Abstract: Provided herein are methods of treating B7-H1-expressing tumors comprising administering an effective amount of MEDI4736 or an antigen-binding fragment thereof.

Abstract: According to at least one embodiment, an electric actuator for a marine steering system is disclosed. The electric actuator includes a housing, an output shaft, a screw assembly coupled to the output shaft, a rotor coupled to the screw assembly, and a motor configured to rotate the rotor. Rotation of the rotor causes the output shaft to translate axially relative to the housing.

Abstract: The propulsion unit comprises an electric actuator and a tiller coupled the electric actuator. The electric actuator includes a housing having a first end and second end. There is an output shaft fully received within the housing. The output shaft includes a coupling portion and a tiller is coupled the coupling portion of the output shaft such that such that a line of action of the actuator is in the same plane as the tiller.

Abstract: A steering system for a marine vessel comprises a helm, a control head, and a joystick. The helm and control head may respectively provide user inputted steering commands and user inputted shift and throttle commands on a first CAN network. The joystick and the control head may respectively provide user inputted steering commands and user inputted shift and throttle commands on a second CAN network. The helm may provide user inputted steering commands on the first CAN network. The control head may provide user inputted shift and throttle commands on the second CAN network. The joystick may provide user inputted steering commands and user inputted shift and throttle commands on either the first CAN network or the second CAN network.

Abstract: A steering system for a marine vessel comprises a helm, a control head, and a joystick. The helm and control head may respectively provide user inputted steering commands and user inputted shift and throttle commands on a first CAN network. The joystick and the control head may respectively provide user inputted steering commands and user inputted shift and throttle commands on a second CAN network. The helm may provide user inputted steering commands on the first CAN network. The control head may provide user inputted shift and throttle commands on the second CAN network. The joystick may provide user inputted steering commands and user inputted shift and throttle commands on either the first CAN network or the second CAN network.

Abstract: In one embodiment the invention is a hand guard, comprising: a generally hollow cylindrical body having a rail securing top surface; a top Picatinny rail securable to the rail securing top surface. The top rail is in slidable engagement with the rail securing top surface such that the top Picatinny rail is removable from the top surface. The generally hollow cylindrical body is populated with vent holes. In another embodiment an upper receiver is provided, the upper receiver includes a front face located at a front end of the upper receiver, the upper receiver having a Picatinny rail atop thereof, the Picatinny rail having a last rail located at a front end of the Picatinny rail, the last rail is aligned with the front face. In another embodiment the hand guard has a fixed Picatinny rail atop thereof. At least one plug is optionally provided for fitting into vent holes.

Abstract: A steering system for a marine vessel comprises a helm, a control head, and a joystick. The helm and control head may respectively provide user inputted steering commands and user inputted shift and throttle commands on a first CAN network. The joystick and the control head may respectively provide user inputted steering commands and user inputted shift and throttle commands on a second CAN network. The helm may provide user inputted steering commands on the first CAN network. The control head may provide user inputted shift and throttle commands on the second CAN network. The joystick may provide user inputted steering commands and user inputted shift and throttle commands on either the first CAN network or the second CAN network.

Abstract: In one embodiment the invention is a hand guard, comprising: a generally hollow cylindrical body having a rail securing top surface; a top Picatinny rail securable to the rail securing top surface. The top rail is in slidable engagement with the rail securing top surface such that the top Picatinny rail is removable from the top surface. The generally hollow cylindrical body is populated with vent holes. In another embodiment an upper receiver is provided, the upper receiver includes a front face located at a front end of the upper receiver, the upper receiver having a Picatinny rail atop thereof, the Picatinny rail having a last rail located at a front end of the Picatinny rail, the last rail is aligned with the front face. In another embodiment the hand guard has a fixed Picatinny rail atop thereof. At least one plug is optionally provided for fitting into vent holes.

Abstract: A steering system for a marine vessel comprises a helm, a control head, and a joystick. The helm and control head may respectively provide user inputted steering commands and user inputted shift and throttle commands on a first CAN network. The joystick and the control head may respectively provide user inputted steering commands and user inputted shift and throttle commands on a second CAN network. The helm may provide user inputted steering commands on the first CAN network. The control head may provide user inputted shift and throttle commands on the second CAN network. The joystick may provide user inputted steering commands and user inputted shift and throttle commands on either the first CAN network or the second CAN network.

Abstract: A steering system for a marine vessel comprises a helm, a control head, and a joystick. The helm and control head may respectively provide user inputted steering commands and user inputted shift and throttle commands on a first CAN network. The joystick and the control head may respectively provide user inputted steering commands and user inputted shift and throttle commands on a second CAN network. The helm may provide user inputted steering commands on the first CAN network. The control head may provide user inputted shift and throttle commands on the second CAN network. The joystick may provide user inputted steering commands and user inputted shift and throttle commands on either the first CAN network or the second CAN network.

Abstract: A steering apparatus comprises a rotatable steering shaft and a sensor which senses angular movement of the steering shaft. An electromagnetic actuator actuates a stop mechanism to releasable engage the steering shaft. There is a microcontroller which causes the electromagnetic actuator to actuate the stop mechanism to fully engage the steering shaft and prevent rotation of the steering shaft in a first rotational direction, which corresponds to movement towards the hardstop position, while allowing rotational play between the steering shaft and the stop mechanism in a second direction, which corresponds to rotational movement away from the hardstop position, when the sensor senses that the steering shaft has reached a hardstop position. A driver applies a reserve polarity pulse to the electromagnetic actuator when the stop mechanism is fully engaged and the steering shaft is rotated, as permitted by the rotational play, in the second rotational direction.

Abstract: A steering apparatus comprises a rotatable steering shaft and a sensor which senses angular movement of the steering shaft. An electromagnetic actuator actuates a stop mechanism to releasable engage the steering shaft. There is a microcontroller which causes the electromagnetic actuator to actuate the stop mechanism to fully engage the steering shaft and prevent rotation of the steering shaft in a first rotational direction, which corresponds to movement towards the hardstop position, while allowing rotational play between the steering shaft and the stop mechanism in a second direction, which corresponds to rotational movement away from the hardstop position, when the sensor senses that the steering shaft has reached a hardstop position. A driver applies a reserve polarity pulse to the electromagnetic actuator when the stop mechanism is fully engaged and the steering shaft is rotated, as permitted by the rotational play, in the second rotational direction.

Abstract: A steering system for a marine vessel comprises a helm, a control head, and a joystick. The helm and control head may respectively provide user inputted steering commands and user inputted shift and throttle commands on a first CAN network. The joystick and the control head may respectively provide user inputted steering commands and user inputted shift and throttle commands on a second CAN network. The helm may provide user inputted steering commands on the first CAN network. The control head may provide user inputted shift and throttle commands on the second CAN network. The joystick may provide user inputted steering commands and user inputted shift and throttle commands on either the first CAN network or the second CAN network.

Abstract: A process for preparation of nutritionally upgraded oilseed meals which are protein and lipid-rich and have a reduced fibre content, and plant oils from oilseeds for use in fish or other non-human animal diets or human foods comprising the steps of: providing a source of oilseed; subjecting the oilseed to heat treatment to substantially reduce the concentration of at least some antinutritional components normally present in the oilseed to obtain heat-treated seed; dehulling the heat-treated seed to produce a meat fraction, a hull fraction or a mixture thereof; and cold pressing the meat fraction or the mixture to yeild the plant oils and the protein and lipid-rich meals.

Abstract: A process for preparation of nutritionally upgraded oilseed meals which are protein and lipid-rich and have a reduced fiber content, and plant oils from oilseeds for use in fish or other non-human animal diets or human foods comprising the steps of: providing a source of oilseed; subjecting the oilseed to heat treatment to substantially reduce the concentration of at least some antinutritional components normally present in the oilseed to obtain heat-treated seed; dehulling the heat-treated seed to produce a meat fraction, a hull fraction or a mixture thereof; and cold pressing the meat fraction or the mixture to yeild the plant oils and the protein and lipid-rich meals.

Abstract: A process for preparation of nutritionally upgraded oilseed meals which are protein and lipid-rich and have a reduced fiber content, and plant oils from oilseeds for use in fish or other non-human animal diets or human foods comprising the steps of: providing a source of oilseed; subjecting the oilseed to heat treatment to substantially reduce the concentration of at least some antinutritional components normally present in the oilseed to obtain heat-treated seed; dehulling the heat-treated seed to produce a meat fraction, a hull fraction or a mixture thereof; and cold pressing the meat fraction or the mixture to yeild the plant oils and the protein and lipid-rich meals.

Abstract: An apparatus comprising three main assemblies, an applicator, an infusion/aspiration tube with a subcutaneous bone penetration means, and a strain relief protector. The apparatus enables a user in field or emergency environments to quickly, safely and reliably place an infusion/aspiration device in a patient's bone, regardless of the thickness of skin and tissue over the bone, and to ensure it will remain in place throughout other emergency procedures and severe environmental conditions. The infusion/aspiration apparatus incorporates a bone stop to ensure precise location of the bone penetration means at the intended marrow depth in the patient's bone.