Patents by Inventor David Halter
David Halter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11199546Abstract: A method for stratification of a patient for assessing suitability of a therapy for the patient suffering from an ER (estrogen receptor) and/or PR (progesterone receptor) positive and HER2 (human epidermal growth factor receptor 2) negative cancer, the therapy being directed towards a signaling pathway, includes: (i) determining an activation status of an ER and/or PR signaling pathway by applying a Proximity Ligation Assay to detect in a tissue sample of the patient a presence of at least one member of the ER family, the at least one member being part of a transcription factor complex, and at least one protein selected from a group consisting of TAFs (TATA-binding protein associated factor), TBP (TATA-box binding protein), POLII (RNA polymerase II), TFII (transcription factor H), p300, CREB (cyclic-AMP response element-binding protein), and CBP (CREB binding protein), wherein the at least one protein is part of the same transcription factor complex.Type: GrantFiled: January 21, 2015Date of Patent: December 14, 2021Assignee: KONINKLIKE PHILIPS N.V.Inventors: David Halter, Reinhold Wimberger-Friedl, Anja Van De Stolpe, Freek Van Hemert, Geeske Christina Dam-De Veen
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Patent number: 11048911Abstract: The present invention relates to an apparatus (10) for determining cellular composition in one or more tissue sample microscopic images. It is described to provide (210) first image data of at least one tissue sample. The first image data relates to a non-specific staining of a tissue sample of the at least one tissue sample. Second image data of the at least one tissue sample is provided (220). The second image data relates to specific staining of a tissue sample of the at least one tissue sample. Either (i) the tissue sample that has undergone specific staining is the same as the tissue sample that has undergone non-specific staining, or (ii) the tissue sample that has undergone specific staining is different to the tissue sample that has undergone non-specific staining. A non-specific cellular composition cell density map is determined (230) on the basis of the first image data. A specific cellular composition cell density map is determined (240) on the basis of the second image data.Type: GrantFiled: October 26, 2017Date of Patent: June 29, 2021Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Christiaan Varekamp, Reinhold Wimberger-Friedl, David Halter
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Publication number: 20190294859Abstract: The present invention relates to an apparatus (10) for determining cellular composition in one or more tissue sample microscopic images. It is described to provide (210) first image data of at least one tissue sample. The first image data relates to a non-specific staining of a tissue sample of the at least one tissue sample. Second image data of the at least one tissue sample is provided (220). The second image data relates to specific staining of a tissue sample of the at least one tissue sample. Either (i) the tissue sample that has undergone specific staining is the same as the tissue sample that has undergone non-specific staining, or (ii) the tissue sample that has undergone specific staining is different to the tissue sample that has undergone non-specific staining. A non-specific cellular composition cell density map is determined (230) on the basis of the first image data. A specific cellular composition cell density map is determined (240) on the basis of the second image data.Type: ApplicationFiled: October 26, 2017Publication date: September 26, 2019Inventors: CHRISTIAAN VAREKAMP, REINHOLD WIMBERGER-FRIEDL, DAVID HALTER
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Patent number: 10384051Abstract: The present application relates to a device for the electroporation of bacterial cells in or on a surface of the Stratum corneum layer of a person's skin. It comprises electrodes positionable in the vicinity of said surface; a generator to supply a voltage to the electrodes to generate an electrical field having a strength in the order of 25 to 35 KV/cm at said surface of the Stratum corneum layer to inactivate bacterial cells in or on said surface. The electrodes are configured so that the strength of the electrical field reduces as a function of the depth of penetration into the skin from 25 to 35 KV/cm at said surface to 3 KV/cm or less at a depth of penetration that does not exceed 15 microns.Type: GrantFiled: April 29, 2015Date of Patent: August 20, 2019Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Eduard Gerard Marie Pelssers, Mark Thomas Johnson, Johannes Hendrikus Maria Spruit, David Halter, Roland Cornelis Martinus Vulders, Robby Petrus Cornelis Van Dreumel, Marco Baragona
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Publication number: 20170043154Abstract: The present application relates to a device for the electroporation of bacterial cells in or on a surface of the Stratum corneum layer of a person's skin. It comprises electrodes positionable in the vicinity of said surface; a generator to supply a voltage to the electrodes to generate an electrical field having a strength in the order of 25 to 35 KV/cm at said surface of the Stratum corneum layer to inactivate bacterial cells in or on said surface. The electrodes are configured so that the strength of the electrical field reduces as a function of the depth of penetration into the skin from 25 to 35 KV/cm at said surface to 3 KV/cm or less at a depth of penetration that does not exceed 15 microns.Type: ApplicationFiled: April 29, 2015Publication date: February 16, 2017Inventors: EDUARD GERARD MARIE PELSSERS, MARK THOMAS JOHNSON, JOHANNES HENDRIKUS MARIA SPRUIT, DAVID HALTER, ROLAND CORNELIS MARTINUS VULDERS, ROBBY PETRUS CORNELIS VAN DREUMEL, MARCO BARAGONA
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Publication number: 20160334405Abstract: The present invention primarily relates to a method for stratification of a patient for assessing the suitability of a therapy. The invention also relates to a method for the prognosis of the outcome of a disease of a patient and a method for the prediction and/or detection of therapy resistance of a patient towards a therapy. Furthermore, the invention relates to a novel kit, and corresponding uses thereof.Type: ApplicationFiled: January 21, 2015Publication date: November 17, 2016Inventors: DAVID HALTER, REINHOLD WIMBERGER-FRIEDL, ANJA VAN DE STOLPE, FREEK VAN HEMERT, GEESKE CHRISTINA DAM-DE VEEN
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Publication number: 20120190793Abstract: The present invention relates to a method for the production of scaffold materials and/or scaffolds for tissue and/or organ engineering, said method comprising the addition of at least one anchoring unit for a labelling agent, to at least one scaffold material and/or to at least one scaffold.Type: ApplicationFiled: November 19, 2009Publication date: July 26, 2012Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: David Halter, Ralph Kurt, Emiel Peeters, Roel Penterman, Dirk Jan Broer, Rudolf Mathias Johannes Nicolaas Lamerichs
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Publication number: 20110293712Abstract: The present invention provides for the coaxial encapsulation of a plurality of cells in a single elongated compartment. By this encapsulation, the cells are protected by at least one layer of separation material and kept in close contact, which leads to a better vitality of the encapsulated cells and consequently results in higher chances to form microtissue. Methods and devices for the production of such encapsulated cell compartments are disclosed as well as medical uses of such compartments in cell, tissue therapy and tissue engineering.Type: ApplicationFiled: November 26, 2009Publication date: December 1, 2011Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Ralph Kurt, Emiel Peeters, Roel Penterman, Dirk J. Broer, David Halter
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Publication number: 20110243852Abstract: The present invention is related to scaffolds for tissue engineering and organ engineering. More particularly, the present invention is related to a method for the production of a labelled scaffold for tissue and/or organ engineering comprising a reactive fluorinated surfactant, which serve as imaging label for medical imaging means, like CT, MRI, PET, scintigraphy and/or ultrasound imaging and the like.Type: ApplicationFiled: December 7, 2009Publication date: October 6, 2011Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Emiel Peeters, David Halter, Dirk Jan Broer, Roel Penterman
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Publication number: 20110165671Abstract: The present invention is related to a process for providing an assembly of cell microcarriers, comprising the steps of providing planar, two-dimensional objects having two sides (“flakes”), wherein these objects comprise a material which, upon application of an extrinsic stimulus, is transferred from the planar state into a rolled state, providing cells on one side of said flakes (“cell-bearing side”), transferring the flakes from the planar state into a rolled state (“cell wrap”) by application of said extrinsic stimulus, and coupling at least one type of binding agent to the flakes.Type: ApplicationFiled: June 26, 2009Publication date: July 7, 2011Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: David Halter, Emiel Peeters, Roel Penterman, Ralph Kurt, Dirk Jan Broer
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Publication number: 20110071051Abstract: The present invention relates to a bio chip for fractionating and detecting analytes, such as proteins, protein-complexes, metabolites, glycoproteins, peptides, DNA, RNA, lipids, fatty acids, carbohydrates and/or other ampholytes.Type: ApplicationFiled: May 19, 2009Publication date: March 24, 2011Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: David Halter, Ralph Kurt, Roel Penterman, Emiel Peeters, Dirk Jan Broer
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Publication number: 20110070469Abstract: A micro system power supply (1) comprises a compartment (7), at least one ion sink void (51, 52) being separated from the compartment (7) by ion pervious separation means (61, 62), a first electrode (41) being arranged in the ion sink void, and a second electrode (42). Such a micro system power supply (1) allows to provide power for a micro system, such as, e.g., an implantable micro device, a MEMS, a bioMEMS, or the like, wherein the micro system power supply (1) can be comparably efficiently manufactured in a manner to be comparably environmentally friendly disposable.Type: ApplicationFiled: May 19, 2009Publication date: March 24, 2011Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Dirk Jan Broer, Roel Penterman, Emiel Peeters, Ralph Kurt, David Halter, Hendrik De Koning