Patents by Inventor DAVID HUSO

DAVID HUSO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF INHIBITING CANCER STEM CELLS WITH HMGA1 INHIBITORS
    Publication number: 20200009177
    Abstract: The presently disclosed subject matter relates to methods of inhibiting cancer stem cells and growth of aggressive and/or poorly differentiated metastatic tumors comprising the cancer stem cells with HMGA1 inhibitors. The presently disclosed subject matter also provides methods of selecting and treating a subject with aggressive and/or poorly differentiated metastatic cancer using HMGA1 inhibitors.
    Type: Application
    Filed: February 4, 2019
    Publication date: January 9, 2020
    Inventors: Linda M. Smith Resar, David Huso, Leslie Cope
  • ENHANCED ORGANOID FORMATION AND INTESTINAL STEM CELL RENEWAL
    Publication number: 20190076482
    Abstract: High mobility group A1 (Hmga1) chromatin remodeling proteins are enriched in intestinal stem cells (ISCs), although their function in this setting was unknown. The present invention describes a method of producing a genetically modified organoid comprising the following steps: isolating a crypt of the small intestine; culturing a portion of the crypt in a culture medium; forming an organoid; and transducing the organoid with a vector comprising Hmga1. Methods using genetically modified organoids to treat or prevent injuries including cancer are described.
    Type: Application
    Filed: March 13, 2017
    Publication date: March 14, 2019
    Inventors: Linda Smith-Resar, David Huso, Lingling Xian
  • Methods of inhibiting cancer stem cells with HMGA1 inhibitors
    Patent number: 10213454
    Abstract: The presently disclosed subject matter relates to methods of inhibiting cancer stem cells and growth of aggressive and/or poorly differentiated metastatic tumors comprising the cancer stem cells with HMGA1 inhibitors. The presently disclosed subject matter also provides methods of selecting and treating a subject with aggressive and/or poorly differentiated metastatic cancer using HMGA1 inhibitors.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: February 26, 2019
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Linda M. Smith Resar, David Huso, Leslie Cope
  • METHODS OF INHIBITING CANCER STEM CELLS WITH HMGA1 INHIBITORS
    Publication number: 20170202867
    Abstract: The presently disclosed subject matter relates to methods of inhibiting cancer stem cells and growth of aggressive and/or poorly differentiated metastatic tumors comprising the cancer stem cells with HMGA1 inhibitors. The presently disclosed subject matter also provides methods of selecting and treating a subject with aggressive and/or poorly differentiated metastatic cancer using HMGA1 inhibitors.
    Type: Application
    Filed: January 5, 2017
    Publication date: July 20, 2017
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: LINDA M. SMITH RESAR, DAVID HUSO, LESLIE COPE
  • Methods of inhibiting cancer stem cells with HMGA1 inhibitors
    Patent number: 9545417
    Abstract: The presently disclosed subject matter relates to methods of inhibiting cancer stem cells and growth of aggressive and/or poorly differentiated metastatic tumors comprising the cancer stem cells with HMGA1 inhibitors. The presently disclosed subject matter also provides methods of selecting and treating a subject with aggressive and/or poorly differentiated metastatic cancer using HMGA1 inhibitors.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: January 17, 2017
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Linda M. Smith Resar, David Huso, Leslie Cope
  • METHODS OF INHIBITING CANCER STEM CELLS WITH HMGA1 INHIBITORS
    Publication number: 20150315589
    Abstract: The presently disclosed subject matter relates to methods of inhibiting cancer stem cells and growth of aggressive and/or poorly differentiated metastatic tumors comprising the cancer stem cells with HMGA1 inhibitors. The presently disclosed subject matter also provides methods of selecting and treating a subject with aggressive and/or poorly differentiated metastatic cancer using HMGA1 inhibitors.
    Type: Application
    Filed: May 1, 2015
    Publication date: November 5, 2015
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: LINDA M. SMITH RESAR, DAVID HUSO, LESLIE COPE