Abstract: During operation, a computer system may receive information indicating: a number of genetic molecules associated with normal tissue in a sample, and a number of tumor genetic molecules associated with a tumor in the sample. Then, the computer system may determine a sample-specific dynamic quality metric based at least in part on: a type of cancer, sequencing coverage of one or more cancer-specific genomic targets, and a first ratio of the number of tumor genetic molecules to a sum of the number tumor genetic molecules and the number of genetic molecules or a second ratio of the number of tumor genetic molecules to the number of genetic molecules. Next, based at least in part on a comparison of the sample-specific dynamic quality metric and a threshold, the computer system may selectively provide an indication of whether a mutation or the type of cancer is present in the sample.

Abstract: An integrated data repository may be generated that includes genomics information and health insurance claims data information for a common group of individuals. The health insurance claims data can be analyzed to determine insurance code identifiers that correspond to treatments provided to individuals in which a biological condition is present. The insurance code identifiers can be used to query one or more databases to obtain additional information about the treatments. A treatment reference table can be generated using the insurance claims data and the additional information obtained from the one or more databases. The treatment reference table can be used to identify cohorts of individuals that received one or more treatments in relation to the biological condition and also to determine one or more features of the individuals included in the cohorts.

Abstract: Methods and systems are provided for a compressor adapted with a movable sleeve and an active casing treatment that form separate air flow chambers. In one example, a method includes flowing intake air in a first direction through a casing to an impeller of a compressor, selectively flowing intake air from the casing through a first chamber in an opposite, second direction, the first chamber circumferentially surrounding the casing, and selectively flowing intake air in the first direction through a second chamber to the impeller, the second chamber circumferentially surrounding the first chamber. In this way, compressor surge may be mitigated without reducing compressor efficiency at higher air flow rates.

Abstract: Methods and systems are provided for expediting heating of an engine and an emissions device upon cold startup of the engine. In one example, a method may include prior to cold startup of an engine, operating an e-compressor and opening a recirculation valve of a recirculation passage coupled across the e-compressor to flow compressed intake air from an outlet of the e-compressor through the recirculation passage to an inlet of the e-compressor and starting the engine upon a temperature at the outlet of the e-compressor reaching a threshold and continuing to operate the e-compressor while the engine is on. The heated intake air resulting from the flow of compressed intake air through the recirculation passage raises a temperature of combustion and a temperature of exhaust gas, which may decrease catalyst light-off time of the emissions device.

Abstract: Methods and systems are provided for a compressor adapted with a movable sleeve and an active casing treatment that form separate air flow chambers. In one example, a method includes flowing intake air through a casing to an impeller of a compressor, and during first conditions, actuating an actuator to adjust a movable sleeve surrounding the casing from a first position to a second position and flowing intake air through a second chamber to the impeller, the movable sleeve adjusted in both a radial direction and an axial direction via a single actuating motion of the actuator. In this way, compressor surge may be mitigated without reducing compressor efficiency at higher air flow rates.

Abstract: Methods and systems are provided for a compressor having a variable inlet device and an active casing treatment. In one arrangement, a system for a compressor may include a casing forming a recirculation passage surrounding an inlet passage, an active casing treatment surrounding the inlet passage and configured to selectively control gas flow through the recirculation passage, an impeller, and a variable inlet device positioned in the inlet passage upstream of the impeller and configured to selectively reduce an effective size of the impeller. The variable inlet device and the active casing treatment may be adjusted based on operating conditions in order to increase a flow range of the compressor while providing high compressor efficiency.

Abstract: Methods and systems are provided for an engine system configured with a wide range active compressor and high pressure EGR. In one example, a compressor may include an active casing treatment with a slideable sleeve may be adjusted to direct air flow through either a choke slot and surge slot to control compressor efficiency, thereby maintaining EGR flow. In another example, the compressor may comprise a variable inlet device to regulate air flow through the compressor, thereby adjusting compressor efficiency and also maintaining EGR flow.

Abstract: Methods and systems are provided for expediting heating of an engine and an emissions device upon cold startup of the engine. In one example, a method may include prior to cold startup of an engine, operating an e-compressor and opening a recirculation valve of a recirculation passage coupled across the e-compressor to flow compressed intake air from an outlet of the e-compressor through the recirculation passage to an inlet of the e-compressor and starting the engine upon a temperature at the outlet of the e-compressor reaching a threshold and continuing to operate the e-compressor while the engine is on. The heated intake air resulting from the flow of compressed intake air through the recirculation passage raises a temperature of combustion and a temperature of exhaust gas, which may decrease catalyst light-off time of the emissions device.

Abstract: Methods and systems are provided for a compressor having a variable inlet device and an active casing treatment. In one example, a system for a compressor may include a casing forming a recirculation passage surrounding an inlet passage, an active casing treatment surrounding the inlet passage and configured to selectively control gas flow through the recirculation passage, an impeller, and a variable inlet device positioned in the inlet passage upstream of the impeller and configured to selectively reduce an effective size of the impeller. The variable inlet device and the active casing treatment may be adjusted based on operating conditions in order to increase a flow range of the compressor while providing high compressor efficiency.

Abstract: Methods and systems are provided for an engine system configured with a wide range active compressor and high pressure EGR. In one example, a compressor may include an active casing treatment with a slideable sleeve may be adjusted to direct air flow through either a choke slot and surge slot to control compressor efficiency, thereby maintaining EGR flow. In another example, the compressor may comprise a variable inlet device to regulate air flow through the compressor, thereby adjusting compressor efficiency and also maintaining EGR flow.

Abstract: Methods and systems are provided for a compressor adapted with a movable sleeve and an active casing treatment that form separate air flow chambers. In one example, a method includes flowing intake air through a casing to an impeller of a compressor, and during first conditions, actuating an actuator to adjust a movable sleeve surrounding the casing from a first position to a second position and flowing intake air through a second chamber to the impeller, the movable sleeve adjusted in both a radial direction and an axial direction via a single actuating motion of the actuator. In this way, compressor surge may be mitigated without reducing compressor efficiency at higher air flow rates.

Abstract: Methods and systems are provided for a compressor adapted with a movable sleeve and an active casing treatment that form separate air flow chambers. In one example, a method includes flowing intake air in a first direction through a casing to an impeller of a compressor, selectively flowing intake air from the casing through a first chamber in an opposite, second direction, the first chamber circumferentially surrounding the casing, and selectively flowing intake air in the first direction through a second chamber to the impeller, the second chamber circumferentially surrounding the first chamber. In this way, compressor surge may be mitigated without reducing compressor efficiency at higher air flow rates.

Abstract: This disclosure provides for a new composition of matter, said composition of matter featuring a previously unattainable combination of softness, resiliency, durability and support in a sole material for footwear, as well as a process of manufacturing said composition of matter.

Abstract: This disclosure provides for a new composition of matter, said composition of matter featuring a previously unattainable combination of softness, resiliency, durability and support in a sole material for footwear, as well as a process of manufacturing said composition of matter.

Abstract: This disclosure provides for a new composition of matter, said composition of matter featuring a previously unattainable combination of softness, resiliency, durability and support in a sole material for footwear, as well as a process of manufacturing said composition of matter.

Abstract: This disclosure provides for a new composition of matter, said composition of matter featuring a previously unattainable combination of softness, resiliency, durability and support in a sole material for footwear, as well as a process of manufacturing said composition of matter.

Abstract: An invention is provided for system security and access based on multi-dimensional location characteristics. The invention includes collecting contextual information characterizing a specific location during a first time period utilizing a contextual data collection device (CDCD), wherein the contextual information indicates specific characteristics of the location and is collected at the location. Then, a contextual location fingerprint (CLF) is created based on the collected contextual information. In general, the CLF is a data space of values mapped over specific period of time. In operation, new contextual information is collected at a location occupied by a device to be verified during a second time period. The new contextual information then is compared to the CLF and authenticating the device fir the new contextual information is within predefined parameters of the CLF.

Abstract: An invention is provided for system security and access based on multi-dimensional location characteristics. The invention includes collecting contextual information characterizing a specific location during a first time period utilizing a contextual data collection device (CDCD), wherein the contextual information indicates specific characteristics of the location and is collected at the location. Then, a contextual location fingerprint (CLF) is created based on the collected contextual information. In general, the CLF is a data space of values mapped over specific period of time. In operation, new contextual information is collected at a location occupied by a device to be verified during a second time period. The new contextual information then is compared to the CLF and authenticating the device fir the new contextual information is within predefined parameters of the CLF.

Abstract: An invention is afforded for providing security for a protected network resource. The system includes a network access apparatus in communication with a receiver that receives signals from a remote source. The network access apparatus is capable of collecting current microprint data for the receiver, which is a plurality of values based on data values received at the receiver over a predefined period of time, for example, forty-five seconds. The system also includes an authentication computer in communication with the network access apparatus. The authentication computer has access to an LSDF for the receiver, which is a plurality of values based on data values received at the receiver over a predefined period of time, for example, a twenty-four hour period of time.

Abstract: An invention is afforded for providing security for a protected network resource. The system includes a network access apparatus in communication with a receiver that receives signals from a remote source. The network access apparatus is capable of collecting current microprint data for the receiver, which is a plurality of values based on data values received at the receiver over a predefined period of time, for example, forty-five seconds. The system also includes an authentication computer in communication with the network access apparatus. The authentication computer has access to an LSDF for the receiver, which is a plurality of values based on data values received at the receiver over a predefined period of time, for example, a twenty-four hour period of time.