Abstract: The present disclosure provides mammalian cell lines for expression of viral vectors, and methods of making and using the same. Provided methods employ use of identifiers that are capable of being packaged into a viral vector to select and/or identify mammalian cell lines with engineered sequences associated with beneficial characteristics for viral vectors production. Exemplary viral vectors include AAV vectors.

Abstract: A voltage monitoring system and a method for harvesting energy is disclosed. A system includes a ring oscillator circuit, which incorporates delay line circuit composed of series of inverting logic gates. The final inverting logic gate forms self-oscillating feedback loop by connecting its output to the input of the first logic gate. To interface with ring oscillator circuit, transistor-based voltage divider circuit is implemented. The transistor-based voltage divider circuit utilizes multiple diode-connected transistor devices, with bulk terminals interconnected to the respective source terminals. Enable signal controls final diode-connected transistor device at its gate terminal. Furthermore, a voltage-level shifter circuit is connected to output of inverting logic gates, enabling seamless integration with ring oscillator circuit. Finally, a counter circuit is linked to voltage-level shifter circuit, utilizing its output terminal.

Abstract: A charging circuit for a capacitor in a defibrillator includes a control enabling a setting of a desired time to charge a capacitor to a desired voltage in the defibrillator. The charging circuit further includes a flyback charge-pump circuit comprising a switch, an energy transfer transformer, an energy storage capacitor and a control. The switch is configured to stop or allow storage of energy in a transformer. The transformer transfers the energy to the capacitor. The flyback charge-pump circuit controls a duty-cycle on the switch so that a current draw from a power source (e.g. battery) is sufficient to enable charging the capacitor to the desired voltage within the desired time set on the control.

Abstract: A network, such as a hybrid fiber-coaxial (HFC) network, may comprise a plurality of nodes. Each node may facilitate transmission of service signals between a service provider and a plurality of subscribers. If a node's utilization is determined to be above a predetermined threshold that is indicative of congestion on the node, a system associated with the service provider and/or a third party service may identify a subset of subscribers with excessive data usage. For example, the system may receive usage data for each subscriber serviced by the node, and compare the usage data to a total usage data among the subscribers serviced by the node and/or a standard to identify the subset. Once identified, the system may determine a cause of the excessive data usage for each subscriber within the subset, and determine an action to be performed based on the cause to alleviate the congestion on the node.

Abstract: Systems, methods, and computer readable media for power outage determination. A device may determine an indication that an outage has occurred on a cable network based on a status of a network device within the cable network, wherein the network device receives power from a power network. The device may determine location information for at least a portion of a plurality of network devices, including the network device, within the cable network. The device may determine a cable topology of the cable network at an area that includes a location that corresponds to the network device. The device may determine a power topology of the power network at the area. The device may analyze the cable topology and the power topology at the area. The device may identify one or more potential failure locations on the power network.

Abstract: Disclosed are methods and systems that make use of light scattering techniques, such as the use of a multiphoton laser-scanning microscope, to quantify the scattering directionality of second harmonic generation (SHG) from biopsy samples of cancer in order to predict efficacy of neoadjuvant chemotherapy.

Abstract: Systems, methods, and computer readable media for power outage determination. A device may determine an indication that an outage has occurred on a cable network based on a status of a network device within the cable network, wherein the network device receives power from a power network. The device may determine location information for at least a portion of a plurality of network devices, including the network device, within the cable network. The device may determine a cable topology of the cable network at an area that includes a location that corresponds to the network device. The device may determine a power topology of the power network at the area. The device may analyze the cable topology and the power topology at the area. The device may identify one or more potential failure locations on the power network.

Abstract: Disclosed are methods and compositions for early diagnosis, monitoring and treatment of an ocular disorder. In particular, the invention relates to a novel protein, that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with healthy subjects, antibodies which recognize this protein, and methods for diagnosing such conditions.

Abstract: Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with nonsufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.

Abstract: A dry fire protection system for a water heater is provided. The water heater includes a body having an elongated hollow for holding water to be heated, an inlet opening and an outlet opening in communication with the hollow for flowing water therethrough. A heating element is coupled to the body for heating the water within the hollow. The dry fire protection system comprises a sensing element disposed in the hollow of the body for detecting the presence of water in the hollow. The sensing element is spaced from and operably connected to the heating element. The sensing element is configured to generate a voltage in response to a temperature of the sensing element. A controller is operably connected to the sensing element for monitoring the generated voltage across the sensing element. The controller is configured to prevent a supply of electrical power to the heating element as a function of the generated voltage.

Abstract: Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with nonsufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.

Abstract: Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with nonsufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.

Abstract: Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with nonsufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.

Abstract: Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with nonsufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.

Abstract: Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with nonsufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.

Abstract: Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with non-sufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.

Abstract: Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, choroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed “Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with non-sufferers, antibodies which recognize this protein, and methods for diagnosing such conditions.

Abstract: Disclosed are methods and compositions for early diagnosis, monitoring and treatment of an ocular disorder. In particular, the invention relates to a novel protein, that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with healthy subjects, antibodies which recognize this protein, and methods for diagnosing such conditions.

Abstract: Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best disease, chroidema, gyrate atrophy, congenital amourosis, refsun syndrome, stargardt disease and Usher syndrome. In particular, the invention relates to a protein, termed 2Rdcvf1,” that is differentially transcribed and expressed in subjects suffering from retinal dystrophies and the like, such as retinal dystrophy and age-related macular degeneration compared with non-sufferers, antibodies which recongnize this protein, and methods for diagnosing such conditions.

Abstract: A dry fire protection system for a water heater is provided. The water heater includes a body having an elongated hollow for holding water to be heated, an inlet opening and an outlet opening in communication with the hollow for flowing water therethrough. A heating element is coupled to the body for heating the water within the hollow. The dry fire protection system comprises a sensing element disposed in the hollow of the body for detecting the presence of water in the hollow. The sensing element is spaced from and operably connected to the heating element. The sensing element is configured to generate a voltage in response to a temperature of the sensing element. A controller is operably connected to the sensing element for monitoring the generated voltage across the sensing element. The controller is configured to prevent a supply of electrical power to the heating element as a function of the generated voltage.