Abstract: There is disclosed herein a device 1000 comprising: a lower lightbox 100; and an upper lightbox 300 arranged on top of the lower lightbox and connected thereto at one side by a hinge. The device may be operated as a clapperboard and may also function as a lightbox for providing direct or ambient lighting to its surroundings.

Abstract: Disclosed herein are instruments and methods for delivery of substrates, including cell-seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

Abstract: Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.

Abstract: There is disclosed herein a device 1000 comprising: a lower lightbox 100; and an upper lightbox 300 arranged on top of the lower lightbox and connected thereto at one side by a hinge. The device may be operated as a clapperboard and may also function as a lightbox for providing direct or ambient lighting to its surroundings.

Abstract: The production of high quality retinal pigmented epithelium (RPE) cells is necessary for research and potential therapeutic uses. Especially desirable are methods for the production of RPE cells using xeno-free culture conditions. Disclosed herein are novel methods for the production of RPE cells from pluripotent cells with high yields, including xeno-free production methods. Also provided are methods of efficiently isolating RPE cells from cultures containing heterogeneous cell types, allowing for substantially pure RPE cell cultures to be established. Additionally, novel methods for the cryopreservation of RPE cells are provided.

Abstract: The production of high quality retinal pigmented epithelium (RPE) cells is necessary for research and potential therapeutic uses. Especially desirable are methods for the production of RPE cells using xeno-free culture conditions. Disclosed herein are novel methods for the production of RPE cells from pluripotent cells with high yields, including xeno-free production methods. Also provided are methods of efficiently isolating RPE cells from cultures containing heterogeneous cell types, allowing for substantially pure RPE cell cultures to be established. Additionally, novel methods for the cryopreservation of RPE cells are provided.

Abstract: Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.

Abstract: The invention relates to a geotextile that is treated with: a metal such as copper to prevent plant roots or microorganisms growing on and through the geotextile. The geotextile is used in conjunction with a subsurface fluid supply system, where the treated geotextile prevents the ingress of roots into drippers that are disposed on conduit of the fluid supply system.

Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

Abstract: Disclosed herein are instruments and methods for delivery of substrates, including cell-seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

Abstract: Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.

Abstract: The present application relates to a method and apparatus for digital data processing systems suitable for providing Internet browsing within a computer network. In particular, the present application provides a method of operating a data processing system. The method may include the step of operatively divesting the browsing of web sites from the central processing of applications. In another aspect, the present application provides a data processing system that may include: central processing means adapted to operate in accordance with a predetermined instruction set and an Internet browser function; the central processing means, in conjunction with the Internet browser function, being adapted to perform web browsing wherein the Internet browser function is operatively divested from the central processing means.

Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

Abstract: A method of treating ocular disorders (such as, for example, proliferative vitreoretinopathy or PVR) associated with replicating ocular cells by transfecting replicating ocular cells in vivo with a polynucleotide encoding an agent which is capable of providing for the inhibition, prevention, or destruction of the growth of the replicating ocular cells upon expression of the agent. The agent may be a viral thymidine kinase, and the polynucleotide encoding the agent may be contained in a retroviral vector. Once the replicating ocular cells are transduced with the retroviral vector, the patient is given a chemotherapeutic or interaction agent, such as ganciclovir, which kills the transfected replicating ocular cells.

Abstract: A method of treating ocular disorders (such as, for example, proliferative vitreoretinopathy or PVR) associated with replicating ocular cells by transfecting replicating ocular cells in vivo with a polynucleotide encoding an agent which is capable of providing for the inhibition, prevention, or destruction of the growth of the replicating ocular cells upon expression of the agent. The agent may be a viral thymidine kinase, and the polynucleotide encoding the agent may be contained in a retroviral vector. Once the replicating ocular cells are transduced with the retroviral vector, the patient is given a chemotherapeutic or interaction agent, such as ganciclovir, which kills the transfected replicating ocular cells.

Abstract: A traction assembly of a work machine having (i) a differential housing having an axle passageway extending therethrough and (ii) an axle positioned within the axle passageway is disclosed. The traction assembly includes a gear mechanically coupled to the axle. The gear includes (i) an outer peripheral surface having a plurality of sensor teeth defined therein, (ii) a first shoulder extending in a first lateral direction, and (iii) a second shoulder extending in a second direction. The traction assembly also includes a bearing assembly attached to the differential housing, wherein (i) the bearing assembly includes a first bearing member and a second bearing member, (ii) the gear is interposed between the first bearing member and the second bearing member, (iii) the first shoulder of the gear contacts a first journal surface of the first bearing member, and (iv) the second shoulder of the gear contacts a second journal surface of the second bearing member.

Abstract: An apparatus for controlling temperature of fluid in a differential assembly. The apparatus includes a differential housing having a number of sidewalls which collectively define an internal component chamber, wherein (i) the internal component chamber has a differential sump located therein, and (ii) the differential sump has a sump input port defined therein. The apparatus also includes a first operational pressure source which advances fluid from the internal component chamber of the differential housing. The apparatus further includes a diverter valve which receives fluid advanced by the first operational pressure source from the internal component chamber. The diverter valve has a cold fluid output port and a hot fluid output port. A heating fluid return line is interposed between the cold fluid output port of the diverter valve and the sump input port of the differential sump.

Abstract: A differential assembly which includes a differential housing is disclosed. The differential housing defines an internal component chamber, a fluid housing inlet, and a fluid housing outlet. The differential assembly also includes a spider structure positioned within the internal component chamber. The spider structure has (i) a spider hub and (ii) a spider shaft which extends from the spider hub. The differential assembly further includes a pinion gear positioned within the internal component chamber and around the spider shaft. The differential assembly also includes a bearing assembly positioned within the internal component chamber. The bearing assembly is interposed between the pinion gear and the spider shaft, wherein (i) the spider structure has a fluid spider channel having a fluid spider inlet and a fluid spider outlet, (ii) the fluid housing inlet is in fluid communication with the fluid spider inlet, and (iii) the fluid spider outlet is in fluid communication with the fluid housing outlet.