Abstract: Compositions and methods are provided for the detection of a urinary tract infection by detecting and quantitating at least eight proteins in the sample. Aptamer based proteomic analysis revealed a urine protein signature that differentiated urinary tract infections from culture negative urine samples, regardless of pyuria status. Inclusion of these candidate biomarkers, either alone or in combination, to traditional urinalysis biomarkers assist clinicians in identifying true urinary tract infections, from culture negative pyuria, at the point of care The identified patients can then be treated with a therapeutic pharmaceutical composition comprising standard antibiotics.

Abstract: Compositions and methods are provided for the detection of a urinary tract infection by detecting and quantitating at least eight proteins in the sample. Aptamer based proteomic analysis revealed a urine protein signature that differentiated urinary tract infections from culture negative urine samples, regardless of pyuria status. Inclusion of these candidate biomarkers, either alone or in combination, to traditional urinalysis biomarkers assist clinicians in identifying true urinary tract infections, from culture negative pyuria, at the point of care The identified patients can then be treated with a therapeutic pharmaceutical composition comprising standard antibiotics.

Abstract: Methods, devices and compositions for diagnosing, predicting and monitoring a urinary tract infection in a subject are described. The detection, prediction and monitoring of a urinary tract infection in a subject by detection of HD5 in the urine of a subject is described.

Abstract: Described herein are compounds and compositions comprising antimicrobial peptides and methods for their use.

Abstract: Methods, devices and compositions for diagnosing, predicting and monitoring a urinary tract infection in a subject are described. The detection, prediction and monitoring of a urinary tract infection in a subject by detection of HD5 in the urine of a subject is described.

Abstract: Methods of identifying a subject having a urinary tract infection using RNase 7 are described. The methods include providing a test sample of urine from the subject, determining the level of RNase 7 in the test sample, and then comparing the level of RNase 7 in the test sample to the level of RNase 7 in a control. A higher level of RNase 7 in the test sample indicates that the subject has an acute urinary tract infection, whereas a lower level of RNase 7 in the test sample indicates that the subject only has a chronic urinary tract infection.