Patents by Inventor David Hakes

David Hakes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Factor IX: remodeling and glycoconjugation of factor IX
    Publication number: 20080305991
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: January 23, 2007
    Publication date: December 11, 2008
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert J. Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Galactosyl nucleotide sugars
    Patent number: 7439043
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: October 21, 2008
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • GALACTOSYL NUCLEOTIDE SUGAR
    Publication number: 20080206808
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: April 9, 2003
    Publication date: August 28, 2008
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Sialic acid nucleotide sugars
    Patent number: 7399613
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: July 15, 2008
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Factor VIII: Remodeling and glycoconjugation of factor VIII
    Publication number: 20080070275
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: December 26, 2006
    Publication date: March 20, 2008
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Vectors for Recombinant Protein Expression in E. Coli
    Publication number: 20080058245
    Abstract: The present invention relates to methods of providing a protein product to a customer. In particular, the invention relates methods of using protein expression vectors to produce proteins to be provided to a client. The invention also provides vectors for the cloning and expression of proteins, including reagent proteins and therapeutic proteins.
    Type: Application
    Filed: January 6, 2005
    Publication date: March 6, 2008
    Inventors: Karl F. Johnson, Dan Bezila, Winnie Ngo, David Hakes
  • Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
    Publication number: 20080050772
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: January 11, 2007
    Publication date: February 28, 2008
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Methods of Refolding Mammalian Glycosyltranferases
    Publication number: 20070269879
    Abstract: The present invention provides methods of refolding mammalian glycosyltransferases that have been produced in bacterial cells, and methods to use such refolded glycosyltransferases, including glycosyltransferase mutants that have enhanced ability to be refolded. The invention also provides methods of refolding more than one glycosyltransferase in a single vessel, methods to use such refolded glycosyltransferases, and reaction mixtures comprising the refolded glycosyltransferases.
    Type: Application
    Filed: February 4, 2005
    Publication date: November 22, 2007
    Applicant: Neose Technologies, Inc.
    Inventors: Sami Saribas, David Hakes, Scott Willett, Karl Johnson, Daniel Bezila, Shawn Defrees
  • Interferon alpha: remodeling and glycoconjugation of interferon alpha
    Patent number: 7297511
    Abstract: The invention includes a multitude of methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: November 20, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Glycoconjugation methods and proteins/peptides produced by the methods
    Patent number: 7265085
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: September 4, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Interferon beta: remodeling and glycoconjugation of interferon beta
    Patent number: 7226903
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: June 5, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Cyclodextrin affinity purification
    Publication number: 20070105192
    Abstract: A method of immobilizing a molecular species that include a starch-binding domain is provided. There also is provided a material upon which the molecular species is immobilized, and a material that is capable of immobilizing the species The method includes binding the species to a solid support, e.g., membranes, chromatographic supports and the like. The immobilized species is optionally purified by the method of the invention. Alternatively, the immobilized species is use in another method, such as in a synthesis as a synthetic reagent, or to purify another species that has an affinity for the immobilized species. Exemplary immobilized molecular species include bioactive agents, and biomolecules.
    Type: Application
    Filed: May 5, 2004
    Publication date: May 10, 2007
    Inventors: Joseph Villafranca, David Hakes, Karl Johnson, Walter Willett, Chester Meyers
  • ERYTHROPOIETIN: REMODELING AND GLYCOCONJUGATION OF ERYTHROPOIETIN
    Publication number: 20070042458
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: April 9, 2003
    Publication date: February 22, 2007
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
    Patent number: 7173003
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: February 6, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Erythropoietin: remodeling and glycoconjugation of erythropoietin
    Publication number: 20070027068
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: October 8, 2003
    Publication date: February 1, 2007
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, David Hakes, Caryn Bowe, Xi Chen
  • Glycopegylation methods and proteins/peptides produced by the methods
    Publication number: 20070026485
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: April 9, 2004
    Publication date: February 1, 2007
    Applicant: NEOSE TECHNOLOGIES, INC.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, David Hakes, Caryn Bowe, Xi Chen
  • Factor VIII remodeling and glycoconjugation of Factor VIII
    Patent number: 7157277
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: January 2, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Glycoconjugates including more than one peptide
    Patent number: 7125843
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: October 24, 2006
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Erythropoietin: remodeling and glycoconjugation of erythropoietin
    Publication number: 20060088906
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: July 15, 2005
    Publication date: April 27, 2006
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen
  • Remodeling and glycoconjugation of peptides
    Publication number: 20060030521
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide.
    Type: Application
    Filed: July 15, 2005
    Publication date: February 9, 2006
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen