Patents by Inventor David Harrison

David Harrison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220267300
    Abstract: The present disclosure relates to compounds of Formula (I) or (II): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.
    Type: Application
    Filed: June 11, 2020
    Publication date: August 25, 2022
    Inventors: Mark G. BOCK, David HARRISON, Jane E. SCANLON
  • Publication number: 20220227715
    Abstract: The present disclosure relates to compounds of Formula (I) and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.
    Type: Application
    Filed: June 11, 2020
    Publication date: July 21, 2022
    Inventors: Mark G. BOCK, David HARRISON, Jane E. SCANLON
  • Patent number: 11373419
    Abstract: Aspects of the disclosure relate to detecting unmapped drivable road surfaces. In one instance, sensor data captured by a sensor of an autonomous vehicle may be projected onto a grid having a plurality of cells. The plurality of cells may be classified by generating a label for each of the plurality of cells. Each label may identifies whether or not a corresponding cell contains a drivable surface. Ones of the plurality of cells may be clustered based on the labels to form a cluster of cells. An area of the cluster of cells may be compared to a map. Whether the area of the cluster of cells is an unmapped drivable road surface may be determined based on the comparison.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: June 28, 2022
    Assignee: Waymo LLC
    Inventors: David Harrison Silver, Ivan Bogun, Romain Thibaux
  • Publication number: 20220198199
    Abstract: The technology relates to approaches for determining appropriate stopping locations at intersections for vehicles operating in a self-driving mode. While many intersections have stop lines painted on the roadway, many others have no such lines. Even if a stop line is present, the physical location may not match what is in store map data, which may be out of date due to construction or line repainting. Aspects of the technology employ a neural network that utilizes input training data and detected sensor data to perform classification, localization and uncertain estimation processes. Based on these processes, the system is able to evaluate distribution information for possible stop locations. The vehicle uses such information to determine an optimal stop point, which may or may not correspond to a stop line in the map data. This information is also used to update the existing map data, which can be shared with other vehicles.
    Type: Application
    Filed: December 22, 2020
    Publication date: June 23, 2022
    Inventors: Romain Thibaux, David Harrison Silver, Congrui Hetang
  • Patent number: 11345669
    Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inter alia autoinflammatory and autoimmune diseases and cancers.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: May 31, 2022
    Assignee: NodThera Limited
    Inventors: David Harrison, Alan Paul Watt, Nicolas Boutard, Charles-Henry Fabritius, Michal Galezowski, Piotr Kowalczyk, Oleksandr Levenets, Jakub Woyciechowski
  • Patent number: 11327493
    Abstract: Aspects of the disclosure relate to determining whether a feature of map information. For example, data identifying an object detected in a vehicle's environment and including location coordinates is received. This information is used to identify a corresponding feature from pre-stored map information based on a map location of the corresponding feature. The corresponding feature is defined as a curve and associated with a tag identifying a type of the corresponding object. A tolerance constraint is identified based on the tag. The curve is divided into two or more line segments. Each line segment has a first position. The first position of a line segment is changed in order to determine a second position based on the location coordinates and the tolerance constraint. A value is determined based on a comparison of the first position to the second position. This value indicates a likelihood that the corresponding feature has changed.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: May 10, 2022
    Assignee: Waymo LLC
    Inventors: David Harrison Silver, David I. Ferguson
  • Patent number: 11304755
    Abstract: An introducer set for a microwave ablation probe is disclosed. The introducer set includes a cannula that is at least partially transparent to microwave energy, and a stylet sized to be received by the lumen of the cannula. Other examples provide a microwave ablation system including a microwave ablation probe having a radiating portion and a cannula that is at least partially transparent to microwave energy. The radiating portion of the probe aligns with the transparent portion of the cannula when the probe is inserted into the cannula lumen. The technology provides a method including introducing a microwave ablation probe into the lumen of a cannula having a cannula body that is at least partially transparent to microwave energy, aligning the transparent portion of the cannula with the radiating portion of the probe, and causing microwave energy to be emitted from the radiating portion of the probe.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: April 19, 2022
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Hong Cao, Kent David Harrison, Timothy A. Ostroot
  • Publication number: 20220098159
    Abstract: The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.
    Type: Application
    Filed: January 24, 2020
    Publication date: March 31, 2022
    Inventors: Mark G. BOCK, David HARRISON
  • Publication number: 20220083073
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for processing data characterizing a first region in an environment to generate a prediction characterizing a second region in the environment. One of the methods includes obtaining surfel data comprising a plurality of surfels; obtaining sensor data for a plurality of locations in a first region of the environment; determining, from the surfel data, a plurality of first surfels corresponding to respective locations in the first region of the environment; determining, using the first surfels and the sensor data, a difference between i) a first representation of the first region of the environment corresponding to the first surfels and ii) a second representation of the first region of the environment corresponding to the sensor data; and generating a respective object prediction for one or more locations in a second region of the environment.
    Type: Application
    Filed: September 15, 2020
    Publication date: March 17, 2022
    Inventors: David Harrison Silver, Carlos Hernandez Esteban, Michael Montemerlo, Peter Pawlowski, David Yonchar Margines
  • Publication number: 20220063662
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for autonomous driving with surfel maps. In some implementations, a three-dimensional representation of a real-world environment is obtained. Each of the surfels can correspond to a respective point of plurality of points in a three-dimensional space of the real-world environment. Input sensor data is received from multiple sensors installed on the autonomous vehicle. A pedestrian is detected from the input sensor data. A determination is made that the pedestrian is located behind a barrier. A driving plan is updated based on determining that the pedestrian is located behind a barrier.
    Type: Application
    Filed: August 26, 2020
    Publication date: March 3, 2022
    Inventors: Christoph Sprunk, David Harrison Silver, Carlos Hernandez Esteban, Michael Montemerlo, Peter Pawlowski, David Yonchar Margines
  • Patent number: 11226626
    Abstract: The technology relates to detecting a person directing traffic. For instance, a first vehicle may be controlled in an autonomous driving mode. Sensor data is received from a perception system of the first vehicle, the sensor data identifying a person. Behavior of the person is observed using the sensor data. The observed behavior of the person and the observed behavior of a second vehicle are used to determine a likelihood value indicative of whether the person is directing traffic. The first vehicle is maneuvered in the autonomous driving mode based on the determined likelihood value.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: January 18, 2022
    Assignee: Waymo LLC
    Inventors: David Harrison Silver, Carl Kershaw, Pankaj Chaudhari
  • Patent number: 11223899
    Abstract: The present disclosure generally relates to user interfaces and techniques for managing audio exposure using a computer system (e.g., an electronic device). In accordance with some embodiments, the electronic device displays a graphical indication of a noise exposure level over a first period of time with an area of the graphical indication that is colored to represent the noise exposure level, the color of the area transitioning from a first color to a second color when the noise exposure level exceeds a first threshold. In accordance with some embodiments, the electronic device displays noise exposure levels attributable to a first output device type and a second output device type and, in response to selecting a filtering affordance, visually distinguishes a set of noise exposure levels attributable to the second output device type.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: January 11, 2022
    Assignee: Apple Inc.
    Inventors: Nicholas Felton, Eamon Francis Gilravi, Ruchi Goswami, David Harrison, Jakub Mazur, Aroon Pahwa, Andriy Suden
  • Publication number: 20220005348
    Abstract: The technology relates to detecting and responding to emergency vehicles. This may include using a plurality of microphones to detect a siren noise corresponding to an emergency vehicle and to estimate a bearing of the emergency vehicle. This estimated bearing is compared to map information to identify a portion of roadway on which the emergency vehicle is traveling. In addition, information identifying a set of objects in the vehicle's environment as well as characteristics of those objects is received from a perception system is used to determine whether one of the set of objects corresponds to the emergency vehicle. How to respond to the emergency vehicle is determined based on the estimated bearing and identified road segments and the determination of whether one of the set of objects corresponds to the emergency vehicle. This determined response is then used to control the vehicle in an autonomous driving mode.
    Type: Application
    Filed: September 16, 2021
    Publication date: January 6, 2022
    Inventors: David Harrison Silver, Angus Leigh, Benjamin Ingram, Jennifer Taylor, Vaibhav Nangia
  • Patent number: 11216002
    Abstract: Aspects of the disclosure relate to an autonomous vehicle that may detect other nearby vehicles and designate stationary vehicles as being in one of a short-term stationary state or a long-term stationary state. This determination may be made based on various indicia, including visible indicia displayed by the detected vehicle and traffic control factors relating to the detected vehicle. For example, the autonomous vehicle may identify a detected vehicle as being in a long-term stationary state based on detection of hazard lights being displayed by the detected vehicle, as well as the absence of brake lights being displayed by the detected vehicle. The autonomous vehicle may then base its control strategy on the stationary state of the detected vehicle.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: January 4, 2022
    Assignee: Waymo LLC
    Inventors: David Harrison Silver, David I. Ferguson
  • Publication number: 20210377607
    Abstract: Approaches provide for adjustment of playback settings on a user device based at least in part on a type of content being consumed via the user device. The content type may be determined based on a fingerprint acquired from the content presented via on the client device. The content type may be associated with one or more associated playback settings based on properties of the content type, which may be stored in a content profile. The playback settings may be provided to the user device to set or adjust one or more settings of the user device, as may relate to the presentation of the content.
    Type: Application
    Filed: April 18, 2019
    Publication date: December 2, 2021
    Inventors: Ashwin NAVIN, David HARRISON
  • Patent number: 11164454
    Abstract: The technology relates to detecting and responding to emergency vehicles. This may include using a plurality of microphones to detect a siren noise corresponding to an emergency vehicle and to estimate a bearing of the emergency vehicle. This estimated bearing is compared to map information to identify a portion of roadway on which the emergency vehicle is traveling. In addition, information identifying a set of objects in the vehicle's environment as well as characteristics of those objects is received from a perception system is used to determine whether one of the set of objects corresponds to the emergency vehicle. How to respond to the emergency vehicle is determined based on the estimated bearing and identified road segments and the determination of whether one of the set of objects corresponds to the emergency vehicle. This determined response is then used to control the vehicle in an autonomous driving mode.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: November 2, 2021
    Assignee: WAYMO LLC
    Inventors: David Harrison Silver, Angus Leigh, Benjamin Ingram, Jennifer Taylor, Vaibhav Nangia
  • Publication number: 20210321961
    Abstract: Systems and method for performing X-ray computed tomography (CT) that can improve spectral separation and decrease motion artifacts without increasing radiation dose are provided. The systems and method can be used with either a kVp-switching source or a single-kVp source. When used with a kVp-switching source, an absorption grating and a filter grating can be disposed between the X-ray source and the sample to be imaged. Relative motion of the filter and absorption gratings can by synchronized to the kVp switching frequency of the X-ray source. When used with a single-kVp source, a combination of absorption and filter gratings can be used and can be driven in an oscillation movement that is optimized for a single-kVp X-ray source. With a single-kVp source, the absorption grating can also be omitted and the filter grating can remain stationary.
    Type: Application
    Filed: June 22, 2021
    Publication date: October 21, 2021
    Applicant: Rensselaer Polytechnic Institute
    Inventors: Daniel David Harrison, Ge Wang
  • Patent number: 11126868
    Abstract: Aspects of the disclosure relate controlling autonomous vehicles or vehicles having an autonomous driving mode. More particularly, these vehicles may identify and respond to other vehicles engaged in a parallel parking maneuver by receiving sensor data corresponding to objects in an autonomous vehicle's environment and including location information for the objects over time. An object corresponding to another vehicle in a lane in front of the first vehicle may be identified from the sensor data. A pattern of actions of the other vehicle identified form the sensor data is used to determine that the second vehicle is engaged in a parallel parking maneuver based on a pattern of actions exhibited by the other vehicle identified from the sensor data. The determination is then used to control the autonomous vehicle.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: September 21, 2021
    Assignee: Waymo LLC
    Inventors: David Harrison Silver, David Ian Franklin Ferguson
  • Publication number: 20210284989
    Abstract: Provided herein are methods, reagents, and kits for the isolation of sperm cells from other cell types and the purification of sperm-associated DNA from a complex sample. In particular, methods, reagents, and kits are provided for the separation of intact sperm cells from epithelial cells via binding of sperm cells to a cellulose material, and the extraction of sperm-associated DNA therefrom.
    Type: Application
    Filed: March 11, 2021
    Publication date: September 16, 2021
    Inventors: Nicholas Alan Courtney, Margaret Mary Ewing, Robert Stewart McLaren, David Harrison Warshauer
  • Publication number: 20210232152
    Abstract: The technology relates to detecting and responding to sounds for a vehicle having an autonomous driving mode. In one example, an audible signal corresponding to a sound received at one or more microphones of the vehicle may be received. Sensor data generated by a perception system of the vehicle identifying objects in an environment of the vehicle may be received. A type of sound may be determined by inputting the audible signal into a classifier. A set of additional signals may be determined based on the determined type of sound. The sensor data may be processed in order to identify one or more additional signals of the identified set of additional signals. The vehicle may be controlled in the autonomous driving mode in order to respond to the sound based on the one or more additional signals and the type of sound.
    Type: Application
    Filed: March 9, 2021
    Publication date: July 29, 2021
    Inventors: David Harrison Silver, Jennifer Taylor