Abstract: Provided herein are compounds of the Formula (I): (I) and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein Rx, Ry, W, X, Y, Z, Ring A and (AA) have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: A content and traffic managing system operatively associated with and a computer implemented method of managing traffic of a mobile device exhibiting communication functionality. The mobile device is connectable to users and to content providers via communication links. The system tracks various parameters over time, and schedules communication, both in relation to predefined or projected content responsive of the following: users' content related behavior, users' communication behavior, users' external behavior, and parameters of communication links.

Abstract: International travel preparation systems are provided. Methods of offering services for sale over the internet are provided. Services may include travel preparation services. Travel preparation services may include travel and medical insurance, passport services and medical preparation services. Customized travel medical reports used by medical professionals and snippet reports used by consumers and retailers to educate travelers on the perils of international travel designed to protect consumers and generate sales opportunities for retailers who service those travelers are provided. Computer readable mediums having processor-executable instructions stored thereon which, when executed by at least one processor, cause the at least one processor to perform a method of offering services for sale over the internet are provided.

Abstract: A bracket for a printer includes a frame with first and second side supports. A print area is defined in part by the side supports. A plurality of web support members laterally extends between the first and second side supports. The plurality of web support members include a top web support member disposed adjacent a top portion of the print area and a bottom web support member disposed adjacent a bottom portion of the print area. A printer support is configured for supporting a printer adjacent the print area. A window assembly is hingedly attached to the frame adjacent the print area. The window assembly includes a platen support member extending laterally between the first and second side supports. The window assembly is movable to provide access to the print area. At least one platen is disposed on the platen support member, the platen adapted for lateral positioning along the platen support member.

Abstract: Methods for processing hyphenated chromatographic data to delineate components of a sample are disclosed. According to one aspect, the method includes obtaining hyphenated chromatographic data points for a sample, each data point comprising at least three dimensions, one of the dimensions being a continuous dimension, and subjecting at least a portion of the data points to an algorithm that organizes the data points into discrete clusters according to the data points' continuous dimension values by starting at either a smallest or largest value and delineating at a largest gap between adjacent values within a predetermined resolution window, wherein the resulting clusters are of varying width of less than or equal to the width of the resolution window and wherein at least some of the clusters are indicative of components of the sample.

Abstract: A bracket for a printer includes a frame with first and second side supports. A print area is defined in part by the side supports. A plurality of web support members laterally extends between the first and second side supports. The plurality of web support members include a top web support member disposed adjacent a top portion of the print area and a bottom web support member disposed adjacent a bottom portion of the print area. A printer support is configured for supporting a printer adjacent the print area. A window assembly is hingedly attached to the frame adjacent the print area. The window assembly includes a platen support member extending laterally between the first and second side supports. The window assembly is movable to provide access to the print area. At least one platen is disposed on the platen support member, the platen adapted for lateral positioning along the platen support member.

Abstract: A content and traffic managing system operatively associated with and a computer implemented method of managing traffic of a mobile device exhibiting communication functionality. The mobile device is connectable to users and to content providers via communication links. The system tracks various parameters over time, and schedules communication, both in relation to predefined or projected content responsive of the following: users' content related behavior, users' communication behavior, users' external behavior, and parameters of communication links.

Abstract: A headspace insulator for a battery cell operatively coupled to circuitry within an implantable medical device in including one or more of the following: (a) a body of electrically and thermally insulating material disposed between a battery electrode assembly and a battery cover, (b) a receiving area within the body that receives and isolates a battery feedthrough pin, (c) an indentation within the receiving area retaining the feedthrough pin within the receiving area, (d) a raised portion coupled to a battery cover providing an air gap between the cover and the headspace insulator near case-to-cover weld areas, (e) a feedthrough aperture adapted to receive a feedthrough assembly, (f) a pin aperture that receives the feedthrough pin, (g) a fillport aperture for electrolyte fluid flow through the headspace insulator, and (h) a slot that locates a battery weld bracket and isolates it from the feedthrough pin.

Abstract: A headspace insulator for a battery cell operatively coupled to circuitry within an implantable medical device in including one or more of the following: (a) a body of electrically and thermally insulating material disposed between a battery electrode assembly and a battery cover, (b) a receiving area within the body that receives and isolates a battery feedthrough pin, (c) an indentation within the receiving area retaining the feedthrough pin within the receiving area, (d) a raised portion coupled to a battery cover providing an air gap between the cover and the headspace insulator near case-to-cover weld areas, (e) a feedthrough aperture adapted to receive a feedthrough assembly, (f) a pin aperture that receives the feedthrough pin, (g) a fillport aperture for electrolyte fluid flow through the headspace insulator, and (h) a slot that locates a battery weld bracket and isolates it from the feedthrough pin.

Abstract: Provided herein are ready-to-use premixed pharmaceutical compositions of nicardipine or a pharmaceutically acceptable salt and methods for use in treating cardiovascular and cerebrovascular conditions.

Abstract: An electrochemical cell of an implantable medical device is provided. The electrochemical cell comprises a conductive case and a cover welded to the case to form a hermetically-sealed housing. A cathode is disposed adjacent to a surface of the case within the hermetically-sealed housing and an anode is disposed within the hermetically-sealed housing. An immobilization system is disposed between the anode and the hermetically-sealed housing. The immobilization system is configured to minimize movement of the anode relative to the housing and is adapted to thermally insulate the anode during fabrication of the hermetically-sealed housing.

Abstract: An electrochemical cell, comprising: an encasement including a case having a bottom and a sidewall terminating at an open top and a cover disposed over the case open top and hermetically sealed to the case, the encasement defining an interior space for containing cell components; and an access port defining at least one lumen extending through any of the case bottom, the case sidewall or the cover for receiving a liquid electrolyte, the access port being sealed closed after receiving the liquid electrolyte using a fusion welding method in the presence of the electrolyte.

Abstract: A process for validating an identification badge for a plurality of predetermined periods of time. The process includes generating, preferably randomly, an initial image for an initial predetermined period of time and then transmitting this initial image to a heat transfer printing device. The heat transfer device prints the image on the identification badge to thereby validate the badge for the initial predetermined period of time. Subsequently, a subsequent image is randomly generated for a subsequent predetermined period of time. This subsequent image is then transmitted to the heat transfer printing device. The device subsequently prints the subsequent image on the identification badge to overlay the initial image, thereby concealing such initial image and validating the badge for the subsequent predetermined period of time. A novel heat transfer ribbon is also provided.

Abstract: A self-expiring badge or label that includes an upper substrate having an upper surface and a lower surface and an adhesive activator layer on the lower surface. A protective layer having a first surface and a second surface is provided, with the first surface of the protective layer being removably attached to and overlaying the adhesive layer. A lower substrate is provided that has an upper surface and a lower surface, the upper surface being removably attached to and overlaying the second surface of the protective layer. A migrating ink pattern is on the lower surface of the lower substrate. To activate, the upper substrate and at least a portion of the lower substrate are removed from the protective layer to leave a remaining portion of the lower substrate having the migrating ink pattern thereon.

Abstract: A battery having an electrode assembly located in a housing that efficiently utilizes the space available in many implantable medical devices is disclosed. The battery housing provides a cover and a shallow case a preferably planar, major bottom portion, an open top to receive the cover opposing the bottom portion, and a plurality of sides being radiused at intersections with each other and with the bottom to allow for the close abutting of other components located within the implantable device while also providing for efficient location of the battery within an arcuate edge of the device. The cover and the shallow case being substantially hermetically sealed by a laser weld technique and an insulator member disposed within the case to provide a barrier to incident laser radiation so that during welding radiation does not impinge upon radiation sensitive component(s) disposed within the case.

Abstract: A system and method of protecting a printer housing against moisture infiltration, including affixing a fixed covering portion over the printer housing, wherein the affixing includes exposing a printing opening of the printer housing, and securing a removable covering portion to the fixed covering portion, wherein the removable covering portion covers the printing opening.

Abstract: An electrochemical cell for use in an implantable medical device is presented. The electrochemical cell includes a cover having a first surface and a second surface separated by an outer edge. The electrochemical cell also includes a case having a planar bottom, a side extending upwardly from the planar bottom, and an open top for receiving the cover.

Abstract: Devices, systems, and methods for providing data, especially video signal data, to a remote location using low frequency bandwidths is disclosed. Transmission of low frequency bandwidths from a transmitting unit to a receiving unit located up to about 15 miles line-of-sight is possible. Adding one or more bridge antennas between the transmitting and receiving units can increase the transmission distance to hundreds of miles line-of-sight. At the receiving unit, data is retransmitted to a facility network for display and/or storage. Control of data generating devices can also be controlled remotely from the remote location or to Internet uses wherever they may be.