Abstract: Provided herein are compositions and methods for reducing expression of C9orf72 transcripts in cells containing expanded intronic GGGGCC regions, including those in subjects having or at risk of developing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

Abstract: The present disclosure relates to recombinant RNA molecules encoding an oncolytic virus genome. The present disclosure further relates to the encapsulation of the recombinant RNA molecules and the use of the recombinant RNA molecules and/or particles for the treatment and prevention of cancer.

Abstract: Systems disclosed herein are directed to a display stand unit for a retail environment. The display stand unit includes a base having an interior and a display stand. The display stand includes a stem that connects to and extends upwardly from the base and a receiving surface that is suspended above and spaced away from the base by the stem. The receiving surface is configured to releasably hold an electronic device above and spaced away from the base. The display stand unit further includes a security cable that extends out from the base. The security cable is configured to attach to the electronic device to movably secure the electronic device to the base. The display stand unit further includes a retractor disposed within the interior of the base and connected to the security cable. The retractor automatically retracts the security cable.

Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

Abstract: Systems and methods for providing a separate interest rate for an individual transaction are disclosed. A system may provide a service associated with a account having an account balance and an associated first interest rate. The system may include a service device having one or more memory devices storing instructions and one or more processors configured to execute the instructions to perform a separate interest rate service process. The process may include providing a separate interest rate service offer to a client device and receiving a separate interest rate selection from the client device. The process may also include determining a selected portion of the account balance corresponding to an amount to which a second interest rate, different from the first interest rate, is to be applied based on the separate interest rate selection.

Abstract: A method of assisting a user with the discovery of program features is provided. The method includes detecting a selection of a data structure within a user interface, determining a contextual parameter based on the selected data structure, the contextual parameter associated with a modifiable feature of the selected data structure, determining options for generating program code configured to modify the modifiable feature are available based on the contextual parameter and a predefined inferential relationship between the contextual parameter and the modifiable feature of the selected data structure, and prompting the user in the user interface with information indicating that the determined options for generating the program code are accessible in the user interface.

Abstract: The disclosure generally pertains to systems and methods for predicting energy consumption in vehicles. In an example method, a predicted energy consumption model associated with a vehicle may be determined. Sensor data associated with the vehicle may be received via a plurality of sensors associated with the vehicle. A driver-based energy consumption model associated with the vehicle may then be determined based at least in part on the sensor data. An estimated energy consumption model associated with the vehicle may then be determined based at least in part on the predicted energy consumption model and the driver-based energy consumption model. A vehicle charging prediction model may then be determined based at least in part on the estimated energy consumption model.

Abstract: A technique for providing search results may include determining a first entity type, a second entity type, and a relationship type based on a compositional query. The technique may also include identifying nodes of a knowledge graph corresponding to entity references of the first entity type and entity references of the second entity type. The technique may also include determining from the knowledge graph an attribute value corresponding to the relationship type for each entity reference of the first entity type and for each entity reference of the second entity type. The technique may also include comparing the attribute value of each entity reference of the first entity type with the attribute value of each entity reference of the second entity type. The technique may also include determining one or more resultant entity references from the entity references of the first entity type based on the comparing.

Abstract: Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.

Abstract: The disclosed devices may include a driver circuit including a voltage boost circuit, a pulse modulation controller, and optionally a headroom processor. The voltage boost circuit may be configured to receive a device input voltage (such as a battery voltage) and generate a backlight drive voltage. The pulse modulation controller may be configured to provide a pulse modulation signal to the voltage boost circuit, and may include a digital circuit or an analog circuit. Example devices may include a backlight unit receiving the backlight voltage. The optional headroom processor may provide a headroom signal to the pulse modulation controller based on a headroom voltage determined from the backlight unit. Devices may further include a backlight unit including an arrangement of light-emissive elements, and may include display devices such as head-mounted devices. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A computer-implemented system and method for automated traffic flow control using domain name for one or more devices enabled for connectivity over cellular network are disclosed. The computer-implemented method for automated traffic flow control using domain name for one or more devices enabled for connectivity includes receiving device information for the one or more devices; receiving domain name information for at least one domain name that the one or more devices are allowed to access, denied to access or a combination thereof; associating the at least one domain name with one or more internet protocol (IP) addresses; monitoring the at least one domain for change in the one or more IP addresses for that domain; and updating the one or more IP addresses of the domain name if any change in the one or more IP addresses for that domain is found.

Abstract: A computer-implemented method, system, and a computer program product for delivering a shoulder-tap to one or more battery-constrained devices are disclosed. The computer-implemented method includes receiving a shoulder-tap request; storing the shoulder-tap request in a database; retrieving last known network session information for the one or more battery-constrained devices; calculating shoulder-tap beacon frequency for each of the one or more battery-constrained devices; creating a shoulder-tap beacon for each of the one or more battery-constrained devices; and sending the shoulder-tap beacon to the destination IP address for each of the one or more battery-constrained devices in the calculated shoulder-tap beacon frequency.

Abstract: A brush-like device that adapts to tangles in hair and allows for easy removal of hair post-groom using uniquely shaped, anisotropic papillae not unlike those found on a feline tongue.

Abstract: A computer-implemented method, system, and computer program product for defining and enforcing network traffic policy for one or more devices enabled for connectivity over a communications network are disclosed. The method for defining and enforcing network traffic policy for one or more devices enabled for connectivity includes defining traffic policy rules for a service profile, wherein the service profile is service behavior definition based on communications network subscription; assigning a range of network assigned unique identifiers to the service profile; associating at least one device with at least one of the range of network assigned unique identifiers assigned to the service profile using communication network subscription identifier; and enforcing the defined traffic policy rules on the network traffic to and from the at least one device based on the network assigned unique identifier associated to the said at least one device.

Abstract: A computer-implemented method and system are disclosed for connecting one or more devices to subscriptions and cellular or other wireless billing plans. The method includes enrolling the one or more devices enabled for connectivity to cellular or other wireless service in a cellular or other wireless subscription and associated billing plan, wherein the enrollment includes providing an identifier for the one or more devices to a cellular or other wireless service provider chosen by a second user, and allowing the second user to use capabilities of the one or more devices governed by the cellular or other wireless subscription and an associated billing plan chosen by the second user; while the one or more devices are also configured to allow a first user to use capabilities of the one or more devices as governed by the cellular or other wireless subscription and an associated billing plan of the first user's choice.

Abstract: Methods, systems, and devices that takes advantage of the unique fluid dynamics involved when oscillating flow across a sensor or sensor array. A time-variant source of information about an agent(s) of interest being sensored is established. This source of information is used in machine learning algorithms to speed up the time and accuracy of agent classification and identification.

Abstract: A computer-implemented method, system, and a computer program product for delivering a shoulder-tap to one or more battery-constrained devices are disclosed. The computer-implemented method includes receiving a shoulder-tap request; storing the shoulder-tap request in a database; retrieving last known network session information for the one or more battery-constrained devices; calculating shoulder-tap beacon frequency for each of the one or more battery-constrained devices; creating a shoulder-tap beacon for each of the one or more battery-constrained devices; and sending the shoulder-tap beacon to the destination IP address for each of the one or more battery-constrained devices in the calculated shoulder-tap beacon frequency.

Abstract: A computer-implemented method and system are disclosed for connecting a device to subscriptions and cellular billing plans. The method includes enrolling a second device enabled for connectivity to cellular or other wireless service in a cellular subscription and associated billing plan associated with a first device, wherein the enrollment includes providing an identifier for the second device to a cellular service provider associated with the first device by a second user, and allowing a second user to use capabilities of the second device as governed by the cellular subscription and an associated billing plan associated with the first device; while the second device is also configured to allow a first user to use capabilities of the second device as governed by the cellular subscription and an associated billing plan of the first user's choice.

Abstract: A computer-implemented system and method for automated traffic flow control using domain name for one or more devices enabled for connectivity over cellular network are disclosed. The computer-implemented method for automated traffic flow control using domain name for one or more devices enabled for connectivity includes receiving device information for the one or more devices; receiving domain name information for at least one domain name that the one or more devices are allowed to access, denied to access or a combination thereof; associating the at least one domain name with one or more internet protocol (IP) addresses; monitoring the at least one domain for change in the one or more IP addresses for that domain; and updating the one or more IP addresses of the domain name if any change in the one or more IP addresses for that domain is found.

Abstract: A computer-implemented system and method for automated traffic flow control using domain name for one or more devices enabled for connectivity over cellular network are disclosed. The computer-implemented method for automated traffic flow control using domain name for one or more devices enabled for connectivity includes receiving device information for the one or more devices; receiving domain name information for at least one domain name that the one or more devices are allowed to access; associating the at least one domain name with one or more internet protocol (IP) addresses; monitoring the at least one domain for change in the one or more IP addresses for that domain; and updating the one or more IP addresses of the domain name if any change in the one or more IP addresses for that domain is found.