023
    Publication date: October 24, 2024
    Inventors: David H. Ingbar, Timothy P. Rich, Robert J. Schumacher, Jianxun Lei, Maneesh Bhargava
  • Compositions and methods for treating pulmonary edema or lung inflammation
    Patent number: 11883528
    Abstract: A pharmaceutical composition for administering directly to the pulmonary tract of a subject includes a salt of triiodothyronine and a pharmaceutically acceptable buffer, adjusted to a pH of 5.5-8.5. The composition can be administered prophylactically or therapeutically to a subject to treat lung inflammation or pulmonary edema.
    Type: Grant
    Filed: August 23, 2022
    Date of Patent: January 30, 2024
    Assignee: Regents of the University of Minnesota
    Inventors: David H. Ingbar, Timothy P. Rich, Robert J. Schumacher, Jianxun Lei, Maneesh Bhargava
  • COMPOSITIONS AND METHODS FOR TREATING PULMONARY EDEMA OR LUNG INFLAMMATION
    Publication number: 20230147865
    Abstract: A pharmaceutical composition for administering directly to the pulmonary tract of a subject includes a salt of triiodothyronine and a pharmaceutically acceptable buffer, adjusted to a pH of 5.5-8.5. The composition can be administered prophylactically or therapeutically to a subject to treat lung inflammation or pulmonary edema.
    Type: Application
    Filed: March 26, 2021
    Publication date: May 11, 2023
    Inventors: David H. Ingbar, Timothy P. Rich, Robert J. Schumacher
  • COMPOSITIONS AND METHODS FOR TREATING PULMONARY EDEMA OR LUNG INFLAMMATION
    Publication number: 20230050861
    Abstract: A pharmaceutical composition for administering directly to the pulmonary tract of a subject includes a salt of triiodothyronine and a pharmaceutically acceptable buffer, adjusted to a pH of 5.5-8.5. The composition can be administered prophylactically or therapeutically to a subject to treat lung inflammation or pulmonary edema.
    Type: Application
    Filed: August 23, 2022
    Publication date: February 16, 2023
    Inventors: David H. Ingbar, Timothy P. Rich, Robert J. Schumacher, Jianxun Lei, Maneesh Bhargava
  • Compositions and methods for treating pulmonary edema or lung inflammation
    Patent number: 11458094
    Abstract: A pharmaceutical composition for administering directly to the pulmonary tract of a subject includes a salt of triiodothyronine and a pharmaceutically acceptable buffer, adjusted to pH of 5.5-8.5. The composition can be administered prophylactically or therapeutically to a subject to treat lung inflammation or pulmonary edema.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: October 4, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: David H. Ingbar, Timothy P. Rich, Robert J. Schumacher, Jianxun Lei, Maneesh Bhargava
  • COMPOSITIONS AND METHODS FOR TREATING PULMONARY EDEMA OR LUNG INFLAMMATION
    Publication number: 20220265775
    Abstract: A pharmaceutical composition for administering directly to the pulmonary tract of a subject includes an active agent effective to increase T3 concentration in the lung of the subject and a pharmaceutically acceptable buffer, adjusted to a pH of 5.5-8.5. The active agent can include a deiodinase inhibitor, a thyroid hormone mimetic, or a thyroid hormone analog. In some embodiments, the composition can include an additional active agent. The compositions can be used to treat lung inflammation. In some embodiments, the compositions also can be used to treat pulmonary edema. The compositions can be administered to a subject by direct instillation to the pulmonary tract or inhalation directly to the pulmonary tract.
    Type: Application
    Filed: July 29, 2020
    Publication date: August 25, 2022
    Inventors: Timothy P. Rich, David H. Ingbar
  • COMPOSITIONS AND METHODS FOR TREATING PULMONARY EDEMA OR LUNG INFLAMMATION
    Publication number: 20210113462
    Abstract: A pharmaceutical composition for administering directly to the pulmonary tract of a subject includes a salt of triiodothyronine and a pharmaceutically acceptable buffer, adjusted to pH of 5.5-8.5. The composition can be administered prophylactically or therapeutically to a subject to treat lung inflammation or pulmonary edema.
    Type: Application
    Filed: January 31, 2019
    Publication date: April 22, 2021
    Inventors: David H. Ingbar, Timothy P. Rich, Robert J. Schumacher, Jianxun Lei, Maneesh Bhargava