Abstract: The present disclosure relates to methods and systems that provide a framework for accelerating the development of large language models (LLM)s solutions. The present disclosure provides methods and systems that support a complete cycle for developing LLM solutions, testing the LLM solutions, deploying the LLM solutions, and providing feedback on the deployed LLM solutions.

Abstract: The present technology is generally directed to methods for addressing a patient's sleep apnea. At least some of the methods can include one or more of percutaneously inserting an implantable signal delivery device at an insertion point on the patient's neck, moving the signal delivery device in a medial-to-lateral direction toward an ansa cervicalis nerve of the patient, and implanting the signal delivery device at a target location at least proximate to the ansa cervicalis nerve. The signal delivery device can include at least one electrode positioned to deliver a modulation signal to tissue at least proximate to the target location, such as a portion of the ansa cervicalis nerve. In some embodiments, delivery of the modulation signal can induce caudal traction in the patient and thereby address the patient's sleep apnea.

Abstract: The present technology is generally directed to systems and methods for addressing a patient's sleep apnea. At least some embodiments include an electrode array and a controller. The electrode array can include one or more electrodes and can be configured to be implanted at least proximate to a target tissue of the patient in an orientation, with at least a vector component of the orientation aligned along an inferior-superior axis of the patient. The controller can be communicatively coupled to the electrode array and include one or more non-transitory, computer-readable media having instructions that, when executed by one or more processors of the controller, cause the controller to direct an electrical signal to be delivered by the electrode array to the target tissue.

Abstract: The present technology is generally directed to systems and methods for addressing a patient's sleep apnea. At least some embodiments include an electrode array and a controller. The electrode array can include one or more electrodes and can be configured to be implanted at least proximate to a target tissue of the patient in an orientation, with at least a vector component of the orientation aligned along an inferior-superior axis of the patient. The controller can be communicatively coupled to the electrode array and include one or more non-transitory, computer-readable media having instructions that, when executed by one or more processors of the controller, cause the controller to direct an electrical signal to be delivered by the electrode array to the target tissue.

Abstract: Intraoral appliances are disclosed that provide electrical stimulation to tissue in a patient's oral cavity in a manner that reduces apnea events during sleep. A representative appliance can induce a current or currents through tissue and/or anatomical structures in a manner that maintains upper airway tone and/or patency.

Abstract: The present technology is generally directed to wearable devices for treating sleep apnea, and associated systems and methods. In some embodiments, a system for treating sleep apnea comprises an implantable device and a wearable device. The implantable device can be implantably positionable at a patient's head and/or neck, proximate to the patient's oral cavity, and include a signal generator configured to generate an electrical signal, an electrode coupled to the signal generator to direct the electrical signal to the patient's tissue, and a power receiver device coupled to the signal generator. The wearable device can include a power source and a power transmission device coupled to the power source and configured to transmit power wirelessly to the implantable device.

Abstract: Intraoral electrical stimulation devices are disclosed. A representative device, which can be used to treat sleep apnea, includes an intraoral attachment body, a guide element carried by the attachment body and having a constrained guide path, and an electrode movably supported relative to the guide element and movable along the constrained guide path to a plurality of positions. A positioning member is coupleable to the electrode to move the electrode along the constrained guide path, and a signal generator is coupleable to the electrode to direct a stimulation signal to the electrode.

Abstract: Intraoral electrical stimulation devices are disclosed. A representative device, which can be used to treat sleep apnea, includes an intraoral attachment body, a guide element carried by the attachment body and having a constrained guide path, and an electrode movably supported relative to the guide element and movable along the constrained guide path to a plurality of positions. A positioning member is coupleable to the electrode to move the electrode along the constrained guide path, and a signal generator is coupleable to the electrode to direct a stimulation signal to the electrode.

Abstract: Intraoral appliances are disclosed that provide electrical stimulation to tissue in a patient's oral cavity in a manner that reduces apnea events during sleep. A representative appliance can induce a current or currents through tissue and/or anatomical structures in a manner that maintains upper airway tone and/or patency.

Abstract: The invention includes an attachment for a socket wrench that is capable of imparting torque about an axis simultaneously in opposite directions. The invention also includes a method for imparting torque about an axis simultaneously in opposite directions.

Abstract: This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.

Abstract: This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

Abstract: There is disclosed a wrapper for a smoking article, the wrapper comprising a single paper sheet. The sheet is formed from at least two webs. The webs are combined whilst at least one web is still in its wet stage of production prior to drying. Different stocks can be used to make the webs so as to impart different qualities.

Abstract: A smoking device for releasing an aerosol into the mouth of a smoker comprises in combination, a chamber into which a mixture of air and a liquid aerosol precursor is introduced, a heat source surrounding the chamber, a first duct providing communication between the chamber and a smoker's mouth, whereby the contents of the chamber may be drawn into the smoker's mouth, a container for the aerosol precursor, a second duct means leading from the aerosol precursor container into the chamber whereby aerosol precursor may pass from said container into the chamber, and a third duct means providing communication between ambient air and the chamber whereby ambient air may be drawn into the chamber by the smoker, the arrangement being such that in operation liquid aerosol precursor entering the chamber is converted into a condensation aerosol.