Patents by Inventor David H. Rein
David H. Rein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090269389Abstract: ARPE-19 cells were evaluated as a platform cell line for encapsulated and unencapsulated cell-based delivery technology. ARPE-19 cells were found to be hardy (the cell line is viable under stringent conditions, such as in central nervous system or intra-ocular environment); can be genetically modified to secrete the protein of choice; have a long life span; are of human origin; have good in vivo device viability; deliver efficacious quantity of growth factor; trigger no or low level host immune reaction, and are non-tumorigenic.Type: ApplicationFiled: July 7, 2009Publication date: October 29, 2009Applicant: NEUROTECH USA, INC.Inventors: Weng Tao, David H. Rein, Brenda J. Dean, Paul F. Stabila, Moses B.I. Goddard
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Publication number: 20090269319Abstract: ARPE-19 cells were evaluated as a platform cell line for encapsulated and unencapsulated cell-based delivery technology. ARPE-19 cells were found to be hardy (the cell line is viable under stringent conditions, such as in central nervous system or intra-ocular environment); can be genetically modified to secrete the protein of choice; have a long life span; are of human origin; have good in vivo device viability; deliver efficacious quantity of growth factor; trigger no or low level host immune reaction, and are non-tumorigenic.Type: ApplicationFiled: July 8, 2009Publication date: October 29, 2009Applicant: NEUROTECH USA, INC.Inventors: Weng Tao, David H. Rein, Brenda J. Dean, Paul F. Stabila, Moses B.I. Goddard
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Patent number: 7115257Abstract: ARPE-19 cells were evaluated as a platform cell line for encapsulated and unencapsulated cell-based delivery technology. ARPE-19 cells were found to be hardy (the cell line is viable under stringent conditions, such as in central nervous system or intra-ocular environment); can be genetically modified to secrete the protein of choice; have a long life span; are of human origin; have good in vivo device viability; deliver efficacious quantity of growth factor; trigger no or low level host immune reaction, and are non-tumorigenic.Type: GrantFiled: April 6, 2000Date of Patent: October 3, 2006Assignee: Neurotech S.A.Inventors: Weng Tao, David H. Rein, Brenda J. Dean, Paul F. Stabila, Moses B. I. Goddard
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Patent number: 6361771Abstract: ARPE-19 cells were evaluated as a platform cell line for encapsulated and un-encapsulated cell-based delivery technology. ARPE-19 cells were found to be hardy (the cell line is viable under stringent conditions, such as in central nervous system or intra-ocular environment); can be genetically modified to secrete the protein of choice; has a long life span; is of human origin; has good in vivo device viability; delivers efficacious quantity of growth factor; triggers no or low level host immune reaction, and is non-tumorigenic.Type: GrantFiled: April 5, 2000Date of Patent: March 26, 2002Assignee: Neurotech S.A.Inventors: Weng Tao, David H. Rein, Brenda J. Dean, Paul F. Stabila, Moses B.I. Goddard
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Patent number: 6123700Abstract: A sealed, implantable, encapsulation device (20) for diffusing a biologically active product or function to an individual which includes a substantially non-porous fitting (32) including an inner surface (33) defining an access port (34). A permselective, porous, membrane (21), having an interior surface (22), cooperates with the fitting inner surface (33) to form a storage cavity (23) therebetween. The membrane interior surface (22) is in substantially cell-tight dry sealing engagement with fitting (32) to seal cavity (23). Living cells (24) are disposed in the cavity (23) which are capable of secreting the biologically active product to an individual. The membrane (21) is of a material capable of permitting the passage of substances between the individual and cells required to provide the biological product or function. A plug member (35) is positioned in the access port (34) and seated in cell-tight sealing engagement with the fitting inner surface (33).Type: GrantFiled: January 30, 1998Date of Patent: September 26, 2000Assignee: Brown University Research FoundationInventors: John F. Mills, Edward J. Doherty, Tyrone F. Hazlett, Keith E. Dionne, Nicholas F. Warner, Brian M. Cain, David H. Rein
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Method and apparatus for sealing implantable, membrane encapsulation devices containing living cells
Patent number: 5932460Abstract: A sealed, implantable, encapsulation device (20) for diffusing a biologically active product or function to an individual which includes a substantially non-porous fitting (32) including an inner surface (33) defining an access port (34). A permselective, porous, membrane (21), having an interior surface (22), cooperates with the fitting inner surface (33) to form a storage cavity (23) therebetween. The membrane interior surface (22) is in substantially cell-tight dry sealing engagement with fitting (32) to seal cavity (23). Living cells (24) are disposed in the cavity (23) which are capable of secreting the biologically active product to an individual. The membrane (21) is of a material capable of permitting the passage of substances between the individual and cells required to provide the biological product or function. A plug member (35) is positioned in the access port (34) and seated in cell-tight sealing engagement with the fitting inner surface (33).Type: GrantFiled: June 6, 1995Date of Patent: August 3, 1999Assignee: Brown University Research FoundationInventors: John F. Mills, Edward J. Doherty, Tyrone F. Hazlett, Keith E. Dionne, Nicholas F. Warner, Brian M. Cain, David H. Rein -
Patent number: 5738673Abstract: A sealed, implantable, encapsulation device (20) for diffusing a biologically active product or function to an individual which includes a substantially non-porous fitting (32) including an inner surface (33) defining an access port (34). A permselective, porous, membrane (21), having an interior surface (22), cooperates with the fitting inner surface (33) to form a storage cavity (23) therebetween. The membrane interior surface (22) is in substantially cell-tight dry sealing engagement with fitting (32) to seal cavity (23). Living cells (24) are disposed in the cavity (23) which are capable of secreting the biologically active product to an individual. The membrane (21) is of a material capable of permitting the passage of substances between the individual and cells required to provide the biological product or function. A plug member (35) is positioned in the access port (34) and seated in cell-tight sealing engagement with the fitting inner surface (33).Type: GrantFiled: June 7, 1995Date of Patent: April 14, 1998Assignee: Brown University Research FoundationInventors: John F. Mills, Edward J. Doherty, Tyrone F. Hazlett, Keith E. Dionne, Nicholas F. Warner, Brian M. Cain, David H. Rein
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Patent number: 5713887Abstract: A sealed, implantable, encapsulation device (20) for diffusing a biologically active product or function to an individual which includes a substantially non-porous fitting (32) including an inner surface (33) defining an access port (34). A permselective, porous, membrane (21), having an interior surface (22), cooperates with the fitting inner surface (33) to form a storage cavity (23) therebetween. The membrane interior surface (22) is in substantially cell-tight dry sealing engagement with fitting (32) to seal cavity (23). Living cells (24) are disposed in the cavity (23) which are capable of secreting the biologically active product to an individual. The membrane (21) is of a material capable of permitting the passage of substances between the individual and cells required to provide the biological product or function. A plug member (35) is positioned in the access port (34) and seated in cell-tight sealing engagement with the fitting inner surface (33).Type: GrantFiled: June 6, 1995Date of Patent: February 3, 1998Assignee: Brown University Research FoundationInventors: John F. Mills, Edward J. Doherty, Tyrone F. Hazlett, Keith E. Dionne, Nicholas F. Warner, Brian M. Cain, David H. Rein
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Patent number: 5653687Abstract: A sealed, implantable, encapsulation device (20) for diffusing a biologically active product or function to an individual which includes a substantially non-porous fitting (32) including an inner surface (33) defining an access port (34). A permselective, porous, membrane (21), having an interior surface (22), cooperates with the fitting inner surface (33) to form a storage cavity (23) therebetween. The membrane interior surface (22) is in substantially cell-tight dry sealing engagement with fitting (32) to seal cavity (23). Living cells (24) are disposed in the cavity (23) which are capable of secreting the biologically active product to an individual. The membrane (21) is of a material capable of permitting the passage of substances between the individual and cells required to provide the biological product or function. A plug member (35) is positioned in the access port (34) and seated in cell-tight sealing engagement with the fitting inner surface (33).Type: GrantFiled: June 6, 1995Date of Patent: August 5, 1997Assignee: Brown University Research FoundationInventors: John F. Mills, Edward J. Doherty, Tyrone F. Hazlett, Keith E. Dionne, Nicholas F. Warner, Brian M. Cain, David H. Rein
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Patent number: 5653688Abstract: A sealed, implantable, encapsulation device (20) for diffusing a biologically active product or function to an individual which includes a substantially non-porous fitting (32) including an inner surface (33) defining an access port (34). A permselective, porous, membrane (21), having an interior surface (22), cooperates with the fitting inner surface (33) to form a storage cavity (23) therebetween. The membrane interior surface (22) is in substantially cell-tight dry sealing engagement with fitting (32) to seal cavity (23). Living cells (24) are disposed in the cavity (23) which are capable of secreting the biologically active product to an individual. The membrane (21) is of a material capable of permitting the passage of substances between the individual and cells required to provide the biological product or function. A plug member (35) is positioned in the access port (34) and seated in cell-tight sealing engagement with the fitting inner surface (33).Type: GrantFiled: June 6, 1995Date of Patent: August 5, 1997Assignee: Brown University Research FoundationInventors: John F. Mills, Edward J. Doherty, Tyrone F. Hazlett, Keith E. Dionne, Nicholas F. Warner, Brian M. Cain, David H. Rein