Patents by Inventor David I. Smith

David I. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chicken interleukin-15 and uses thereof
    Publication number: 20020150554
    Abstract: The present invention pertains to isolated DNA encoding avian interleukin-15 and to purified interleukin-15 polypeptides.
    Type: Application
    Filed: July 17, 2001
    Publication date: October 17, 2002
    Applicant: Wayne State University
    Inventors: Roy S. Sundick, Lily A. Jones, David I. Smith
  • Polynucleotide probe and kit for amplifying signal detection in hybridization assays
    Patent number: 6306657
    Abstract: The present invention provides a method for simplifying and significantly enhancing the sensitivity of nucleic acid hybridization assays. A method is described whereby a single-stranded primary nucleic acid sequence that includes a region of sequences complementary to a single-stranded target nucleic acid sequence is hybridized to the target molecule. Stability of the double-stranded complex thereby formed can be enhanced by using RNA as the probe if DNA is the target or DNA as the probe if RNA is the target. The probe-target complex is subsequently immunocaptured for detection. After washing away extraneous material, a secondary nucleic acid sequence containing many repeating sequence units is hybridized to the probe component of the immobilized probe-target complex. Detection occurs following hybridization of many labelled nucleic acid sequence probes to each of the repeating sequence units of a nucleic acid amplification probe.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: October 23, 2001
    Assignee: Kalyx Biosciences, Inc.
    Inventors: Sithian Pandian, Eng Jom Aw, David I. Smith
  • Chicken interleukin-15 and uses thereof
    Patent number: 6287554
    Abstract: The present invention pertains to isolated DNA encoding avian interleukin-15 and to purified interleukin-15 polypeptides.
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: September 11, 2001
    Assignee: Wayne State University
    Inventors: Roy S. Sundick, Lily A. Jones, David I. Smith
  • Chicken interleukin-15 and uses thereof
    Patent number: 6190901
    Abstract: The present invention pertains to isolated DNA encoding avian interleukin-15 and to purified interleukin-15 polypeptides.
    Type: Grant
    Filed: October 10, 1996
    Date of Patent: February 20, 2001
    Assignee: Wayne State University
    Inventors: Roy S. Sundick, Lily A. Jones, David I. Smith
  • Device and method of use for detection of bacterial lipopolysaccharides
    Patent number: 5888754
    Abstract: This invention relates to a device comprising a hydrophobic solid support coated with a chemical that can capture bacterial lipopolysaccharides (LPS). This invention also relates to the use of such a device in an immunoassay for the detection of microorganisms. This invention also relates to the incorporation of such a device into a diagnostic kit.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: March 30, 1999
    Assignee: Kalyx Biosciences Inc.
    Inventors: Sithian Pandian, Eng Jom Aw, David I. Smith
  • Method of amplification for increasing the sensitivity of detecting nucleic acid-probe target hybrids
    Patent number: 5627030
    Abstract: The present invention provides a method for simplifying and significantly enhancing the sensitivity of nucleic acid hybridization assays. A method is described whereby a single-stranded primary nucleic acid sequence that includes a region of sequences complementary to a single-stranded target nucleic acid sequence is hybridized to the target molecule. Stability of the double-stranded complex thereby formed can be enhanced by using RNA as the probe if DNA is the target or DNA as the probe if RNA is the target. The probe-target complex is subsequently immunocaptured for detection. After washing away extraneous material, a secondary nucleic acid sequence containing many repeating sequence units is hybridized to the probe component of the immobilized probe-target complex. Detection occurs following hybridization of many labelled nucleic acid sequence probes to each of the repeating sequence units of a nucleic acid amplification probe.
    Type: Grant
    Filed: July 15, 1994
    Date of Patent: May 6, 1997
    Assignee: Kalyx Biosciences Inc.
    Inventors: Sithian Pandian, Eng J. Aw, David I. Smith
  • Lithographic printing plates containing functional groups capable of reacting with a silane compound
    Patent number: 5550001
    Abstract: A radiation-sensitive plate comprises a substrate coated with a radiation-sensitive composition including a component having groups imparting solubility in aqueous solutions and a component having functional groups capable of reacting with a silane compound. The surface of the composition is modified by reaction with a silane compound. The plate gives rise to images of improved ink receptivity and can be developed in aqueous developer liquids after image-wise exposure.
    Type: Grant
    Filed: May 5, 1994
    Date of Patent: August 27, 1996
    Assignee: DuPont (U.K.) Limited
    Inventors: John R. Wade, Michael J. Pratt, Robert A. W. Johnstone, David I. Smith
  • Levo-ciprofibrate
    Patent number: 5011985
    Abstract: Levo-ciprofibrate or a pharmaceutically acceptable salt thereof is disclosed.
    Type: Grant
    Filed: May 11, 1990
    Date of Patent: April 30, 1991
    Assignee: Sterling Drug Inc.
    Inventors: Eugene H. Cordes, George J. Ellames, John M. Herbert, David I. Smith
  • Dextro-ciprofibrate
    Patent number: 5011986
    Abstract: Dextro-ciprofibrate or a pharmaceutically acceptable salt thereof is disclosed.
    Type: Grant
    Filed: May 11, 1990
    Date of Patent: April 30, 1991
    Assignee: Sterling Drug Inc.
    Inventors: Eugene H. Cordes, George J. Ellames, John M. Herbert, David I. Smith