Abstract: Cardiac tissue-on-a-chip platforms aimed at mimicking human cardiac tissue structures, are valuable tools to model, and serve as preclinical platforms for drug testing or therapies for cardiac repair. We have developed three types of electrospun scaffolds including furfuryl gelatin (f-gelatin) alone, with polycaprolactone (PCL) in the ratio of f-gelatin and PCL (1:1), and coaxial scaffolds with PCL (core) and f-gelatin (sheath). Scaffolds were developed through single nozzle electrospinning and coaxial electrospinning, respectively, to serve as scaffolds for cardiac tissue-on-a-chip platforms.

Abstract: The present invention relates to the treatment of secretory disorders, and provides novel methods of treatment of these disorders comprising the administration of fibroblast growth factor 21 (FGF21) or derivatives thereof. The methods of the invention are useful in conditions including exocrine pancreatic insufficiency (EPI), for example EPI resulting from cystic fibrosis, alcoholism, pancreatitis, pancreatic cancer, gallstones, celiac disease, high triglycerides, or lupus. The methods of the present invention find further utility in the treatment of salivary flow disorders, for example Sjorgen's syndrome, and the treatment of EPI or pancreatitis resulting from surgical procedures.

Abstract: According to some embodiments, a skin treatment system comprises a manifold assembly comprising at least one fluid connector to secure at least one treatment fluid container, a primary handpiece configured to hydraulically couple to the manifold assembly, wherein the primary handpiece is hydraulically coupled to the manifold assembly using at least one fluid conduit, and a flow control device positioned along the at least one fluid conduit, the flow control device configured to switch flow of treatment fluid from the at least one treatment fluid between the primary handpiece and a port, wherein the port is configured to be coupled to a secondary handpiece, wherein a vacuum source is configured to operatively couple to the system and selectively create suction along the primary handpiece.

Abstract: A cake covering assembly for protecting a cake from airborne pathogens includes a cover that is positionable over a cake. The cover is comprised of a fluid impermeable material to protect the cake from airborne pathogens. The cover has a plurality of candle openings each extending through the cover. A plurality of candle holders is provided and each of the candle holders has a receiver to insertably receive a candle. Each of the candle holders is insertable through a respective one of the candle openings having the receiver being spaced above the cover. In this way each of the candle holders can support the candle in a vertical orientation thereby facilitating the candle to be blown out by a user in the convention of blowing out birthday candles.

Abstract: In some embodiments, an electronic device facilitates version tracking of documents based on actions associated with the document. In some embodiments, an electronic device displays a representation of a second version of a content item in accordance with a determination that the electronic device has access to a first version and a second version of a content item.

Abstract: One embodiment of a trailer hitch assist system analyzes image data from a vehicle camera to detect a reference object on the ground in a first location and stores a first position, within the camera's field of view, of the reference object. The first location is directly beneath the hitch ball of the vehicle. The system analyzes additional image data to detect the reference object on the ground in a second location and stores a second position, within the camera's field of view, of the reference object. The second location is directly beneath the trailer coupler of a trailer. The system calculates a spatial relationship between the first and second locations based on the stored first and second positions and camera parameters. Based on the calculated spatial relationship, the vehicle backs autonomously to align the hitch ball and trailer coupler to permit the trailer to be hitched to the vehicle.

Abstract: The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD123 may have a second binding domain that binds to another target. In one embodiment, multi-specific polypeptide molecules bind both CD123-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD123-binding polypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.

Abstract: The present disclosure relates to antibodies that specifically bind to a tumor-associated antigen (TAA) such as PSMA and/or CD3, including bispecific antibodies that bind to a TAA (e.g., PSMA) and CD3, and compositions comprising the same. These antibodies are useful for enhancing immune responses and for the treatment of disorders, including solid tumor cancers, for example, by increasing tumor localization.

Abstract: This disclosure describes systems, methods, and devices related to providing smart communication networks using asset information in a supply chain environment. Techniques described herein may relate to collecting real-time asset tracking data for an asset, detecting an event associated with the asset, identifying two or more users to add to a smart communications groups based on historical user interactions and historical tracking data, and creating an asset-centric smart communications groups with the identified two or more users.

Abstract: A genomic data analyzer system method to analyze next generation sequencing genomic data from a sourcing laboratory. The method includes receiving, with a processor, a next generation sequencing analysis request from a sourcing laboratory, the next generation sequencing request comprising at least a raw next generation sequencing data file and the sourcing laboratory identification; identifying, with a processor, a first set of characteristics associated with the next generation sequencing analysis request, the first set of characteristics comprising at least a target enrichment technology identifier, a sequencing technology identifier, and a genomic context identifier; configuring, with a processor, a data alignment module to align the input raw sequencing data file in accordance with at least one characteristic of said first set of characteristics; and aligning, with the data alignment module processor, the input sequencing data to a genomic sequence.

Abstract: Flexible elongate devices and methods include an articulable body portion and a control structure attached with one or more pull wires that control articulation of the articulable body portion. The control structure includes a metallic material that defines a sealing surface functionalized by a primer. A polymer material disposed onto the sealing surface of the control structure creates a seal between the control structure and polymer material. Flexible elongate devices and methods also include a control structure and a pull wire configured to control articulation of the flexible elongate device. The control structure includes a plurality of control segments stacked along a longitudinal axis, where each of the control segments define a pull wire aperture, where pull wire apertures of adjacent control segments are offset relative to one another, such that a portion of the pull wire extending through the pull wire apertures has a non-linear shape.

Abstract: An emergency ventilation system ventilates a patient and includes a chamber housing defining a breathing chamber; a piston; and a motor operably connected to the piston. The motor applies an exhalation force to move the piston in an exhalation direction applies an inhalation force to move the piston in an inhalation direction. The piston increases air in the breathing chamber as the exhalation force is applied and decreases air in the breathing chamber as the inhalation force is applied. An exhalation check valve allows airflow from the air source to the breathing chamber and not to allow airflow from the breathing chamber to the air source as the inhalation force is applied. An inhalation check valve allows airflow from the breathing chamber to the air output and not to allow airflow from the air output to the breathing chamber as the exhalation force is applied.

Abstract: Method and systems for determining when to accelerate, decelerate, or maintain current speed of cruise control based on the blindspots of vehicles. Distances between a vehicle and one or more surrounding vehicles are measured using a plurality of sensors. These measurements are used to determine if a vehicle has a surrounding vehicle in its blindspot or if the vehicle is in the blindspot of the surrounding vehicle. Cost calculations are made to determine the individual cost calculations of maintaining current speed versus changing the acceleration. The lowest cost calculation is selected and implemented by the vehicle such that velocity is maintained or acceleration of the vehicle is changed.

Abstract: A method includes: identifying marking parameters associated with performance of dental appliance etching; includes identifying a first segment of marking data to be etched onto a dental appliance; causing, via dental appliance marking equipment based on the marking parameters, etching of the first segment on the dental appliance; capturing image data associated with the etching of the first segment; and causing the marking parameters to be updated based on the image data. A method includes: subsequent to dental appliances being simultaneously thermoformed via a thermoforming system in a single batch, determining dental appliance data and laser tool data; determining, based on the dental appliance data and the laser tool data, global plan data for performing laser operations of the dental appliances via laser tools; and causing, based on the global plan data via the laser tools, the laser operations of the dental appliances.

Abstract: Provided are anti-scald assemblies for a faucet housing comprising a polymeric manifold housing comprising an anti-scald cavity housing an anti-scald device, a mixing cavity housing a mixing valve, and an actuator cavity housing an actuating member. A longitudinal axis of the anti-scald cavity is at an angle between 0 and 90 degrees relative to a longitudinal axis of the actuator cavity. The anti-scald device comprises a thermal actuator coupled to a plunger, wherein the thermal actuator and the plunger are held in an open position within the anti-scald cavity with a bias spring. When the temperature of the mixed water reaches a pre¬set temperature in the sensing region of the anti-scald cavity, the thermal actuator is configured to expand such that the thermal actuator moves the plunger of the anti-scald device along the longitudinal axis of the anti-scald cavity to a closed position to close off the hot water inlet.

Abstract: A thermoplastic rough-in body for a wall-mount faucet, comprising a cold water inlet configured to fluidly couple to a cold water source and a hot water inlet configured to fluidly couple to a hot water source; a first chamber configured to receive a first handle/cartridge assembly and a second chamber configured to receive a second handle/cartridge assembly; an outlet configured to fluidly couple to a faucet spout assembly; a cold water flow channel, a hot water flow channel, and a mixing chamber.

Abstract: The tire (10) comprises a crown (12), two sidewalls (30A, 30B), two beads (32A, 32B), an inner surface (33) delimiting a toroidal cavity (35), and a stiffening structure (50) comprising a stiffening element (52) extending continuously into the toroidal cavity (35) from at least one of the sidewalls (30A, 30B) or one of the beads (32A, 32B) to the crown (12). The stiffening element (52) is anchored in or around: a radially inner reinforcing structure (60A, 60B) arranged in the sidewall (30A, 30B) and/or the bead (32A, 32B), the radially inner reinforcing structure (60A, 60B) being distinct from the circumferential reinforcing element (40A, 40B) situated on the same side of the median plane (M) of the tire (10) as the sidewall (30A, 30B) and/or the bead (32A, 32B), and a radially outer reinforcing structure (70A, 70B) arranged in the crown (12).

Abstract: A genomic data analyzer system method to analyze next generation sequencing genomic data from a sourcing laboratory. The method includes receiving, with a processor, a next generation sequencing analysis request from a sourcing laboratory, the next generation sequencing request comprising at least a raw next generation sequencing data file and the sourcing laboratory identification; identifying, with a processor, a first set of characteristics associated with the next generation sequencing analysis request, the first set of characteristics comprising at least a target enrichment technology identifier, a sequencing technology identifier, and a genomic context identifier; configuring, with a processor, a data alignment module to align the input raw sequencing data file in accordance with at least one characteristic of said first set of characteristics; and aligning, with the data alignment module processor, the input sequencing data to a genomic sequence.

Abstract: Disclosed herein are methods of reducing collagenase-mediated bruising in a subject having cellulite, methods of treating cellulite in a subject, and collagenase-containing formulations.