Abstract: A wakeboat creates a wake, the performance level of the wake varying depending upon the mass of the wakeboat, the wakeboat including a hull; an engine supported by the hull; a controller supported by the hull; a processor coupled to the controller; a memory coupled to the processor; a sensor configured to measure at least one parameter of the wakeboat, the controller being coupled to the sensor and being configured to receive data from the sensor, the controller being configured to derive the present mass of the wakeboat from said sensor data, the controller being configured to determine the present wake performance level of the wakeboat based on the present mass of the wakeboat; anda display coupled to the controller, the controller being configured to use the display to indicate the present wake performance level of the wakeboat.

Abstract: Various of the disclosed embodiments contemplate systems and methods that compensate for the limited dynamic range of certain X-Ray detector systems, such as CAT-Scan detector systems. In some embodiments, the system alternates between different photon emission flux values and then gives more consideration to an attenuation value associated with a more favorable detection flux. In this manner, different object densities may be accounted for and may be more properly imaged despite the particular characteristics of the X-Ray system.

Abstract: Aspects of the disclosure relate to detecting and responding to stop signs. An object detected in a vehicle's environment having location coordinates may be identified as a stop sign and, it may be determined whether the location coordinates of the identified stop sign correspond to a location of a stop sign in detailed map information. Then, whether the identified stop sign applies to the vehicle may be determined based on the detailed map information or on a number of factors. Then, if the identified stop sign is determined to apply to the vehicle, responses of the vehicle to the stop sign may be determined, and, the vehicle may be controlled based on the determined responses.

Abstract: Provided herein are methods directed to the prediction and early assessment of the efficacy of cancer treatment regimens, in particular in patients undergoing therapy with a DNA-damaging chemotherapeutic agent, by determining expression levels of certain proteins found to be useful as biomarkers in circulating tumor cells obtained from the patient both prior to and post-treatment.

Abstract: A system includes a client device capable of being associated with a number of networked devices through a computer network to: process an embedded object, constrain an executable environment in a security sandbox, and execute a sandboxed application in the executable environment. The embedded object is processed through the sandboxed application. The system also includes a relevancy-matching server to: receive primary data generated from fingerprint data of each of the number of networked devices, match the primary data with targeted data based on a relevancy factor, search a storage for the targeted data, and cause rendering of the targeted data through the embedded object processed through the sandboxed application of the client device. The primary data is any one of a content identification data and a content identification history.

Abstract: A method of an attribution server is disclosed. The method includes determining that one or more request(s) is received through the computer network from a first device based on accessing first data related to renderings of a first content on the first device, and determining rendering of a second content on a second device based on accessing second data related to renderings of content on the second device. The method also includes determining that the first content and the second content are related, determining likely association of the first device and the second device with a same user, and determining that the same user is likely to have rendered the second content on the second device based on exposure thereof to the first content on the first device.

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, Y1, Y2, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract: Aspects of the disclosure relate to detecting and responding to objects in a vehicle's environment. For example, an object may be identified in a vehicle's environment, the object having a heading and location. A set of possible actions for the object may be generated using map information describing the vehicle's environment and the heading and location of the object. A set of possible future trajectories of the object may be generated based on the set of possible actions. A likelihood value of each trajectory of the set of possible future trajectories may be determined based on contextual information including a status of the detected object. A final future trajectory is determined based on the determined likelihood value for each trajectory of the set of possible future trajectories. The vehicle is then maneuvered in order to avoid the final future trajectory and the object.

Abstract: A transdermal dosing unit may include a first segment having a first pharmaceutical in a first reservoir, a first releasing compound, and a first adhesive component, a second segment removably connected to the first segment, the second segment having a second pharmaceutical in a second reservoir, a second releasing component, and a second adhesive component, and a backing component. The transdermal dosing unit may further include additional segments, and may include a perforated section between each segment. The first adhesive component may have a first adhesion strength, and the second adhesive component may have a second adhesion strength that is either different from or approximately equal to the first adhesion strength. A method of titrating a dose of such a transdermal dosing unit may include applying the transdermal dosing unit to a subject, and removing the first segment while leaving the second segment on the subject.

Abstract: Aspects of the disclosure relate to maneuvering a vehicle. As an example, sensor information identifying a set of objects as well as a set of characteristics for each object of the set of objects is received from a perception system of a vehicle. The set of objects is filtered to remove objects corresponding to vehicles, bicycles, and pedestrians. An object within an expected future path of the vehicle is selected from the filtered set of objects. The object is classified as drivable or not drivable based on the set of characteristics. Drivable indicates that the vehicle can drive over the object without causing damage to the vehicle. The vehicle is maneuvered based on the classification such that when the object is classified as drivable, maneuvering the vehicle includes driving the vehicle over the object by not altering the expected future path of the vehicle.

Abstract: A surgical access device comprises a seal assembly (51) having a plurality of part circular sealing members (55) each attached to a common ring (53) which is held within the device about its longitudinal axis. In use, the sealing members are located radially inwards of the ring in a stacked relationship. When not within the device, the sealing members are movable from a position radially outwards of the ring to a position radially inwards of the ring. A seal core comprises the seal assembly and a protective member which, in use, is located on the proximal side of the seal assembly. A method of assembling the surgical access device is also provided.

Abstract: Provided herein are methods directed to the prediction and early assessment of the efficacy of cancer treatment regimens, in particular in patients undergoing therapy with a DNA-damaging chemotherapeutic agent, by determining expression levels of certain proteins found to be useful as biomarkers in circulating tumor cells obtained from the patient both prior to and post-treatment.

Abstract: In one embodiment, a method of a relevancy-matching server includes generating a fingerprint data using a television, matching primary data generated from the fingerprint data with targeted data based on a relevancy factor, and searching a storage for the targeted data, a reference and/or a metadata. The primary data is a content identification data and/or a content identification history. An embedded object is processed using a mobile device capable of being associated with the television. An executable environment is constrained in a security sandbox of the mobile device. A sandboxed application is executed in the executable environment. The fingerprint data from the television and/or the mobile device is processed through a content identification server. The primary data from the fingerprint data is communicated to any devices with an access to identification data of the television and/or an automatic content identification service through the content identification server.

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein Q, X4, X5, X6, X7, R1, R2, R3 and R8 are as defined in the specification, processes for the preparation of such compounds, pharmaceutical compositions containing them and the use of such compounds in therapy.

Abstract: A method, apparatus, and system related to relevancy improvement through targeting of information based on data gathered from a television associated with a security sandbox of a mobile device are disclosed. In one aspect, a system may include a television to generate a fingerprint data. The fingerprint data is an audio fingerprint data and/or a video fingerprint data. A relevancy-matching server matches primary data generated from the fingerprint data with targeted data based on a relevancy factor, and searches a storage for at least one of the targeted data, a reference to the targeted data, and a metadata of the targeted data. The primary data is a content identification data and/or a content identification history. A mobile device capable of being associated with the television processes an embedded object, constrains an executable environment in a security sandbox, and executes a sandboxed application in the executable environment.

Abstract: In one embodiment, a method of a relevancy-matching server includes matching primary data generated from a fingerprint data with targeted data based on a relevancy factor and locating in a storage the targeted data, a reference and/or a metadata. A mobile device is associated with a television. An executable environment is constrained in a security sandbox of the mobile device. A sandboxed application is executed capable of bypassing at least one access control of the security sandbox. An embedded object is processed in the sandboxed application. The television and/or the mobile device is to generate the fingerprint data from characteristic features of media data. The fingerprint data from the television and/or the mobile device is processed through a content identification server. The primary data is communicated to any device with access to identification data of the television and/or an automatic content identification service.

Abstract: Aspects of the disclosure relate to determining whether a feature of map information. For example, data identifying an object detected in a vehicle's environment and including location coordinates is received. This information is used to identify a corresponding feature from pre-stored map information based on a map location of the corresponding feature. The corresponding feature is defined as a curve and associated with a tag identifying a type of the corresponding feature. A tolerance constraint is identified based on the tag. The curve is divided into two or more line segments. Each line segment has a first position. The first position of a line segment is changed in order to determine a second position based on the location coordinates and the tolerance constraint. A value is determined based on a comparison of the first position to the second position. This value indicates a likelihood that the corresponding feature has changed.

Abstract: In one embodiment, a method of a relevancy-matching server includes matching primary data generated from a fingerprint data with targeted data based on a relevancy factor, locating in a storage the targeted data, a reference to the targeted data, and/or a metadata of the targeted data. A mobile device is associated with a television. An executable environment is constrained in a security sandbox of the mobile device. A sandboxed application is executed in the executable environment capable of bypassing at least one access control of the security sandbox. An embedded object is processed in the sandboxed application. The television and/or the mobile device are to generate the fingerprint data from characteristic features of media data. The relevancy-matching server is to match the targeted data with the primary data such that the relevancy-matching server is to locate in the storage an item based on a relevancy factor.

Abstract: An apparatus and a system of improvement of advertisement targeting through embedded scripts in supply-side and demand-side platforms are disclosed. In one embodiment, a method of a client device includes applying an automatic content recognition algorithm to determine a content identifier of an audio-visual data. The client device then associates the content identifier with an advertisement data based on a semantic correlation between a meta-data of the advertisement provided by a content provider and/or the content identifier. The advertisement targeting may be improved when a script is embedded in the client device, a supply-side platform, and/or a data provider integrated with the supply side platform, to execute arbitrary cross-site scripts in the sandboxed application of the client device. The content identifier may be obfuscated in a manner that it is relevant to a particular demand-side platform to eliminate a need to query the provider of the content identifier on a per ad-spot basis.

Abstract: A method, apparatus and/or system related to discovery and launch system and method. In one embodiment, a method of a mobile device includes accessing a multicast capability of an operating system through an application of the mobile device, determining if there is a similar application locally stored on a networked media device to the application on the mobile device when a multicast message is broadcast to the networked media device communicatively coupled to the mobile device through a local area network, and either populating a table of the operating system of the client device with a list of applications and/or presenting identifiers to the client device to enable a user thereof to select an identifier therethrough.