Patents by Inventor David H. Lloyd
David H. Lloyd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6048974Abstract: Compounds referred to herein as oligonucleotide clamps are provided that stably bind to target polynucleotides in a sequence-specific manner. The oligonucleotide clamps comprise one or more oligonucleotide moieties capable of specifically binding to a target polynucleotide and one or more pairs of binding moieties covalently linked to the oligonudeotide moieties. In accordance with the invention, upon annealing of the oligonucleotide moieties to the target polynucleotide, the binding moieties of a pair are brought into juxtaposition so that they form a stable covalent or non-covalent inkage or complex. The interaction of the binding moieties of the one or more pairs effectively clamps the specifically annealed oligonucleotide moieties to the target polynucleotide.Type: GrantFiled: April 30, 1998Date of Patent: April 11, 2000Assignee: Lynx Therapeutics, Inc.Inventors: Sergei M. Gryaznov, David H. Lloyd
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Patent number: 6013445Abstract: The invention provides a method of nucleic acid sequence analysis based on the ligation of one or more sets of encoded adaptors to the terminus of a target polynucleotide. Encoded adaptors whose protruding strands form perfectly matched duplexes with the complementary protruding strands of the target polynucleotide are ligated, and the identity of the nucleotides in the protruding strands is determined by an oligonucleotide tag carried by the encoded adaptor. Such determination, or "decoding" is carried out by specifically hybridizing a labeled tag complement to its corresponding tag on the ligated adaptor.Type: GrantFiled: October 7, 1997Date of Patent: January 11, 2000Assignee: Lynx Therapeutics, Inc.Inventors: Glenn Albrecht, Sydney Brenner, Robert B. DuBridge, David H. Lloyd, Michael C. Pallas
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Patent number: 5817795Abstract: Compounds referred to herein as oligonucleotide clamps are provided that stably bind to target polynucleotides in a sequence-specific manner. The oligonucleotide clamps comprise one or more oligonucleotide moieties capable of specifically binding to a target polynucleotide and one or more pairs of binding moieties covalently linked to the oligonucleotide moieties. In accordance with the invention, upon annealing of the oligonucleotide moieties to the target polynucleotide, the binding moieties of a pair are brought into juxtaposition so that they form a stable covalent or non-covalent linkage or complex. The interaction of the binding moieties of the one or more pairs effectively clamps the specifically annealed oligonucleotide moieties to the target polynucleotide.Type: GrantFiled: September 17, 1996Date of Patent: October 6, 1998Assignee: Lynx Therapeutics, Inc.Inventors: Sergei M. Gryaznov, David H. Lloyd
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Patent number: 5741643Abstract: Compounds referred to herein as oligonucleotide clamps are provided that stably bind to target polynucleotides in a sequence-specific manner. The oligonucleotide clamps comprise one or more oligonucleotide moieties capable of specifically binding to a target polynucleotide and one or more pairs of binding moieties covalently linked to the oligonucleotide moieties. In accordance with the invention, upon annealing of the oligonucleotide moieties to the target polynucleotide, the binding moieties of a pair are brought into juxtaposition so that they form a stable covalent or non-covalent linkage or complex. The interaction of the binding moieties of the one or more pairs effectively clamps the specifically annealed oligonucleotide moieties to the target polynucleotide.Type: GrantFiled: June 5, 1995Date of Patent: April 21, 1998Assignee: Lynx Therapeutics, Inc.Inventors: Sergei M. Gryaznov, David H. Lloyd
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Patent number: 5473060Abstract: Compounds referred to herein as oligonucleotide clamps are provided that stably bind to target polynucleotides in a sequence-specific manner. The oligonucleotide clamps comprise one or more oligonucleotide moieties capable of specifically binding to a target polynucleotide and one or more pairs of binding moieties covalently linked to the oligonucleotide moieties. In accordance with the invention, upon annealing of the oligonucleotide moieties to the target polynucleotide, the binding moieties of a pair are brought into juxtaposition so that they form a stable covalent or non-covalent linkage or complex. The interaction of the binding moieties of the one or more pairs effectively clamps the specifically annealed oligonucleotide moieties to the target polynucleotide.Type: GrantFiled: July 2, 1993Date of Patent: December 5, 1995Assignee: Lynx Therapeutics, Inc.Inventors: Sergei M. Gryaznov, David H. Lloyd
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Patent number: 5462748Abstract: A cartridge containing a dry polymer composition carrying trapped biopolymer subunits for use in synthesis of biopolymer chains provides a discrete unit for stepwise supply of subunits, such as protected amino acids, in an automated apparatus for biopolymer synthesis. The composition is swellable in organic solvent to release and supply the subunits to a growing biopolymer chain immobilized on a polymer support. An automated synthesizer uses the cartridges for sequential subunit supply and monitors conductivity of deprotection reagents to control cycling and timing of steps.Type: GrantFiled: January 14, 1994Date of Patent: October 31, 1995Assignee: Applied Biosystems, Inc.Inventors: David H. Lloyd, Robert J. DeFranco, Charles S. Ladd
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Patent number: 5298259Abstract: A polymer composition having a biopolymer subunit entrapped in a swellable polymer matrix is described. The composition may be supplied in a disposable cartridge, for use in delivering a solution of the subunit in an automated biopolymer synthesis operation.Type: GrantFiled: November 5, 1991Date of Patent: March 29, 1994Assignee: Applied Biosystems, Inc.Inventors: David H. Lloyd, Robert J. DeFranco
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Patent number: 4989812Abstract: Automatically deployable support means for a body requiring, in use, to stand in an upright position on a surface, for example a land surface or the sea bed has a plurality of legs pivoted to the body so as to be movable from a stowed position to a support position in which they extend generally outwards and downwards from the body, the deployment means for effecting such movement including an axially movable cam housed in the body and a cam follower formed on each leg.Type: GrantFiled: August 23, 1989Date of Patent: February 5, 1991Assignee: British Aerospace Public Limited CompanyInventor: David H. Lloyd
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Patent number: RE43097Abstract: The invention provides a method of nucleic acid sequence analysis based on the ligation of one or more sets of encoded adaptors to the terminus of a target polynucleotide. Encoded adaptors whose protruding strands form perfectly matched duplexes with the complementary protruding strands of the target polynucleotide are ligated, and the identity of the nucleotides in the protruding strands is determined by an oligonucleotide tag carried by the encoded adaptor. Such determination, or “decoding” is carried out by specifically hybridizing a labeled tag complement to its corresponding tag on the ligated adaptor.Type: GrantFiled: May 18, 2010Date of Patent: January 10, 2012Assignee: Illumina, Inc.Inventors: Glenn Albrecht, Sydney Brenner, Robert B. DuBridge, David H. Lloyd, Michael C. Pallas