Patents by Inventor David Henry Small

David Henry Small has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostic test for Alzheimer's disease
    Publication number: 20040038377
    Abstract: A method for the diagnosis of Alzheimer's disease (AD) in a patient, comprising the steps of:
    Type: Application
    Filed: August 25, 2003
    Publication date: February 26, 2004
    Inventors: Javier Saez-Valero, David Henry Small
  • Assay method
    Publication number: 20030235872
    Abstract: Methods and devices for rapid screening of drug candidates, especially candidate agents for treatment of Alzheimer's disease and stroke are disclosed. The invention provides treatment compounds and a biosensor method and device which is particularly applicable to screening libraries of compounds.
    Type: Application
    Filed: June 19, 2003
    Publication date: December 25, 2003
    Inventors: David Henry Small, Supundi Subasinghe, Marie-Isabel Aguilar
  • Method for the diagnosis of Alzheimer's Disease and other prion related disorders
    Publication number: 20020150878
    Abstract: The invention provides a method for the diagnosis of dementia and transmissible spongiform encephalopathies in a subject by detecting the levels of glycoproteins that bind wheat germ agglutinin. The invention also provides a method for diagnosis of dementia and transmissible spongiform encephalopathies in a subject by comparing the levels of glycoproteins that bind wheat germ agglutinin with the glycosylation patterns of biomarkers, acetylcholinesterase and butyrylcholinesterase.
    Type: Application
    Filed: January 17, 2002
    Publication date: October 17, 2002
    Inventors: David Henry Small, Lisa Fodero
  • Diagnostic test for alzheimer's disease
    Patent number: 6461831
    Abstract: A method for the diagnosis of Alzheimer's disease (AD) in a patient, comprising the steps of: (1) providing a sample of an appropriate body fluid from said patient; (2) detecting the presence of acetylcholinesterase (AChE) with an altered glycosylation pattern in said sample. It has been established that approximately 75-95% of the AChE in the CSF of AD patients binds to Concanavalin (Con A) or wheat germ agglutinin (WGA) but with different specificity to each. Accordingly, in order to identify the glycosylation pattern of AChE in the sample, the binding to Con A is determined, then the binding to WGA is determined, and a ratio calculated. The ratio is characteristic of the glycosylation pattern. In alternative embodiment of the invention a monoclonal antibody specific for AChE with an altered glycosylation pattern is used to detect its presence.
    Type: Grant
    Filed: September 21, 2000
    Date of Patent: October 8, 2002
    Inventors: David Henry Small, Javier Saez-Valero, Gian Sberna
  • Diagnostic test for alzheimer's disease
    Publication number: 20020022242
    Abstract: A method for the diagnosis of Alzheimer's disease (AD) in a patient, comprising the steps of:
    Type: Application
    Filed: April 9, 2001
    Publication date: February 21, 2002
    Inventors: David Henry Small, Javier Saez-Valero