Abstract: An off-highway recreational vehicle includes side-by-side passenger and driver seats held within a chassis. The seats sit low in the chassis and are covered by a roll-over protection system (ROPS). The vehicle is powered by an engine rearward of the seats that utilizes a continuously variable transmission (CVT) to provide power to the ground engaging members, wherein the CVT is cooled via air captured by a CVT intake body located adjacent the driver-side seat, between the frame and external panels of the utility vehicle.

Abstract: The present disclosure relates to catalytic static mixers comprising catalytic material. The static mixers can be configured for use with continuous flow chemical reactors, for example tubular continuous flow chemical reactors for heterogeneous catalysis reactions. This disclosure also relates to processes for preparing static mixers. This disclosure also relates to continuous flow chemical reactors comprising the static mixers, systems comprising the continuous flow chemical reactors, processes for synthesising products using the continuous flow reactors, and methods for screening catalytic materials using the static mixers.

Abstract: Provided herein are methods for treating metastatic prostate cancer using anti-androgen compounds and radionuclide-labeled androgens.

Abstract: A power tool, such as a cast saw is disclosed. The cast saw is equipped with at least one thermocouple and and/or at least one infrared detector that measure the temperature of the cutting blade on the cast saw or the area in the cast immediately surrounding the cutting blade. The cast saw is also equipped with at least one LED that can alert a user of the cast saw when blade or the area in the cast immediately surrounding the blade is approaching or has reached a temperature that may burn a patient. Also disclosed is a shroud for the cutting blade of the cast saw. The shroud not only surrounds at least part of the blade but also houses the thermocouple or infrared detector and the LEDs(s). A method of operating the cast saw to cut a cast off of a patient is also disclosed.

Abstract: Provided, inter alia, are methods and compositions for treating FTO-mediated cancer.

Abstract: Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.

Abstract: A warp knitted mesh fabric constructed of synthetic, or synthetic and natural, fibers is characterized by having a low density, open construction with a high profile for spacing a garment constructed from the fabric from the skin of a wearer of the garment.

Abstract: An off-highway recreational vehicle includes side-by-side passenger and driver seats held within a chassis. The seats sit low in the chassis and are covered by a roll-over protection system (ROPS). The vehicle is powered by an engine rearward of the seats that utilizes a continuously variable transmission (CVT) to provide power to the ground engaging members, wherein the CVT is cooled via air captured by a CVT intake body located adjacent the driver-side seat, between the frame and external panels of the utility vehicle.

Abstract: Kits and methods for use in intraoperative trailing of hip prostheses to determine an appropriate length for the femoral neck component of a prosthetic hip joint, are described. A kit for use in selecting a femoral neck component of an orthopaedic joint prosthesis kit comprises a first (10) and a second (110) broach. Each of the first and second broaches has a neck connection element comprising a projection (12, 112) extending from a proximal surface (14, 114) of the broach, each projection having a length (L). The projection on the first broach has a different length than the projection on the second broach. The kit also includes a trial femoral neck (30) component having a neck connection element in the form of a recess (36) in a distal surface (34).

Abstract: Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.

Abstract: Disclosed herein inter alia are compositions and methods for treating cancer using 5-Br-indirubin derivatives.

Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.

Abstract: Provided herein, inter alia, is the synthesis of ETP derivatives. The synthetic methods described herein include converting a ring bridging trisulfide compound of formula to a ring bridging disulfide compound of formula Also provided herein are compositions comprising thereof.

Abstract: Provided herein are, inter alia, compounds inhibiting poly(ADP-ribose) Glycohydrolase (PARG) in a cancer cell and methods of treating cancer using compounds of the invention.

Abstract: The invention provides a reamer handle comprising: a shank having a distal tool coupling end adapted to releasably couple to a part of a surgical tool and a proximal end; a retractable catch which is linearly displaceable along the shank between a non-retracted position in which the catch captures the surgical tool within the distal tool coupling end of the tool holder and a retracted position in which the catch enables the tool to be released from the distal tool coupling end; a biasing member configured to bias the catch in the non-retracted position; and a sleeve extending along the shank. The sleeve comprises: a distally located catch contacting portion and a proximally located handle portion for manually displacing the sleeve relative to the shank such that displacement of the catch contacting portion moves the retractable catch between the non-retracted position and the retracted position to enable capture and release of the tool from the tool holder.

Abstract: Disclosed herein inter alia are compositions and methods for treating cancer using thioindirubin derivatives.

Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.

Abstract: Provided herein are, inter alia, methods of treating cancer using compounds of the invention.

Abstract: A surgical rotational cutting tool, a surgical kit and a method of preparing a femur to receive a stem of a femoral prosthetic. The tool includes a longitudinal axis and a shaft extending along the longitudinal axis, which has a proximal end and a distal end. The tool also includes a head located at the distal end of the shaft. The head includes a pointed distal tip, a bone contacting outer surface having a portion which curves inwards toward the longitudinal axis as it approaches the tip, and a plurality of flutes. The edges of distal parts of neighboring pairs of the flutes meet to define a plurality of cutting edges which extend proximally from the pointed distal tip. A proximal part of each flute extends proximally across the curved portion.

Abstract: Disclosed herein, inter alia, are pyridopyrazines and methods of using the same.