Patents by Inventor David Haselbach

David Haselbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for analyzing biological macromolecular complexes and use thereof
    Patent number: 9366677
    Abstract: In a first aspect, provided herein is a method of determining assembly, homogeneity and/or thermodynamic stability of biological macromolecular complexes. In particular, the method allows determining maximum stability of the complexes based on fluorescence changes at an appropriate wavelength as a function of temperature whereby the fluorescence changes reflect the status of assembly, homogeneity and/or thermodynamic stability of the biological macromolecular complexes. The method is based on identifying two state and multistate unfolding fluorescence curves as a function of temperature by fitting the curves according to a multistate unfolding model. In addition, a computer program and a computer program storage medium as well as an apparatus and a system is provided for determining the assembly, homogeneity and/or thermodynamic stability of biological macromolecular complexes.
    Type: Grant
    Filed: September 6, 2011
    Date of Patent: June 14, 2016
    Assignee: Max-Planck-Gesellshaft zur Foerderung der Wissenschaften e.V.
    Inventors: Holger Stark, Ashwin Chari, David Haselbach, Jan-Martin Kirves
  • Methods for Analyzing Biological Macromolecular Complexes and use Thereof
    Publication number: 20140206092
    Abstract: In a first aspect, the present invention relates to a method of determining assembly, homogeneity and/or thermodynamic stability of biological macromolecular complexes. In particular, the method allows determining maximum stability of said complexes based on fluorescence changes at an appropriate wavelength as a function of temperature whereby said fluorescence changes reflect the status of assembly, homogeneity and/or thermodynamic stability of the biological macromolecular complexes. Said method is based on identifying two state and multistate unfolding fluorescence curves as a function of temperature by fitting said curves according to a multistate unfolding model. In addition, a computer program and a computer program storage medium as well as an apparatus and a system is provided for determining the assembly, homogeneity and/or thermodynamic stability of biological macromolecular complexes.
    Type: Application
    Filed: September 6, 2011
    Publication date: July 24, 2014
    Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschften e.V.
    Inventors: Holger Stark, Ashwin Chari, David Haselbach, Jan-Martin Kirves