Patents by Inventor David H. Katz

David H. Katz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunochemical conjugates: method and composition
    Patent number: 4276206
    Abstract: Techniques for preparing stable conjugates of protein-D-GL which can then be isolated in pure form are disclosed, using hen egg ovalbumin (OVA) as a prototype protein, and conjugation and purification methods are described which involve (1) application of a coupling method employing m-maleimidobenzoyl-N-hydroxysuccinimide ester (MBS) as the coupling reagent, and (2) introduction of biotin moieties into D-GL molecules to allow application of avidinbiotin system for affinity chromatographic purification of conjugates. These methods are applicable to the preparation of D-GL conjugates of insulin and Ragweed Antigen E and are of general applicability.
    Type: Grant
    Filed: February 11, 1980
    Date of Patent: June 30, 1981
    Assignee: Scripps Clinic & Research Foundation
    Inventor: David H. Katz
  • Immunochemical conjugates: method and composition
    Patent number: 4253995
    Abstract: Techniques for preparing stable conjugates of protein-D-GL which can then be isolated in pure form are disclosed, using hen egg ovalbumin (OVA) as a prototype protein, and conjugation and purification methods are described which involve (1) application of a coupling method employing m-maleimidobenzoyl-N-hydroxysuccinimide ester (MBS) as the coupling reagent, and (2) introduction of biotin moieties into D-GL molecules to allow application of avidinbiotin system for affinity chromatographic purification of conjugates. These methods are applicable to the preparation of D-GL conjugates of insulin and Ragweed Antigen E and are of general applicability.
    Type: Grant
    Filed: February 11, 1980
    Date of Patent: March 3, 1981
    Assignee: Scripps Clinic and Research Foundation
    Inventor: David H. Katz
  • Immunochemical conjugates: method and composition
    Patent number: 4253996
    Abstract: Techniques for preparing stable conjugates of protein-D-GL which can then be isolated in pure form are disclosed, using hen egg ovalbumin (OVA) as a prototype protein, and conjugation and purification methods are described which involve (1) application of a coupling method employing m-maleimidobenzoyl-N-hydroxysuccinimide ester (MBS) as the coupling reagent, and (2) introduction of biotin moieties into D-GL molecules to allow application of avidinbiotin system for affinity chromatographic purification of conjugates. These methods are applicable to the preparation of D-GL conjugates of insulin and Ragweed Antigen E and are of general applicability.
    Type: Grant
    Filed: February 13, 1980
    Date of Patent: March 3, 1981
    Assignee: Scripps Clinic and Research Foundation
    Inventor: David H. Katz
  • Induction of immunological tolerance
    Patent number: 4222907
    Abstract: Immunosuppressive agents which are conjugates of an antigen linked to a D glutamic acid:D-lysine copolymer are disclosed. Also disclosed are methods of preparing the conjugates and therapeutic methods for inducing immunological tolerance to antigens.
    Type: Grant
    Filed: September 25, 1978
    Date of Patent: September 16, 1980
    Assignee: Scripps Clinic & Research Foundation
    Inventor: David H. Katz
  • Immunochemical conjugates: method and composition
    Patent number: 4220565
    Abstract: Techniques for preparing stable conjugates of protein-D-GL which can then be isolated in pure form are disclosed, using hen egg ovalbumin (OVA) as a prototype protein, and conjugation and purification methods are described which involve (1) application of a coupling method employing m-maleimidobenzoyl-N-hydroxysuccinimide ester (MBS) as the coupling reagent, and (2) introduction of biotin moieties into D-GL molecules to allow application of avidinbiotin system for affinity chromatographic purification of conjugates. These methods are applicable to the preparation of D-GL conjugates of insulin and Ragweed Antigen E and are of general applicability.
    Type: Grant
    Filed: January 18, 1979
    Date of Patent: September 2, 1980
    Assignee: Scripps Clinic & Research Foundation
    Inventor: David H. Katz
  • Induction of immunological tolerance
    Patent number: 4191668
    Abstract: Immunosuppressive agents which are conjugates of an antigen linked to a D-glutamic acid:D-lysine copolymer are disclosed. Also disclosed are methods of preparing the conjugates and therapeutic methods for inducing immunological tolerance to antigens.
    Type: Grant
    Filed: February 3, 1977
    Date of Patent: March 4, 1980
    Assignee: Scripps Clinic and Research Foundation
    Inventor: David H. Katz