Patents by Inventor David Hafler

David Hafler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MEANS TO TREAT AUTOIMMUNITY BY REFINING REGULATORY T CELLS
    Publication number: 20260117178
    Abstract: The present disclosure provides methods for restoring regulatory T cell (Treg) function. Methods of treating a disease (e.g., an autoimmune disease or a cancer) in a subject in need thereof are also disclosed. The present disclosure further provides methods of screening for a compound for restoring Treg function.
    Type: Application
    Filed: September 15, 2023
    Publication date: April 30, 2026
    Applicant: Yale University
    Inventors: Tomokazu SUMIDA, David HAFLER
  • Selective differentiation, identification, and modulation of human TH17 cells
    Patent number: 9732320
    Abstract: The embodiments provide for the modulation of both the differentiation and activity of human TH17 cells. More specifically, human TH17 cell differentiation can modulated by TGF-? and IL-21, and their agonists and antagonists. Function of TH17 cells can be modulated by, for example, BLT1 or podoplanin, and their agonists and antagonists. Additionally, the embodiments provide for the identification of TH17 cells. More specifically, human TH17 cells specifically upregulate BLT1 and podoplanin.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: August 15, 2017
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Vijay K. Kuchroo, David E. Anderson, Estelle Bettelli, David Hafler, Mohammed Oukka
  • SELECTIVE DIFFERENTIATION, IDENTIFICATION, AND MODULATION OF HUMAN TH17 CELLS
    Publication number: 20170159016
    Abstract: The embodiments provide for the modulation of both the differentiation and activity of human Th17 cells. More specifically, human Th17 cell differentiation can modulated by TGF-? and IL-21, and their agonists and antagonists. Function of Th17 cells can be modulated by, for example, BLT1 or podoplanin, and their agonists and antagonists. Additionally, the embodiments provide for the identification of Th17 cells. More specifically, human Th17 cells specifically upregulate BLT1 and podoplanin.
    Type: Application
    Filed: October 17, 2014
    Publication date: June 8, 2017
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Vijay K. KUCHROO, David E. ANDERSON, Estelle BETTELLI, David HAFLER, Mohammed OUKKA
  • SELECTIVE DIFFERENTIATION, IDENTIFICATION, AND MODULATION OF HUMAN TH17 CELLS
    Publication number: 20150050732
    Abstract: The embodiments provide for the modulation of both the differentiation and activity of human Th17 cells. More specifically, human Th17 cell differentiation can modulated by TGF-? and IL-21, and their agonists and antagonists. Function of Th17 cells can be modulated by, for example, BLT1 or podoplanin, and their agonists and antagonists. Additionally, the embodiments provide for the identification of Th17 cells. More specifically, human Th17 cells specifically upregulate BLT1 and podoplanin.
    Type: Application
    Filed: October 17, 2014
    Publication date: February 19, 2015
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Vijay K. KUCHROO, David E. ANDERSON, Estelle BETTELLI, David HAFLER, Mohammed OUKKA
  • SELECTIVE DIFFERENTIATION, IDENTIFICATION, AMD MODULATION OF HUMAN TH17 CELLS
    Publication number: 20110245107
    Abstract: The embodiments provide for the modulation of both the differentiation and activity of human TH17 cells. More specifically, human TH17 cell differentiation can modulated by TGF-? and IL-21, and their agonists and antagonists. Function of TH17 cells can be modulated by, for example, BLT1 or podoplanin, and their agonists and antagonists. Additionally, the embodiments provide for the identification of TH17 cells. More specifically, human TH17 cells specifically upregulate BLT1 and podoplanin.
    Type: Application
    Filed: January 21, 2009
    Publication date: October 6, 2011
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Vijay K. Kuchroo, David E. Anderson, Estelle Bettelli, David Hafler, Mohamed Oukka