Abstract: Electrostatic aerosol in vitro exposure systems and methods are disclosed and can be used for collecting and depositing particulate matter onto tissue without pre-concentration, and without any intermediate collection steps such as use in water or on a filter. The system can include an inlet configured to receive air containing particulate matter, a receptacle configured to hold one or more tissue samples, a porous membrane providing support for an air-liquid interface of the tissue sample, and an electrostatic precipitation area. Particulate matter contained in the air received at the inlet can be electrically charged in the electrostatic precipitation area and flowed over the tissue sample, where it can be collected and measured.

Abstract: A breath-actuated dry powder medicament inhalator device having a housing and a conduit mounted within the housing defining an air passageway therethrough having an aperture in the sidewall thereof. A blister-type strip of sealed containers arranged in a matrix of rows and columns wherein the columns extend generally diagonally to the longitudinal axis of the strip is secured in a two-piece cage adapted for being rotatably mounted around the conduit of the inhalator device. Advancement means are provided for rotatably moving the two-piece cage and blister strip contained thereby in a generally helical pathway relative to the conduit so as to successively advance each of the sealed containers of the blister strip into registration with the conduit aperture.

Abstract: An apparatus for administering an aerosol of a solid particulate medicament (e.g., amiloride) to the lungs of a patient is disclosed. The apparatus comprises a solid particulate medicament aerosol generator and an impactor assembly for removing large particles of medicament from the aerosol produced by the aerosol generator. The impactor assembly comprises an enclosed chamber having an inlet opening and an outlet opening formed on opposite sides thereof. The aerosol generator is connected to the inlet opening. A first impactor plate is positioned in the chamber, with the first impactor plate adjacent the inlet opening. The first impactor plate has an uninterrupted primary impaction surface formed thereon, with the primary impaction surface substantially axially aligned with the inlet opening and having a diameter not less than the inlet opening. The first impactor plate has at least one exhaust opening formed therein in fluid communication with the outlet opening.