Patents by Inventor David Harold Drewry

David Harold Drewry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anthranilamide inhibitors of aurora kinase
    Patent number: 7884098
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1? R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: February 8, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Jeffrey Michael Axten, Deborah L. Bryan, David Harold Drewry, Thomas H Faitg, Timothy Francis Gallagher, Neil W Johnson, Jiri Kasparec, Jeffrey M Ralph, Domingos J. Silva
  • Chemical Compounds
    Publication number: 20100113445
    Abstract: The present invention relates to dianilinopyrimidine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such dianilinopyrimidine derivatives are useful in the treatment of diseases associated with inappropriate Wee1 kinase activity.
    Type: Application
    Filed: March 12, 2008
    Publication date: May 6, 2010
    Inventors: Felix Deanda, JR., David Harold Drewry, Paul Reid
  • Chemical Compounds
    Publication number: 20100105674
    Abstract: The present invention relates to dianilinopyrimidine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such dianilinopyrimidine derivatives are useful in the treatment of diseases associated with inappropriate Wee1 kinase activity.
    Type: Application
    Filed: March 12, 2008
    Publication date: April 29, 2010
    Inventors: Felix Deanda Jr., David Harold Drewry, James Andrew Linn, Paul Reid
  • ANTHRANILAMIDE INHIBITORS OF AURORA KINASE
    Publication number: 20100016318
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1? R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Application
    Filed: January 25, 2008
    Publication date: January 21, 2010
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Jeffrey Michael Axten, Deborah L. Bryan, David Harold Drewry, Thomas H. Faitg, Timothy Francis Gallagher, Neil W. Johnson, Jiri Kasparec, Jeffrey M. Ralph, Domingos J. Silva
  • Aminopyrazine derivatives and compositions
    Patent number: 7598251
    Abstract: The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such aminopyrazine derivatives are useful in the treatment of diseases associated with inappropriate tyrosine and/or serine/threonine kinase activity.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: October 6, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael John Alberti, David Harold Drewry, David Drysdale Miller, Paul Bamborough
  • Indazolo-tetrahydropyrimidine-carboxamide derivative kinase inhibitors
    Patent number: 7560467
    Abstract: The present invention relates to indazolo-tetrahydropyrimidine-carboxamide derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such indazolo-tetrahydropyrimidine-carboxamide derivatives are useful in the treatment of diseases associated with inappropriate ROCK-1 kinase.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: July 14, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: David Harold Drewry, Brian Evans, Krista B. Goodman, Darren Victor Steven Green, David Kendall Jung, Dennis Lee, Robert A. Stavenger, Sjoerd Nocolaas Wadman
  • AMINOPYRAZINE DERIVATIVES AND COMPOSITIONS
    Publication number: 20090062307
    Abstract: The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such aminopyrazine derivatives are useful in the treatment of diseases associated with inappropriate tyrosine and/or serine/threonine kinase activity.
    Type: Application
    Filed: October 31, 2008
    Publication date: March 5, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Michael John Alberti, David Harold Drewry, David Drysdale Miller, Paul Bamborough
  • Aminopyrazine derivatives and compositions
    Patent number: 7459454
    Abstract: The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medcicaments. Such aminopyrazine derivatives are useful in the treatment of diseases associated with inappropriate tyrosine and/or serine/threonine kinase activity.
    Type: Grant
    Filed: March 18, 2004
    Date of Patent: December 2, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael John Alberti, David Harold Drewry, David Drysdale Miller, Paul Bamborough
  • Chemical Compounds
    Publication number: 20080293716
    Abstract: There is provided a compound of Formula (I) or a salt, solvate, or physiologically functional derivative thereof:
    Type: Application
    Filed: January 28, 2005
    Publication date: November 27, 2008
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: David Harold Drewry, Robert Neil Hunter, III, David Kendall Jung, James Andrew Linn, Clark Sehon, Robert A. Stavenger
  • Chemical Compounds
    Publication number: 20080275062
    Abstract: There is provided compounds of Formula (I) and salts, solvates, and physiologically functional derivatives thereof: wherein R1 is hydrogen or C1-6alkyl; n is 1, 2, 3 or 4; R2 is aryl, optionally substituted by one or two groups selected from the group consisting of halogen, hydroxy, cyano, C1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkyl, haloC1-4alkoxy, aryl, aryloxy, C1-4alkoxycarbonyl, C1-4alkylsulfonyl and a group R3R4NSO2 (wherein R3 and R4 are independently hydrogen or C1-4alkyl) and a 5- or 6-membered heteroaryl group; or n is 0 and R1 and R2, together with the nitrogen atom to which they are joined, form a 5- or 6-membered monocyclic heterocyclic ring or a 9- or 10-membered bicyclic heterocyclic ring wherein at least the ring which contains the nitrogen atom to which R1 and R2 are joined is non-aromatic, and wherein the 5- or 6-membered monocyclic heterocyclic ring or the 9- or 10-membered bicyclic heterocyclic ring is optionally substituted by one or two groups selected from the group consistin
    Type: Application
    Filed: January 28, 2005
    Publication date: November 6, 2008
    Inventors: David Harold Drewry, David Kendall Jung, James Andrew Linn, Robert Neil Hunter, Dennis Lee, Robert A. Stavenger, Clark Sehon
  • Benzimidazol-1-YL-thiophene compounds for the treatment of cancer
    Publication number: 20080269298
    Abstract: The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
    Type: Application
    Filed: May 1, 2008
    Publication date: October 30, 2008
    Inventors: Clarence W. Andrews, Mui Cheung, Ronda G. Davis-Ward, David Harold Drewry, Kyle Allen Emmitte, Robert Dale Hubbard, Kevin W. Kuntz, James Andrew Linn, Robert Anthony Mook, Gary Keith Smith, James Marvin Veal
  • Inhibitors of Akt Activity
    Publication number: 20080255143
    Abstract: Invented are novel 1H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
    Type: Application
    Filed: July 28, 2004
    Publication date: October 16, 2008
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Dirk A. Heerding, Tammy J. Clark, David Harold Drewry, Jack Dale Leber, Igor Safonov, Dennis S. Yamashita
  • Compounds
    Publication number: 20080194561
    Abstract: A compound of formula (I): compositions and medicaments containing the same as well as processes for the preparation and use of such compounds, compositions and medicaments, particularly in diseases associated with inappropriate Aurora activity.
    Type: Application
    Filed: July 13, 2006
    Publication date: August 14, 2008
    Inventors: Jerry Leroy Adams, David Harold Drewry, James Andrew Linn
  • Chemical Compounds
    Publication number: 20080058515
    Abstract: Indazolylacrylamide derivatives, which are useful as SGK-1 inhibitors are described herein. The described invention also includes methods of making such indazolylacrylamide derivatives as well as methods of using the same in the treatment of diseases mediated by inappropriate SGK-1 activity.
    Type: Application
    Filed: July 23, 2004
    Publication date: March 6, 2008
    Inventors: David Harold Drewry, James Andrew Linn, James Marvin Veal
  • Chemical compounds
    Patent number: 7329678
    Abstract: Benzimidazolyl-pyridine derivatives, which are useful as SGK-1 inhibitors are described herein. The described invention also includes methods of making such benzimidazolyl-pyridine derivatives as well as methods of using the same in the treatment of diseases mediated by inappropriate SGK-1 activity.
    Type: Grant
    Filed: January 27, 2004
    Date of Patent: February 12, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: David Harold Drewry, Robert Neil Hunter, III
  • Aminopyridine derivatives as estrogen receptor modulators
    Patent number: 7276523
    Abstract: Aminopyridine derivatives of the following formula I which exhibit pharmacological activity at estrogen receptors alpha (ER?) and beta (ER?) are described herein. The described invention also includes compositions and medicaments containing the aminopyridine derivatives as well as processes for the preparation and use of such compounds, compositions and medicaments.
    Type: Grant
    Filed: March 20, 2002
    Date of Patent: October 2, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: David Harold Drewry, Brad Richard Henke
  • Imidazoline derivatives as alpha-1A adrenoceptor ligands
    Patent number: 6884801
    Abstract: Compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed. Such compounds are useful in the treatment of Alpha-1A mediated diseases or conditions such as urinary incontinence.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: April 26, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Eric Cleveland Bigham, Michael Joseph Bishop, David Harold Drewry, Deanna Trojan Garrison, Stephen Joseph Hodson, Frank Navas, III, Jason D. Speake
  • Aminopyridine derivatives as estrogen receptor modulators
    Publication number: 20040152688
    Abstract: Aminopyridine derivatives of the following formula I which exhibit pharmacological activity at estrogen receptors alpha (ER&agr;) and beta (ER&bgr;) are described herein. The described invention also includes compositions and medicaments containing the aminopyridine derivatives as well as processes for the preparation and use of such compounds, compositions and medicaments.
    Type: Application
    Filed: March 23, 2004
    Publication date: August 5, 2004
    Inventors: David Harold Drewry, Brad Richard Henke
  • Oxindole derivatives
    Patent number: 6720332
    Abstract: Oxindole derivatives, specifically pyrrolo[3,2-f]quinoline-2-ones, which are useful as CDK4 inhibitors are described herein. The described invention also includes methods of making such oxindole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: April 13, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Scott Howard Dickerson, David Harold Drewry, James Andrew Linn
  • Oxindole derivatives
    Publication number: 20030195189
    Abstract: Oxindole derivatives, specifically pyrrolo[3,2-f]quinoline-2-ones, which are useful as CDK4 inhibitors are described herein. The described invention also includes methods of making such oxindole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Application
    Filed: February 27, 2003
    Publication date: October 16, 2003
    Inventors: Scott Howard Dickerson, David Harold Drewry, James A. Linn