Abstract: A process for the preparation of a compound of formula (I), or a salt, hydrate or solvate thereof; wherein R1 and R2 are each independently hydrogen, or C1-6 alkyl groups or R1 and R2 are linked and, together with the cyclopentane carbon atoms to which they are attached, form a cyclopropyl ring.

Abstract: The present invention is concerned with a novel process for the preparation of the compound 5-[[2(R)-[1(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4 -tria-zol-3-one. This compound is useful as a substance P (neurokinin-1) receptor antagonist. In particular, the compound is useful e.g., in the treatment of psychiatric disorders, inflammatory diseases and emesis.

Abstract: A process for the preparation of a compound of formula (I), or a salt, hydrate or solvate thereof; wherein R1 and R2 are each independently hydrogen, or C1-6 alkyl groups or R1 and R2 are linked and, together with the cyclopentane carbon atoms to which they are attached, form a cyclopropyl ring.

Abstract: The present invention is directed to the improved synthesis of compounds of formula (I) an intermediate compound which is useful in the synthesis of the anticancer agents known as PSA conjugates.

Abstract: A method and system for automated video quality assessment which reduces the adverse effects of sub-field/frame misalignments between the reference and test sequences. More particularly, the invention provides for misalignments down to a sub-field/frame level to be handled by individually matching sub-field/frame elements of a test video field/frame with sub-field/frame elements from a reference video field/frame. The use of a matching element size that is significantly smaller than the video field/frame size enables transient sub-field/frame misalignments to be effectively tracked.

Abstract: The present invention is concerned with a novel process for the preparation of the compound 5-[[2(R)-[1(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-tria-zol-3-one. This compound is useful as a substance P (neurokinin-1) receptor antagonist. In particular, the compound is useful e.g., in the treatment of psychiatric disorders, inflammatory diseases and emesis.

Abstract: The invention is a process for preparing 3-fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide which comprises coupling 1

Abstract: The present invention relates to a process for the preparation of morpholine derivatives of formula (I) which are useful as a therapeutic agents.

Abstract: 1

Abstract: The present invention relates to a process for the preparation of mopholine derivatives of formula (I) which are useful as a therapeutic agents.

Abstract: The present invention relates to a process for the preparation of azaindole derivatives of the formula ##STR1## wherein Q is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.1-6 alkoxy, hydroxy, aryl or arylC.sub.1-4 alkyl;one of X, Y and Z is --N.dbd. and the others are --CH.dbd.;R.sup.1 is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.1-6 alkyl substituted by a group selected from aryl or --NR.sup.2 R.sup.3 where R.sup.2 and R.sup.3 each independently represent C.sub.1-4 alkyl, or R.sup.2 and R.sup.3, together with the nitrogen atom to which they are attached, form a 4-7 membered saturated heterocyclic ring, optionally containing in the ring an oxygen or sulphur atom or a group NR.sup.4 where R.sup.4 is C.sub.1-4 alkyl, aryl or arylC.sub.1-4 alkyl; andR.sup.5 is a hydrogen atom or a group selected from C.sub.1-6 alkyl or aryl.

Abstract: An apparatus for the heat treatment of a product includes a metallic heat transfer assembly for transmitting heat either directly to the product or to a mould containing the product. The heat transfer assembly comprises a plurality of separate parts which are joined together either permanently or in an operationally separable manner. Each part includes a gas distribution passageway, the passageways together defining a closed loop path for receiving and circulating around the heat transfer assembly hot permanent gas from a hot gas source. One or more heat transfer passageways formed in the heat transfer assembly itself, or between the heat transfer assembly and the mould, communicate with the closed loop path in the heat transfer assembly so as to receive hot gas therefrom and lead this gas to an exhaust outlet to the atmosphere.

Abstract: An apparatus and method for the heat treatment of a product such as in the curing of rubber-like materials and the thermoforming of plastics materials. A metallic heat transfer member is provided for contacting the product to transmit heat thereto. In order to obtain a uniform temperature distribution over the heat transfer member/product interface, one or more gas distribution passageways receive hot gas from a hot gas source such as a gas burner and lead the hot gas to the heat transfer member. One or more heat transfer passageways contiguous with the heat transfer member communicate with the gas distribution passageway so as to receive hot gas from the latter passageway and lead same to an exhaust outlet.

Abstract: Apparatus and method for determining the asbestos fiber release potential of asbestos-containing compositions comprises an impact member which is repeatedly impacted with a selected area of the asbestos-containing composition and in which asbestos fibers which become airborne as a result of the impacts are collected by means of a collector system disposed around the area of impact. The invention has particular utility for the in situ testing of asbestos-containing fire-retardant compositions which have been previously applied to structural elements of buildings.