Abstract: Disclosed herein are methods of treating plantar fibromatosis in a subject or a population of subjects.

Abstract: The tire (10) has a stiffening structure (50) comprising a stiffening element (52, 53) anchored in or around radially inner reinforcing structures (60A) and a radially outer reinforcing structure (70A, 70B). Each stiffening element (52, 53) extending from one of the radially inner reinforcing structures (60A) comprises a portion (523) extending in the toroidal cavity (35) between first anchor points. Each stiffening element (52, 53) extending from the other of the radially inner reinforcing structures (60B) comprises a portion (524) extending in the toroidal cavity (35) between second anchor points. The portions (523) do not cross over in the toroidal cavity (35). The first anchor points are axially on the other side of the same side of the median plane (M) of the tire (10) as the second anchor points.

Abstract: A genomic data analyzer workflow may be configured to identify, with a variant annotation module, subsets of patient variants which match at least one medical reference variant database entry, even if the variant calling information in genomic data analyzer workflow and the database use different variant representations of SNP, MNP, INDELS and DELINS. In particular, database variants which are included into a subset of patient variants may be identified even if they do not exactly match the corresponding strings. The variant annotation module may be adapted to apply a branch-and-bound-like algorithm to efficiently process all possible subsets of patient variants in a genomic region.

Abstract: Method and systems for determining when to accelerate, decelerate, or maintain current speed of cruise control based on the blindspots of vehicles. Distances between a vehicle and one or more surrounding vehicles are measured using a plurality of sensors. These measurements are used to determine if a vehicle has a surrounding vehicle in its blindspot or if the vehicle is in the blindspot of the surrounding vehicle. Cost calculations are made to determine the individual cost calculations of maintaining current speed versus changing the acceleration. The lowest cost calculation is selected and implemented by the vehicle such that velocity is maintained or acceleration of the vehicle is changed.

Abstract: The tire (10) comprises a crown (12), two sidewalls (30A, 30B), two beads (32A, 32B), an inner surface (33) delimiting a toroidal cavity (35), and a stiffening structure (50) comprising a stiffening element (52) extending continuously into the toroidal cavity (35) from at least one of the sidewalls (30A, 30B) or one of the beads (32A, 32B) to the crown (12). The stiffening element (52) is anchored in or around: a radially inner reinforcing structure (60A, 60B) arranged in the sidewall (30A, 30B) and/or the bead (32A, 32B), the radially inner reinforcing structure (60A, 60B) being distinct from the circumferential reinforcing element (40A, 40B) situated on the same side of the median plane (M) of the tire (10) as the sidewall (30A, 30B) and/or the bead (32A, 32B), and a radially outer reinforcing structure (70A, 70B) arranged in the crown (12).

Abstract: A mouthpiece has an upper guard having a first mold layer and a first shell layer. The upper guard has an arcuate shape between a first end on a first side and a second end on a second side. The mouthpiece also has a lower guard having a second mold layer and a second shell layer. The lower guard has arcuate shape between a third end on a third side and a fourth end on a fourth side. Connectors couple the ends of the upper guard to the ends of the lower guard. The first and second mold layer are a flexible material and the first and second shell layer are a relatively rigid material.

Abstract: The tire (10) has a stiffening structure (50) comprising a stiffening element (52, 53) anchored in or around radially inner reinforcing structures (60A) and a radially outer reinforcing structure (70A, 70B). Each stiffening element (52, 53) extending from one of the radially inner reinforcing structures (60A) comprises a portion (523) extending in the toroidal cavity (35) between first anchor points. Each stiffening element (52, 53) extending from the other of the radially inner reinforcing structures (60B) comprises a portion (524) extending in the toroidal cavity (35) between second anchor points. The portions (523) do not cross over in the toroidal cavity (35). The first anchor points are axially on the other side of the same side of the median plane (M) of the tire (10) as the second anchor points.

Abstract: Tracking farm vehicle performance is provided. A system receives a data file comprising geospatial coordinates for a geographic area. The system identifies rows in the geographic area to associate with the geospatial coordinates. The system receives, from a sensor of a vehicle located in the geographic area, a first location point. The system determines, based on a comparison of the first location point and the geospatial coordinates associated with the rows, scores corresponding to a likelihood that the first location point is in each of the rows. The system provides an indication that the vehicle performed an activity on at least a portion of a first row of in the geographic area based on the scores.

Abstract: Resin compositions are provided for producing a three-dimensional object by additive manufacturing that include at least one reactive compound having a filler moiety covalently attached (bonded) thereto. In some embodiments, the reactive compound may be a monomer, a prepolymer, a chain extender, and/or a reactive diluent. In certain embodiments, more than one type of reactive compound may include a filler moiety covalently attached thereto.

Abstract: A mouthpiece has an upper guard having a first mold layer and a first shell layer. The upper guard has an arcuate shape between a first end on a first side and a second end on a second side. The mouthpiece also has a lower guard having a second mold layer and a second shell layer. The lower guard has arcuate shape between a third end on a third side and a fourth end on a fourth side. Connectors couple the ends of the upper guard to the ends of the lower guard. The first and second mold layer are a flexible material and the first and second shell layer are a relatively rigid material.

Abstract: According to some embodiments, a skin treatment system comprises a manifold assembly comprising at least one fluid connector to secure at least one treatment fluid container, a primary handpiece configured to hydraulically couple to the manifold assembly, wherein the primary handpiece is hydraulically coupled to the manifold assembly using at least one fluid conduit, and a flow control device positioned along the at least one fluid conduit, the flow control device configured to switch flow of treatment fluid from the at least one treatment fluid between the primary handpiece and a port, wherein the port is configured to be coupled to a secondary handpiece, wherein a vacuum source is configured to operatively couple to the system and selectively create suction along the primary handpiece.

Abstract: A cake covering assembly for protecting a cake from airborne pathogens includes a cover that is positionable over a cake. The cover is comprised of a fluid impermeable material to protect the cake from airborne pathogens. The cover has a plurality of candle openings each extending through the cover. A plurality of candle holders is provided and each of the candle holders has a receiver to insertably receive a candle. Each of the candle holders is insertable through a respective one of the candle openings having the receiver being spaced above the cover. In this way each of the candle holders can support the candle in a vertical orientation thereby facilitating the candle to be blown out by a user in the convention of blowing out birthday candles.

Abstract: A genomic data analyzer system method to analyze next generation sequencing genomic data from a sourcing laboratory. The method includes receiving, with a processor, a next generation sequencing analysis request from a sourcing laboratory, the next generation sequencing request comprising at least a raw next generation sequencing data file and the sourcing laboratory identification; identifying, with a processor, a first set of characteristics associated with the next generation sequencing analysis request, the first set of characteristics comprising at least a target enrichment technology identifier, a sequencing technology identifier, and a genomic context identifier; configuring, with a processor, a data alignment module to align the input raw sequencing data file in accordance with at least one characteristic of said first set of characteristics; and aligning, with the data alignment module processor, the input sequencing data to a genomic sequence.

Abstract: Method and systems for determining when to accelerate, decelerate, or maintain current speed of cruise control based on the blindspots of vehicles. Distances between a vehicle and one or more surrounding vehicles are measured using a plurality of sensors. These measurements are used to determine if a vehicle has a surrounding vehicle in its blindspot or if the vehicle is in the blindspot of the surrounding vehicle. Cost calculations are made to determine the individual cost calculations of maintaining current speed versus changing the acceleration. The lowest cost calculation is selected and implemented by the vehicle such that velocity is maintained or acceleration of the vehicle is changed.

Abstract: The tire (10) comprises a crown (12), two sidewalls (30A, 30B), two beads (32A, 32B), an inner surface (33) delimiting a toroidal cavity (35), and a stiffening structure (50) comprising a stiffening element (52) extending continuously into the toroidal cavity (35) from at least one of the sidewalls (30A, 30B) or one of the beads (32A, 32B) to the crown (12). The stiffening element (52) is anchored in or around: a radially inner reinforcing structure (60A, 60B) arranged in the sidewall (30A, 30B) and/or the bead (32A, 32B), the radially inner reinforcing structure (60A, 60B) being distinct from the circumferential reinforcing element (40A, 40B) situated on the same side of the median plane (M) of the tire (10) as the sidewall (30A, 30B) and/or the bead (32A, 32B), and a radially outer reinforcing structure (70A, 70B) arranged in the crown (12).

Abstract: A genomic data analyzer system method to analyze next generation sequencing genomic data from a sourcing laboratory. The method includes receiving, with a processor, a next generation sequencing analysis request from a sourcing laboratory, the next generation sequencing request comprising at least a raw next generation sequencing data file and the sourcing laboratory identification; identifying, with a processor, a first set of characteristics associated with the next generation sequencing analysis request, the first set of characteristics comprising at least a target enrichment technology identifier, a sequencing technology identifier, and a genomic context identifier; configuring, with a processor, a data alignment module to align the input raw sequencing data file in accordance with at least one characteristic of said first set of characteristics; and aligning, with the data alignment module processor, the input sequencing data to a genomic sequence.

Abstract: Disclosed herein are methods of reducing collagenase-mediated bruising in a subject having cellulite, methods of treating cellulite in a subject, and collagenase-containing formulations.

Abstract: An omnidirectional locomotion system that can be used with virtual reality (VR) environment technology includes at least a base portion, an articulating arm extending upward from a platform of the base portion, and a rotation mechanism rotatably coupling the base portion to the articulating arm. The platform of the base portion is configured to support a user and the articulating arm can include a harness support configured to attach to a harness worn by the user. The articulating arm comprises at least a first link, a second link, and a hinged joint coupled between the first link and the second link. The rotation mechanism can permit the articulating arm to rotate through 360-degrees around an outer circumference of the base portion; the hinged join can permit the articulating arm to translate horizontally or vertically with respect to the base portion.

Abstract: An apparatus for forming an anchor to connect a fiber to an explosive charge wall includes an anchor insert tab disposed on the interior side of the wall, a top plate disposed on the exterior side of the wall, an ST connector disposed on the exterior side and attached to the top plate to position the ST connector at the fiber insert wall opening for receiving the fiber, a plurality of zip ties extending through the anchor insert tab, the wall, and the top plate, and a plurality of locking members one for each of the zip ties. The zip ties each have a locking head disposed on the interior side of the wall to press the anchor insert tab against the interior wall surface. The locking members are engaged with the zip ties to press the top plate against the exterior wall surface to form the anchor.