Abstract: Various aspects of the subject technology relate to systems, methods, and machine-readable media for outputting overlapping graphical objects via a graphical user interface. Various aspects can include determining a plurality of shapes as a subset of a set of shapes associated with the graphical objects. Aspects can also include determining intersections of the plurality of shapes based on a maximum shape dimension (e.g., height) and based on assigned weights to each of the set of shapes. Aspects can include determining a visibility parameter of each shape of the plurality of shapes based on whether each shape intersects with one or more other shapes. Aspects can include providing instructions to display the graphical user interface at a viewport parameter according to the visibility parameter and instructions to output labels of the graphical objects bounded by the set of shapes based on the viewport parameter.

Abstract: Various aspects of the subject technology relate to systems, methods, and machine-readable media for outputting overlapping graphical objects via a graphical user interface. Various aspects can include determining a plurality of shapes as a subset of a set of shapes associated with the graphical objects. Aspects can also include determining intersections of the plurality of shapes based on a maximum shape dimension (e.g., height) and based on assigned weights to each of the set of shapes. Aspects can include determining a visibility parameter of each shape of the plurality of shapes based on whether each shape intersects with one or more other shapes. Aspects can include providing instructions to display the graphical user interface at a viewport parameter according to the visibility parameter and instructions to output labels of the graphical objects bounded by the set of shapes based on the viewport parameter.

Abstract: Methods, systems, and storage media for generating a polygon representation of a plurality of data points are disclosed. Exemplary implementations can: receive a representation of data points from a data source, the representation comprising at least a two-dimensional (2D) data plot; calculate a core representation of the data points; dilate the core representation of the data points, comprising multiplying each data point by a multiple of an epsilon distance; generate dilated points based on the multiplying of each data point; generate a polygon representation of the data points based at least in part on intersections between the dilated points; and cause display of the polygon representation through a user interface.

Abstract: Embodiments of the present disclosure provide screening methods for identifying target molecules capable of being post-translationally modified.

Abstract: The invention provides methods of analyzing a sample. In general, the methods involve multi-dimensionally fractionating a sample to produce a set of sub-fractions, identifying a sub-fraction of interest by evaluating binding of a first portion of the sub-fractions to a binding agent; and analyzing the mass of analytes in a second portion of the sub-fraction of interest. Also provided is a system for performing the subject methods. The invention finds use in a variety of different medical, research and proteomics applications.

Abstract: The invention provides methods for preparing a sample for matrix-assisted laser desorption ionization (MALDI). In general, the methods involve: binding analytes in a sample to capture agents that are bound to matrix that is present in a plurality of wells of a multi-well sample plate, washing any unbound analytes from the matrix, cleaving any bound analyte/capture agent complexes with a MALDI cleavage agent, and depositing the cleavage products on a multi-sample MALDI sample plate. Kits and other compositions are provided for performing the subject methods. The subject invention finds use in methods of simultaneously assessing the presence of several analytes in a single sample, and, as such, the invention finds use in a variety of different medical, research and proteomics applications.

Abstract: The invention provides methods for preparing a MALDI sample plate. In general, the methods involve contacting a sample with an array of features containing capture agents that specifically bind to analytes, processing any analytes bound to the capture agents for MALDI analysis, and transferring the processed analytes to a MALDI sample plate. Also provided is a system for preparing a MALDI sample plate, containing an automatic fluid delivery device that is fluidically connected to a sample, and also to MALDI processing agents. In certain embodiments, the analytes present on the prepared subject MALDI sample plate may be evaluated by mass spectrometry. Kits and other compositions are provided for performing the subject methods. The subject invention finds use in methods of simultaneously assessing the presence of several analytes in a single sample, and, as such, the invention finds use in a variety of different medical, research and proteomics applications.

Abstract: A multi-dimensional chemical-analysis system includes a longitudinally extending iso-electric focusing (IEF) channel and transversely extending high-pressure liquid chromatography (HPLC) channels. Piezo-electric pumps force sample fluid from the IEF channel to form jets as it exits through respective pump nozzles. The jets then enter the HPLC channels for parallel second-dimension separations. Alternatively, the jets can be used to “print” sample onto a moving medium to provide a two-dimensional time-vs.-band-position distribution of sample components.