Abstract: The present invention relates to echinocandin cyclopeptides and to methods for preparing echinocandin cyclopeptides.

Abstract: Disclosed herein are compositions, methods, and transgenic animals for sex biasing offspring of male animals, as well as methods of screening for sex biasing agents.

Abstract: Systems, programs, non-transitory computer readable mediums, and methods of managing multiple and concurrent online advertising campaigns to eliminate user fatigue are disclosed. In particular, a campaign management server generates multiple target lists of users from a data warehouse for a plurality of pre-defined online advertising campaigns. The users on the target lists are selected to receive electronic communications, such as email or text, containing advertisements based upon target profiles associated with the campaigns as determined by marketing objectives. The advertising campaigns are prioritized such that users on a target list of a higher prioritized campaign are suppressed from lower prioritized campaigns in order to insure that the users receive a predetermined number of electronic communications within a set time frame.

Abstract: Variable geometry turbines having new configurations of vanes are disclosed. New methods for designating new configurations of vanes for geometry turbines having are also disclosed.

Abstract: The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.

Abstract: Disclosed here are airframe component assemblies including example embodiments with a root connected to an aircraft fuselage, a free section with a connection portion with holes, a slidable attachment section formed to fit between the root and the free section, and an elastomeric retention device coupled to the root and the slidable attachment section, the elastomeric retention device configured to exert a force to pull the slidable attachment toward the root.

Abstract: Devices are presented for measurement of an analyte concentration. The devices comprise: a sensor configured to generate a signal indicative of a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme domain comprising an enzyme, a base polymer, and a hydrophilic polymer which makes up from about 5 wt. % to about 30 wt. % of the enzyme domain.

Abstract: Variable geometry turbines having a turbine housing with an inlet and an outlet, a turbine wheel rotatably mounted between the inlet and the outlet, a movable wall member having an inlet passageway between the inlet of the turbine housing and the turbine wheel, and a plurality of vanes circumferentially spaced and extending across the inlet passageway, the plurality of vanes having a specified shape. Methods for designing configurations of vanes for variable geometry turbines.

Abstract: Variable geometry turbines having new configurations of vanes are disclosed. New methods for designing new configurations of vanes for geometry turbines having are also disclosed.

Abstract: There is provided an assembly for a turbocharger, the assembly comprising a turbine housing and a nozzle ring, wherein one of the turbine housing and the nozzle ring comprises a tongue and the other of the turbine housing and the nozzle ring comprises a corresponding slot, the tongue and slot being configured to engage and prevent relative rotation of the turbine housing and the nozzle ring. Also provided is a method of manufacturing a turbine housing, assembly for use in a turbocharger, or a turbocharger.

Abstract: A method of managing power in a power microgrid, the method comprising: generating, by the facility controller, time-dependent predicted power demand data representative of at least a predicted power demand of the industrial gas production facility for a predetermined time period; utilizing, by the power controller, the predicted power demand data to generate control set point values for controlling a generated power output of the one or more renewable power sources and for controlling a flow of electrical power to or from the energy storage resources, the control set point values being selected to adjust the available power as a function of time for the predetermined time period to correspond to the demanded power for the predetermined time period; and sending one or more control signals comprising the control set point values to the one or more renewable power sources and to the one or more energy storage resources.

Abstract: A uterine manipulator device includes: an elongated cannulated tube comprising a proximal end and a distal end; a cervical cup having a top proximal portion of a first diameter and a base distal portion of a second smaller diameter, wherein: the base distal portion includes a hole formed therein having a perimeter including a distal end and a proximal end, and including a longitudinal axis positioned therethrough; one of the proximal end of the perimeter and the distal end of the perimeter is angled away from the longitudinal axis and the other of the proximal end of the perimeter and the distal end of the perimeter is in line with the longitudinal axis; and the elongated cannulated tube is positioned through the hole in the cervical cup.

Abstract: A method for producing an ultrasonic transducer or ultrasonic transducer array, the method comprising providing or depositing a layer of piezoelectric material on a substrate. The piezoelectric material is a doped, co-deposited or alloyed piezoelectric material. The piezoelectric material comprises: a doped, co-deposited or alloyed metal oxide or metal nitride, the metal oxide or metal nitride being doped, co-deposited or alloyed with vanadium or a compound thereof; or zinc oxide doped, co-deposited or alloyed with a transition metal or a compound thereof. Optionally, the deposition of the layer of piezoelectric material is by sputter coating, e.g. using a sputtering target that comprises a doped or alloyed piezoelectric material. In examples, the layer of piezoelectric material is deposited onto the substrate using high power impulse magnetron sputtering (HIPIMS). Further enhancement may be obtained using substrate biasing (e.g. DC and/or RF) during deposition of the layer of piezoelectric material.

Abstract: An ultrasonic sensor comprising an ultrasonic transducer, the ultrasonic transducer comprising: a piezoelectric element; and an active electrode and a counter electrode adapted for electrical connection to the piezoelectric element; wherein the piezoelectric element, the active electrode and the counter electrode are comprised in at least part of an electrical circuit for operating the piezoelectric element; the ultrasonic sensor is mounted or configured to be mountable to an entity to be sensed; and the ultrasonic sensor is adapted such that removal of the ultrasonic sensor from the entity causes a breaking of an electrical circuit so as to render the ultrasonic sensor inoperable or irreversibly inoperable.

Abstract: The disclosure features non-irritating pharmaceutical compositions containing CD101 in pharmaceutical acceptable salt (e.g., CD101 acetate) or neutral form. The pharmaceutical compositions can be intravenously administered to a subject to treat fungal infections (e.g., candidiasis) in the subject.

Abstract: The present invention relates to echinocandin cyclopeptides and to methods for preparing echinocandin cyclopeptides.

Abstract: There is provided an assembly for a turbocharger, the assembly comprising a turbine housing and a nozzle ring, wherein one of the turbine housing and the nozzle ring comprises a tongue and the other of the turbine housing and the nozzle ring comprises a corresponding slot, the tongue and slot being configured to engage and prevent relative rotation of the turbine housing and the nozzle ring. Also provided is a method of manufacturing a turbine housing, assembly for use in a turbocharger, or a turbocharger.

Abstract: Three dimensional (3D) graph structures are constructed from images captured from subjects. The 3D graph structures are composed of nodes which can be queried to identify presence of anatomical abnormalities, such as multiple sclerosis lesions. As additional images are captured from the subjects over time, 3D graph structures are efficiently updated and analyzed, which reveals the topology and temporal nature of multiple sclerosis disease by exposing novel structural features of the brain through representation of data as interactive 3D projections.