Patents by Inventor David HILE

David HILE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Buffers for Controlling the pH of Bone Morphogenetic Proteins
    Publication number: 20130172254
    Abstract: The present invention provides formulations of cysteine knot proteins, including TGF-? superfamily proteins and bone morphogenic proteins that are pH stabilized. In particular, the present invention relates to the observation that certain buffers enhance the stability of cysteine knot proteins, including TGF-? superfamily proteins and bone morphogenic proteins. In particular, disclosed herein are liquid and lyophilized formulations prepared with a glycylglycine and tartaric acid buffers to stabilize the pH of the formulation.
    Type: Application
    Filed: September 14, 2012
    Publication date: July 4, 2013
    Applicant: STRYKER CORPORATION
    Inventors: David Hile, Gregg Strohmeier
  • Buffers for Controlling the pH of Bone Morphogenetic Proteins
    Publication number: 20110224410
    Abstract: The present invention provides formulations of cysteine knot proteins, including TGF-? superfamily proteins and bone morphogenic proteins that are pH stabilized. In particular, the present invention relates to the observation that certain buffers enhance the stability of cysteine knot proteins, including TGF-? superfamily proteins and bone morphogenic proteins. In particular, disclosed herein are liquid and lyophilized formulations prepared with a glycylglycine and tartaric acid buffers to stabilize the pH of the formulation.
    Type: Application
    Filed: September 17, 2010
    Publication date: September 15, 2011
    Inventors: David HILE, Gregg STROHMEIER