Patents by Inventor David H. Ledbetter

David H. Ledbetter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for the diagnosis of fragile X syndrome
    Patent number: 6143504
    Abstract: The present invention relates generally to the field of diagnostics. More particularly, it concerns the use of methylation-specific PCR in order to identify those males having Fragile X syndrome. The present invention provides a method in which amplification specific for the methylated FMR1 sequence is observed in all individuals with a full mutation, while all normal and premutation individuals show only amplification specific for the unmethylated sequence, thus allowing affected and unaffected males to be distinguished. A full mutation in the presence of mosaicism also may detectable by this method. Thus, methylation-specific PCR is demonstrated as a rapid and reliable tool for the diagnosis of fragile X.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: November 7, 2000
    Assignee: Arch Development Corporation
    Inventors: Soma Das, David H. Ledbetter