Abstract: The application relates to a compound of formula (I) containing a thiazole ring, an indazol ring and a 6,7-dihydro-5H-pyrrolo[1,2-c]imidazole ring system, to pharmaceutical compositions containing it and its medical use. The compounds are described as selective allosteric inhibitors of T790M/L858R, T790M/L858R/C797S, L858R, L858R/C797S containing EGFR mutants and thus useful for the treatment of cancer, in particular non-small cell lung cancer.

Abstract: The invention provides novel compounds as described herein, compositions including the compounds and methods of using the compounds.

Abstract: The invention provides novel a compound having the general formula (I) as described herein, compositions including the compound and methods of using the compound.

Abstract: A butt stock for a firearm including the butt stock arrangeable in a first configuration to fold toward a first side of a receiver of the firearm into a first folded position along the first side of the receiver, and unfoldable away from the first side of the receiver of the firearm into an unfolded position rearward of the receiver; and the butt stock arrangeable in a second configuration to fold toward a second side of the receiver of the firearm into a second folded position along the second side of the receiver, and unfoldable away from the second side of the receiver of the firearm into the unfolded position rearward of the receiver.

Abstract: A butt stock for a firearm including the butt stock arrangeable in a first configuration to fold toward a first side of a receiver of the firearm into a first folded position along the first side of the receiver, and unfoldable away from the first side of the receiver of the firearm into an unfolded position rearward of the receiver; and the butt stock arrangeable in a second configuration to fold toward a second side of the receiver of the firearm into a second folded position along the second side of the receiver, and unfoldable away from the second side of the receiver of the firearm into the unfolded position rearward of the receiver.

Abstract: A firearm comprising a barrel, a handguard disposed around the barrel; a manually operated pump-action reload mechanism, the pump-action reload mechanism comprising a hand-held actuation arrangement and a fore-end body, the fore-end body disposed around the barrel between the handguard and the barrel, and the hand-held actuation arrangement coupled to the fore-end body to operate the pump-action reload mechanism. In addition, or alternatively, the firearm may include a bolt carrier locking mechanism and/or a butt stock that may be folded on either side of the receiver.

Abstract: A hand guard comprising a hand guard body; a plurality of keys formed in the hand guard body, each of the keys comprising a hole portion and a slot portion intersecting the hole portion; each of the keys have a longitudinal axis; and each of the keys are arranged with the longitudinal axis of each of the keys extending around a circumference of the hand guard body.

Abstract: A firearm comprising a barrel, a handguard disposed around the barrel; a manually operated pump-action reload mechanism, the pump-action reload mechanism comprising a hand-held actuation arrangement and a fore-end body, the fore-end body disposed around the barrel between the handguard and the barrel, and the hand-held actuation arrangement coupled to the fore-end body to operate the pump-action reload mechanism. In addition, or alternatively, the firearm may include a bolt carrier locking mechanism and/or a butt stock that may be folded on either side of the receiver.

Abstract: A tree chipper capable of reducing standing trees to chips has a rotating chipper, a feed mechanism for feeding trees into the chipper and a saw or the like for severing the trees. The tree chipper may comprise a boom that can be moved to position the tree chipper against a tree to be cut and chipped. In embodiments, the rotating chipper comprises a disc having chipping teeth on a face, a generally cylindrical chipper body having chipping teeth on an outer surface thereof and a conical chipper body.

Abstract: A radiation-cured, elastomeric, urethane acrylate polymer has an elongation at break of between 100% (50) and 400% and a film break strength of between 200 and 2,600 psi at a thickness between about 0.002 inches and 0.010 inches.

Abstract: Techniques for adhering metal backed cube corner Retroreflective tapes to a variety of fabric types, such as Gortex™, by applying a thermoset adhesive to the back of the tape at temperatures below the activation temperature (e.g., at about the melt temperature), and then subsequently applying the tape to the garment at temperatures above the adhesive activation temperature. This permits adhesive bonding to both the fabric and the tape at the same time, which in turn provides improved performance through numerous wash and wear cycles.

Abstract: A cable tie with a flexible strap having an elongated section defining a longitudinal axis, the strap having a head end, a tail end, a top side and a lower side, the lower side defining a plurality of longitudinally spaced apart teeth extending transversely to the longitudinal axis. The tie also has a head defining a channel defined by side and top walls and adapted to receive the strap, and a latch adapted to engage with one or more teeth of the strap, to retain the strap in the head. There are a series of visible markings spaced along the top side of the strap. These markings indicate the diameter of the engaged strap.

Abstract: A cable tie with an elongated tongue with two ends and two broad sides, a tip at one end of the tongue, a set of ratchet teeth extending along one broad side of the tongue, and a locking head at the other end of the tongue, the locking head having sides defining an opening for receiving the tip of the tongue, and a movable pawl that is hinged at one side of the opening, with another side of the opening defining an abutment wall that is across the opening from the pawl. The pawl engages with one or more of the ratchet teeth when the tongue has been inserted through the opening with the set of ratchet teeth facing the pawl. The abutment wall defines at least one protruding cross member, to strengthen the abutment wall.

Abstract: A cable tie having an elongated tongue with two ends and two broad sides, a tip at one end of the tongue, a set of ratchet teeth extending along at least one broad side of the tongue, and a locking head at the other end of the tongue. The locking head has sides defining an opening for receiving the tip of the tongue, and a movable pawl that is hinged at one side of the opening, with another side of the locking head defining an abutment wall that is across the opening from the pawl. The pawl engages with one or more of the ratchet teeth when the tongue has been inserted through the opening with the set of ratchet teeth facing the pawl. At least one other side of the locking head defines a thinned region that can be torn by the user to release the tongue from the head.