Patents by Inventor David Hackam

David Hackam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ARYL HYDROCARBON RECEPTOR LIGANDS AND THEIR ANALOGUES FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY DISORDERS
    Publication number: 20230357261
    Abstract: Aryl hydrocarbon receptor (AHR) agonists and their use in treating or preventing or reducing the risk of an inflammatory disorder associated with a reduced expression of an aryl hydrocarbon receptor (AHR), including necrotizing enterocolitis, for preventing, reducing the risk of, or reducing the severity of an inflammatory disorder associated with a reduced expression of an aryl hydrocarbon receptor (AHR), and as an additive to infant nutritional formulas.
    Type: Application
    Filed: September 17, 2021
    Publication date: November 9, 2023
    Inventors: David Hackam, Peng Lu, Chhinder P. Sodhi, Peter Wipf, David Kornfilt
  • Compositions and methods for treatment of inflammatory disorders
    Patent number: 11413299
    Abstract: The present invention relates to methods of treating infectious, inflammatory and post-traumatic disorders by administering various compounds newly discovered to have TLR4 inhibitory activity. In addition to methods of treatment, the present invention further provides for pharmaceutical compositions comprising said compounds, together with a suitable pharmaceutical carrier.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: August 16, 2022
    Assignees: The Johns Hopkins University, University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: David Hackam, Chhinder P. Sodhi, Peter Wipf
  • COMPOUNDS AND TREATMENTS THAT ENHANCE ENTERIC NERVOUS SYSTEM FUNCTION
    Publication number: 20220079935
    Abstract: The present inventive concepts, compositions and methods are show that the enteric glial serve to restrain the exaggerated TLR4 signaling that occurs in the premature intestinal epithelium via the release of BDNF, and that necrotizing enterocolitis (NEC) develops due to a loss of enteric glia. Compositions and methods of treatment of NEC and related enteric disease in prenatal, premature and neonatal subjects using compositions heretofore unknown for inhibition of NEC or activation of enteric glia are also provided.
    Type: Application
    Filed: January 9, 2020
    Publication date: March 17, 2022
    Inventors: David Hackam, Peng Lu, Chhinder P. Sodhi
  • DENDRIMER COMPOSITIONS AND USE IN TREATMENT OF NECROTIZING ENTEROCOLITIS AND OTHER GASTROINTESTINAL DISORDERS
    Publication number: 20220080056
    Abstract: A dendrimer formulation, such as a PAMAM dendrimer or a multiarm PEG polymeric formulation has been developed for oral administration to the gastrointestinal tract for treatment of inflammatory diseases associated with infection or cancer. In the preferred embodiment, the dendrimers are in the form of dendrimer nanoparticles comprising poly(amidoamine) (PAMAM) hydroxyl-terminated dendrimers covalently linked to at least one therapeutic, prophylactic or diagnostic agent for treatment of one or more symptoms of necrotizing enterocolitis.
    Type: Application
    Filed: September 24, 2021
    Publication date: March 17, 2022
    Inventors: David Hackam, Sujatha Kannan, Kannan Rangaramanujam, Diego F. Nino, Fan Zhang
  • COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATORY DISORDERS
    Publication number: 20210128594
    Abstract: The present invention relates to methods of treating infectious, inflammatory and post-traumatic disorders by administering various compounds newly discovered to have TLR4 inhibitory activity. In addition to methods of treatment, the present invention further provides for pharmaceutical compositions comprising said compounds, together with a suitable pharmaceutical carrier.
    Type: Application
    Filed: April 21, 2020
    Publication date: May 6, 2021
    Inventors: David Hackam, Chhinder P. Sodhi, Peter Wipf
  • Compositions and methods for treatment of inflammatory disorders
    Patent number: 10668092
    Abstract: The present invention relates to methods of treating infectious, inflammatory and post-traumatic disorders by administering various compounds newly discovered to have TLR4 inhibitory activity. In addition to methods of treatment, the present invention further provides for pharmaceutical compositions comprising said compounds, together with a suitable pharmaceutical carrier.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: June 2, 2020
    Assignees: The John Hopkins University, University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: David Hackam, Chhinder P. Sodhi, Peter Wipf
  • ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY DISORDERS
    Publication number: 20200138821
    Abstract: Aryl hydrocarbon receptor (AHR) agonists and their use for treating, preventing, or reducing the risk of necrotizing enterocolitis in premature infants are disclosed.
    Type: Application
    Filed: May 25, 2018
    Publication date: May 7, 2020
    Inventors: David Hackam, Peng Lu, Chhinder P. Sodhi, Jun O. Liu
  • DENDRIMER COMPOSITIONS AND USE IN TREATMENT OF NECROTIZING ENTEROCOLITIS AND OTHER GASTROINTESTINAL DISORDERS
    Publication number: 20170119897
    Abstract: A dendrimer formulation, such as a PAMAM dendrimer or a multiarm PEG polymeric formulation has been developed for oral administration to the gastrointestinal tract for treatment of inflammatory diseases associated with infection or cancer. In the preferred embodiment, the dendrimers are in the form of dendrimer nanoparticles comprising poly(amidoamine) (PAMAM) hydroxyl-terminated dendrimers covalently linked to at least one therapeutic, prophylactic or diagnostic agent for treatment of one or more symptoms of necrotizing enterocolitis.
    Type: Application
    Filed: October 31, 2016
    Publication date: May 4, 2017
    Inventors: David Hackam, Sujatha Kannan, Kannan Rangaramanujam, Diego F. Nino, Fan Zhang